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Endoplasmic Reticulum Stress and Inflammation [PDF]
Digestive Diseases, 2012 Endoplasmic reticulum (ER) stress due to the presence of misfolded or unfolded proteins in the ER invokes a fundamental biological response, termed the unfolded protein response (UPR). The UPR is orchestrated by three main proximal effectors, of which the IRE1/XBP1 pathway represents the evolutionarily most conserved one.
Adolph TE +3 more
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KRE5 Suppression Induces Cell Wall Stress and Alternative ER Stress Response Required for Maintaining Cell Wall Integrity in Candida glabrata. [PDF]
PLoS ONE, 2016 The maintenance of cell wall integrity in fungi is required for normal cell growth, division, hyphae formation, and antifungal tolerance. We observed that endoplasmic reticulum stress regulated cell wall integrity in Candida glabrata, which possesses ...
Yutaka Tanaka +7 more
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An endoplasmic reticulum-specific cyclophilin. [PDF]
Molecular and Cellular Biology, 1991 Cyclophilin is a ubiquitously expressed cytosolic peptidyl-prolyl cis-trans isomerase that is inhibited by the immunosuppressive drug cyclosporin A. A degenerate oligonucleotide based on a conserved cyclophilin sequence was used to isolate cDNA clones representing a ubiquitously expressed mRNA from mice and humans.
Karl W. Hasel +3 more
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Frontiers in Physiology, 2014 Endoplasmic reticulum resident proteins, along with all proteins traveling through the secretory pathway must enter endoplasmic reticulum lumen through membrane-embedded translocons.
Michael eVincent +4 more
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STING an Endoplasmic Reticulum Adaptor that Facilitates Innate Immune Signaling
Nature, 2008 The cellular innate immune system is essential for recognizing pathogen infection and for establishing effective host defence. But critical molecular determinants responsible for facilitating an appropriate immune response—following infection with DNA ...
Hiroki Ishikawa, G. Barber
semanticscholar +1 more source
Endoplasmic reticulum: A metabolic compartment [PDF]
FEBS Letters, 2006 Several biochemical reactions and processes of cell biology are compartmentalized in the endoplasmic reticulum (ER). The view that the ER membrane is basically a scaffold for ER proteins, which is permeable to small molecules, is inconsistent with recent findings.
Csala, Miklós +2 more
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Frontiers in Immunology, 2019 Apoptosis is a form of cell death by which the body maintains the homeostasis of the internal environment. Apoptosis is an initiative cell death process that is controlled by genes and is mainly divided into endogenous pathways (mitochondrial pathway ...
Hai Hu, M. Tian, C. Ding, Shengqing Yu
semanticscholar +1 more source
Phosphatidylinositol synthesis at the endoplasmic reticulum. [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019 Phosphatidylinositol (PI) is a minor phospholipid with a characteristic fatty acid profile; it is highly enriched in stearic acid at the sn-1 position and arachidonic acid at the sn-2 position. PI is phosphorylated into seven specific derivatives, and individual species are involved in a vast array of cellular functions including signalling, membrane ...
Nicholas J. Blunsom, S. Cockcroft
semanticscholar +5 more sources
Biology Open, 2012 Summary Some nuclear envelope proteins are localised to both the nuclear envelope and the endoplasmic reticulum; therefore, it seems plausible that even small amounts of these proteins can influence the organisation of the endoplasmic reticulum. A simple
Ekaterina G. Volkova +2 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Thyroid hormone is essential for hippocampal redox environment and neuronal viability in adulthood, where its deficiency causes hypothyroidism related to oxidative and endoplasmic reticulum stresses in the hippocampus, resulting in neuronal death.
Vanessa Blas-Valdivia +5 more
doaj +1 more source