Results 61 to 70 of about 47,261 (313)

Endosomal Escape Pathways for Non-Viral Nucleic Acid Delivery Systems [PDF]

, 2012
Wanling Liang, Jenny K.W. Lam
openalex   +5 more sources

Lipid nanoparticle topology regulates endosomal escape and delivery of RNA to the cytoplasm

bioRxiv, 2022
RNA therapeutics have the potential to resolve a myriad of diseases caused by gene deficiency. Lipid nanoparticles (LNPs) are one of the most successful RNA delivery systems. However, expanding their application hinges on the discovery of next generation
Lining Zheng, Sarith R. Bandara, C. Leal
semanticscholar   +1 more source

Role of liposome and peptide in the synergistic enhancement of transfection with a lipopolyplex vector [PDF]

, 2015
Lipopolyplexes are of widespread interest for gene therapy due to their multifunctionality and high transfection efficiencies. Here we compared the biological and biophysical properties of a lipopolyplex formulation with its lipoplex and polyplex ...
A Elouahabi, A Rodger, AD Tagalakis, AD Tagalakis, AD Tagalakis, AD Tagalakis, AL Cozens, B Lamarre, B Norden, B Wang, CT de Ilarduya, D Edinger, E Collins, GY Wu, J Rejman, L Garcia, M Mannisto, M Whitmore, MJ Writer, MR Hicks, PL Felgner, QH Meng, QH Meng, R Marrington, RG Jenkins, S Ido, SA Irvine, SL Hart, SM Grosse, SW Hui, T Kurosaki, TR Dafforn   +31 more
core   +1 more source

Endosomal escape for cell-targeted proteins. Going out after going in.

Biotechnology Advances, 2023
Protein-based nanocarriers are versatile and biocompatible drug delivery systems. They are of particular interest in nanomedicine as they can recruit multiple functions in a single modular polypeptide.
Eric Voltà-Durán, Eloi Parladé, N. Serna, A. Villaverde, E. Vázquez, U. Unzueta   +5 more
semanticscholar   +1 more source

Synchronous conjugation of i-motif DNA and therapeutic siRNA on the vertexes of tetrahedral DNA nanocages for efficient gene silence

Acta Pharmaceutica Sinica B, 2021
The functionality of DNA biomacromolecules has been widely excavated, as therapeutic drugs, carriers, and functionalized modification derivatives.
Xiu Han, Xiang Xu, Ziheng Wu, Zhenghong Wu, Xiaole Qi   +4 more
doaj   +1 more source

Solid-phase-assisted synthesis of targeting peptide-PEG-oligo(ethane amino)amides for receptor-mediated gene delivery. [PDF]

, 2012
In the forthcoming era of cancer gene therapy, efforts will be devoted to the development of new efficient and non-toxic gene delivery vectors. In this regard, the use of Fmoc/Boc-protected oligo(ethane amino)acids as building blocks for solid-phase ...
Akinc, Aumailley, Behr, Blessing, Boussif, Breunig, Carlos Mas-Moruno, Chollet, Christian Dohmen, Christina Troiber, Cotten, Cox, David Schaffert, Davis, Davis, Dechantsreiter, Desgrosellier, Drake, Edinger, Ellman, Erbacher, Ernest Giralt, Ernst Wagner, Felding-Habermann, Felgner, Fella, Grandinetti, Harbottle, Hartmann, Hartmann, Haubner, Horst Kessler, Irene Martin, J., Kantlehner, Kichler, Kim, Kursa, Li, Lin, Luthman, Madder, Mas-Moruno, McKenzie, Meritxell Teixidó, Merkel, Meyer, Meyer, Michael Günther, Moghimi, Mosca, Nie, Oba, Oupicky, Pack, Petra Kos, Pfaff, Plank, Reis, Ruoslahti, Russ, Russ, Schaffert, Schaffert, Schaffert, Schiffelers, Sonawane, Trubetskoy, Ulrich Lächelt, Varkouhi, Wagner, Wagner, Wagner, Wagner, Walker, Wu, Xia, Xu, Zintchenko   +78 more
core   +3 more sources

Spatiotemporal Dynamics of Adenovirus Membrane Rupture and Endosomal Escape [PDF]

Journal of Virology, 2012
ABSTRACT A key step in adenovirus cell entry is viral penetration of cellular membranes to gain access to the cytoplasm and deliver the genome to the nucleus. Yet little is known about this important event in the adenoviral life cycle.
Oana, Maier, Shauna A, Marvin, Harald, Wodrich, Edward M, Campbell, Christopher M, Wiethoff   +4 more
openaire   +2 more sources

Exploring the HYDRAtion method for loading siRNA on liposomes : the interplay between stability and biological activity in human undiluted ascites fluid [PDF]

, 2016
Delivery of small interfering RNA (siRNA) is recently gaining tremendous attention for the treatment of ovarian cancer. The present study investigated the potential of different liposomal formulations composed of (2,3-dioleoyloxy-propyl)trimethylammonium
Braeckmans, Kevin, Ceelen, Wim, Dakwar, George, De Smedt, Stefaan, Remaut, Katrien   +4 more
core   +2 more sources

Visualization of the process of a nanocarrier-mediated gene delivery: stabilization, endocytosis and endosomal escape of genes for intracellular spreading

Journal of Nanobiotechnology, 2022
Nanoparticles have been widely applied as gene carrier for improving RNA interference (RNAi) efficiency in medical and agricultural fields. However, the mechanism and delivery process of nanoparticle-mediated RNAi is not directly visualized and ...
Zhongzheng Ma, Yangang Zheng, Zijian Chao, Hongtao Chen, Yunhui Zhang, Meizhen Yin, Jie Shen, Shuo Yan   +7 more
semanticscholar   +1 more source

Improving the Endosomal Escape of Cell-Penetrating Peptides and Their Cargos: Strategies and Challenges

Pharmaceuticals, 2012
Cell penetrating peptides (CPPs) can deliver cell-impermeable therapeutic cargos into cells. In particular, CPP-cargo conjugates tend to accumulate inside cells by endocytosis.
Jean-Philippe Pellois, Ting-Yi Wang, Ryan Baker, Nandhini Muthukrishnan, Alfredo Erazo-Oliveras   +4 more
doaj   +1 more source