Results 91 to 100 of about 187,332 (400)

Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation

Journal of Cell Biology, 1993
The clathrin-coated pit lattice is held onto the plasma membrane by an integral membrane protein that binds the clathrin AP-2 subunit with high affinity.
Li-Hsien Wang, K. Rothberg, R. Anderson
semanticscholar   +1 more source

Fluorescent Nanodiamonds Based Theranostic Platform for pH‐Sensitive Drug Delivery and Quantum Sensing

Advanced Functional Materials, EarlyView.
A multifunctional nanodiamond platform enables pH‐triggered Diazoxide (DZX) delivery and quantum sensing of subcellular radical dynamics in triple‐negative breast cancer cells. Diamond relaxometry revealed reduced lysosomal radicals during DZX‐induced mitochondrial radical elevation, providing insights into redox modulation and organelle‐ resolved ...
Kaiqui Wu, Siyu Fan, Yue Zhang, Willem Woudstra, Thomas Mulder, Laurens Boscher Navarro, Jur van Dijken, Katja Loos, Romana Schirhagl   +8 more
wiley   +1 more source

Lamp1 Increases the Efficiency of Lassa Virus Infection by Promoting Fusion in Less Acidic Endosomal Compartments

mBio, 2018
Lassa virus (LASV) is an arenavirus whose entry into host cells is mediated by a glycoprotein complex (GPC) comprised of a receptor binding subunit, GP1, a fusogenic transmembrane subunit, GP2, and a stable signal peptide.
Christine E. Hulseberg, Lucie Fénéant, Katarzyna M. Szymańska, Judith M. White   +3 more
doaj   +1 more source

Endosomal Cholesterol in Viral Infections – A Common Denominator?

Frontiers in Physiology, 2021
Cholesterol has gained tremendous attention as an essential lipid in the life cycle of virtually all viruses. These seem to have developed manifold strategies to modulate the cholesterol metabolism to the side of lipid uptake and de novo synthesis.
Mirco Glitscher, Eberhard Hildt
doaj   +1 more source

Prion protein interacts with bace1 and differentially regulates its activity towards wild type and swedish mutant amyloid precursor protein [PDF]

, 2011
In Alzheimer disease amyloid-β (Aβ) peptides derived from the amyloid precursor protein (APP) accumulate in the brain. Cleavage of APP by the β-secretase BACE1 is the rate-limiting step in the production of Aβ.
Andersen, Anthony J. Turner, Benjannet, Bennett, Bennett, Calella, Capell, Carolyn D. Jackson, Cole, Cole, Creemers, Debbie Brown, Fukumoto, Gimbel, Haass, Haugabook, Heledd H. Griffiths, Herbert Baybutt, Hooper, Huse, Isobel J. Whitehouse, Jean C. Manson, Katherine A.B. Kellett, Kawarabayashi, Kayed, Kayed, Li, Manson, Morrissette, Mucke, Mullan, Murrell, Nigel M. Hooper, Parkin, Pedro Piccardo, Piccardo, Schwarze-Eicker, Selkoe, Spoelgen, Sun, Thinakaran, Vardy, Vassar, Vassar, Walmsley, Walsh, Whitehouse, Yamakawa, Yan, Zhao   +49 more
core   +1 more source

Distinct Membrane Domains on Endosomes in the Recycling Pathway Visualized by Multicolor Imaging of Rab4, Rab5, and Rab11

Journal of Cell Biology, 2000
Two endosome populations involved in recycling of membranes and receptors to the plasma membrane have been described, the early and the recycling endosome.
B. Sönnichsen, Stefano De Renzis, E. Nielsen, J. Rietdorf, M. Zerial   +4 more
semanticscholar   +1 more source

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Recruitment of VPS33A to HOPS by VPS16 Is Required for Lysosome Fusion with Endosomes and Autophagosomes

Traffic : the International Journal of Intracellular Transport, 2015
The mammalian homotypic fusion and vacuole protein sorting (HOPS) complex is comprised of six subunits: VPS11, VPS16, VPS18, VPS39, VPS41 and the Sec1/Munc18 (SM) family member VPS33A.
Lena Wartosch, Ufuk Günesdogan, S. C. Graham, J. Luzio   +3 more
semanticscholar   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Nanoparticles for live cell microscopy: A surface-enhanced Raman scattering perspective. [PDF]

, 2017
Surface enhanced Raman scattering (SERS) nanoparticles are an attractive alternative to fluorescent probes for biological labeling because of their photostability and multiplexing capabilities.
Candas, Demet, Chan, James W, Chernenko, Tatyana, Fan, Ming, Li, Jian Jian, Mehrpouyan, Majid, Navas-Moreno, Maria, Yan, Ming   +7 more
core   +1 more source