Results 1 to 10 of about 15,258 (187)

Recombinant Human Endostatin Suppressed the Biological Behavior of Human Umbilical Vein Endothelial Cells Under Hypoxic and Hypoxic/Starvation Conditions In Vitro [PDF]

Analytical Cellular Pathology
Recombinant human endostatin (rh-endostatin) has been shown to act as an inhibitor of angiogenesis. Previous studies have indicated that rh-endostatin combined with chemotherapy can improve the objective response rate (ORR), time to progression (TTP ...
Yongsheng Jia, Cuicui Zhang, Jimin Zhao, Chuanxiang Hu, Xiaoyong Yang, Yan Zhang   +5 more
doaj   +2 more sources

Plasma endostatin and its association with new-onset acute kidney injury in critical care [PDF]

Journal of Intensive Care
Background Endostatin is a promising biomarker for predicting acute kidney injury (AKI) and mortality in the intensive care unit (ICU). We investigated plasma endostatin levels at ICU admission as predictors of new-onset AKI within 48 h after ICU ...
Hazem Koozi, Jonas Engström, Anders Larsson, Martin Spångfors, Hans Friberg, Attila Frigyesi   +5 more
doaj   +2 more sources

Plasma endostatin at intensive care admission is independently associated with acute kidney injury, dialysis, and mortality in COVID-19 [PDF]

Intensive Care Medicine Experimental
Background Critical COVID-19 is associated with high mortality, and acute kidney injury (AKI) is common. Endostatin has emerged as a promising prognostic biomarker for predicting AKI and mortality in intensive care. This study aimed to investigate plasma
Hazem Koozi, Jonas Engström, Ahmad Zwawi, Martin Spångfors, Ingrid Didriksson, Anders Larsson, Hans Friberg, Attila Frigyesi   +7 more
doaj   +2 more sources

Association between endostatin and mortality in patients with acute dyspnoea, with or without congestive heart failure: a single-centre, prospective, observational study [PDF]

BMJ Open
Objective The aim of this study was to assess associations between endostatin levels and short-term mortality in unsorted acute hospitalised dyspnoea patients with or without congestive heart failure (CHF), adjusted for common cardiovascular risk factors.
Axel C Carlsson, Caroline Heijl, Ardavan M Khoshnood, Alexander Yaghoubi, Per Erik Wändell, Torgny Wessman   +5 more
doaj   +2 more sources

The angiostatic peptide endostatin enhances mortality risk prediction in pulmonary arterial hypertension

ERJ Open Research, 2021
Currently available noninvasive markers for assessing disease severity and mortality risk in pulmonary arterial hypertension (PAH) are unrelated to fundamental disease biology.
Catherine E. Simpson, Megan Griffiths, Jun Yang, Melanie K. Nies, R. Dhananjay Vaidya, Stephanie Brandal, Lisa J. Martin, Michael W. Pauciulo, Katie A. Lutz, Anna W. Coleman, Eric D. Austin, D. Dunbar Ivy, William C. Nichols, Allen D. Everett, Paul M. Hassoun, Rachel L. Damico   +15 more
doaj   +1 more source

Endostatin's endpoints—Deciphering the endostatin antiangiogenic pathway [PDF]

Cancer Cell, 2004
Up until now, the precise mechanism for endostatin's antiangiogenesis action was not known. In a recent report, have taken advantage of gene array and proteomic analysis to map the antiangiogenic pathways turned on by endostatin. This study resolves some of the controversies surrounding endostatin's biology, and provides a new direction to help dissect
Benezra, Robert, Rafii, Shahin
openaire   +2 more sources

A Comparison between Endostatin and Conventional Biomarkers on 30-Day Mortality and Renal Replacement Therapy in Unselected Intensive Care Patients

Biomedicines, 2021
Endostatin may predict mortality and kidney impairment in general populations as well as in critically ill patients. We decided to explore the possible role of endostatin as a predictor of 30-day mortality, acute kidney injury (AKI), and renal ...
Toralph Ruge, Anders Larsson, Miklós Lipcsey, Jonas Tydén, Joakim Johansson, Mats Eriksson   +5 more
doaj   +1 more source

Unlocking biomarker discovery: Large scale application of aptamer proteomic technology for early detection of lung cancer [PDF]

, 2010
Lung cancer is the leading cause of cancer deaths, because ~84% of cases are diagnosed at an advanced stage. Worldwide in 2008, ~1.5 million people were diagnosed and ~1.3 million died – a survival rate unchanged since 1960.
Alex Stewart, Dom Zichi, Edward N. Brody, Harvey I. Pass, Jeffrey J. Walker, Jill M. Siegfried, Joel L. Weissfeld, Larry Gold, Mike Mehan, Rachel M. Ostroff, Stephen Williams, Wilbur Franklin, William L. Bigbee, William N. Rom, York E. Miller   +14 more
core   +15 more sources

An Endostatin-lentivirus (ES-LV)-EPC gene therapy agent for suppression of neovascularization in oxygen-induced retinopathy rat model

BMC Molecular and Cell Biology, 2020
Background Transplantation of gene transfected endothelial progenitor cells (EPCs) has provided novel methods for tumor neovascularization therapy but not for ocular disease therapy.
Jing Ai, Jian Ma, Zhi-Qing Chen, Jun-Hui Sun, Ke Yao   +4 more
doaj   +1 more source

Basement membrane product, endostatin, as a link between inflammation, coagulation and vascular permeability in COVID-19 and non-COVID-19 acute respiratory distress syndrome

Frontiers in Immunology, 2023
BackgroundImmune cell recruitment, endothelial cell barrier disruption, and platelet activation are hallmarks of lung injuries caused by COVID-19 or other insults which can result in acute respiratory distress syndrome (ARDS).
Katharina Jandl, Katharina Jandl, Johannes Lorenz Berg, Johannes Lorenz Berg, Anna Birnhuber, Anna Birnhuber, Elisabeth Fliesser, Izabela Borek, Benjamin Seeliger, Sascha David, Julius J. Schmidt, Gregor Gorkiewicz, Martin Zacharias, Tobias Welte, Horst Olschewski, Horst Olschewski, Akos Heinemann, Malgorzata Wygrecka, Malgorzata Wygrecka, Grazyna Kwapiszewska, Grazyna Kwapiszewska, Grazyna Kwapiszewska   +21 more
doaj   +1 more source