Results 231 to 240 of about 47,261 (313)
Advanced Science, Volume 13, Issue 11, 23 February 2026.A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley +1 more source
Targeted Delivery of Endosomal Escape Peptides to Enhance Immunotoxin Potency and Anti-cancer Efficacy. [PDF]
AAPS J, 2022 Polli JR +3 more
europepmc +1 more source
Therapeutic and diagnostic applications of extracellular vesicles [PDF]
, 2016 De Smedt, Stefaan +2 more
core +1 more source
Advanced Science, Volume 13, Issue 10, 18 February 2026.This study develops an mRNA therapy encoding a long‐acting GLP‐1/FGF21 fusion protein. A three‐tailed ionizable lipid engineered three‐component lipid nanoparticle delivers the mRNA to inguinal adipose tissue. In obese mice, this targeted, dual‐hormone treatment potently reduces body weight, fat mass, presenting a localized strategy for metabolic ...
Bin Ma +10 more
wiley +1 more source
Hastened Fusion-Dependent Endosomal Escape Improves Activity of Delivered Enzyme Cargo. [PDF]
ACS Cent SciVázquez-Maldonado AL +4 more
europepmc +1 more source
Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment
Advanced Science, Volume 13, Issue 10, 18 February 2026.This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang +7 more
wiley +1 more source
Advanced Science, Volume 13, Issue 9, 13 February 2026.Radiation induces polyploid giant cancer cells (PGCCs) that regenerate tumors through virus‐like budding. This process depends on a SNCG–FLOT2–CHMP4B signaling axis functioning in lipid raft microdomains. Disrupting these domains using statins or anti‐PCSK9 antibodies blocks PGCC budding, suppresses tumor repopulation, and enhances radiotherapy ...
Zheng Deng +20 more
wiley +1 more source
A new approach for direct visualization of unlabeled lipid nanoparticles for intracellular pathway analysis [PDF]
BIO Web of ConferencesTesta Filippo +9 more
doaj +1 more source
Biological Templates for Gold Nanocluster Assembly: Design and Biomedical Applications
Aggregate, Volume 7, Issue 2, February 2026.The review discusses the fundamental properties of ultrasmall gold nanoclusters and their surface modification strategies for targeted biomedical use. It examines biologically guided assembly processes and their effects on optical behavior, particularly aggregation‐induced emission.
Zeineb Ayed +3 more
wiley +1 more source