Results 31 to 40 of about 194,866 (319)
Neural Regeneration Research, 2015 Cerebral ischemia triggers secondary ischemia/reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear.
Jian-wen Yang, Zhi-ping Hu
doaj +1 more source
Stress-induced neuroprotective effects of epiregulin and amphiregulin. [PDF]
PLoS ONE, 2015 Members of the epidermal growth factor family play important roles in the regulation of cell growth, proliferation, and survival. However, the specific roles of each epidermal growth factor family member with respect to brain injury are not well ...
Libin Zhan +4 more
doaj +1 more source
Protein Folding in the Endoplasmic Reticulum [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 In this article, we will cover the folding of proteins in the lumen of the endoplasmic reticulum (ER), including the role of three types of covalent modifications: signal peptide removal, N-linked glycosylation, and disulfide bond formation, as well as the function and importance of resident ER folding factors.
Daniel N. Hebert, Ineke Braakman
openaire +4 more sources
Membrane-associated RING ubiquitin ligase RNF-121 and advancement of cancer [PDF]
Cellular, Molecular and Biomedical ReportsExploration of E3 ubiquitin ligases as potential therapeutic targets has been ongoing for two to three decades. Various chemicals and drugs have been developed to either upregulate or inhibit the activity of E3 ligases, aiming to mitigate several ...
Somesh Roy
doaj +1 more source
A quantitative model for refilling of the sarcoplasmic reticulum during vascular smooth muscle asynchronous [Ca2+] oscillations [PDF]
Cell Calcium 42, 565-75 (2007), 2006 We have developed a quantitative model for the creation of cytoplasmic Ca2+ gradients near the inner surface of the plasma membrane (PM). In particular we simulated the refilling of the sarcoplasmic reticulum (SR) via PM-SR junctions during asynchronous [Ca2+] oscillations in smooth muscle cells of the rabbit inferior vena cava.
arxiv +1 more source
PLoS ONE, 2022 Mutation-induced protein misfolding of pancreatic secretory enzymes and consequent endoplasmic reticulum stress can cause chronic pancreatitis. A recent study revealed that cigarette smoke also increases the risk of the disease through endoplasmic ...
Norbert Kassay +3 more
doaj +2 more sources
Nature Communications, 2019 Immunogenic cell death (ICD)-associated immunogenicity can be evoked through reactive oxygen species (ROS) produced via endoplasmic reticulum (ER) stress.
Wei Li +14 more
semanticscholar +1 more source
Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases
Neural Regeneration ResearchThe endoplasmic reticulum, a key cellular organelle, regulates a wide variety of cellular activities. Endoplasmic reticulum autophagy, one of the quality control systems of the endoplasmic reticulum, plays a pivotal role in maintaining endoplasmic ...
Xiu-Yun Zhao +5 more
doaj +1 more source
Protein accumulation in the endoplasmic reticulum as a non-equilibrium phase transition [PDF]
, 2014 Several neurological disorders are associated with the aggregation of aberrant proteins, often localized in intracellular organelles such as the endoplasmic reticulum. Here we study protein aggregation kinetics by mean-field reactions and three dimensional Monte carlo simulations of diffusion-limited aggregation of linear polymers in a confined space ...
arxiv +1 more source
Tube geometry controls protein cluster conformation and stability on the endoplasmic reticulum surface [PDF]
arXiv, 2023 The endoplasmic reticulum (ER), a cellular organelle that forms a cell-spanning network of tubes and sheets, is an important location of protein synthesis and folding. When the ER experiences sustained unfolded protein stress, IRE1 proteins embedded in the ER membrane activate and assemble into clusters as part of the unfolded protein response (UPR ...
arxiv