Results 11 to 20 of about 15,277 (204)

Elevated Endostatin Expression Is Regulated by the pIgA Immune Complex and Associated with Disease Severity of IgA Nephropathy

Kidney & Blood Pressure Research, 2020
Background/Aims: Renal vascular injury accounts for the poor outcomes of patients with IgA nephropathy (IgAN). In this study, we investigated whether endostatin, a potent inhibitor of angiogenesis, is associated with IgAN.
Yaling Zhai, Xiaoqing Long, Jingge Gao, Xingchen Yao, Xinnian Wang, Zhanzheng Zhao   +5 more
doaj   +1 more source

The Roles of Vascular Endothelial Growth Factor, Angiostatin, and Endostatin in Nasal Polyp Development [PDF]

Journal of Rhinology, 2022
Background and Objectives Microvascular remodeling and angiogenesis are elements of tissue remodeling characteristic of chronic inflammatory diseases, including nasal polyps (NPs).
Tae Ui Hong, Seong Kook Park
doaj   +1 more source

Endostatin induces normalization of blood vessels in colorectal cancer and promotes infiltration of CD8+ T cells to improve anti-PD-L1 immunotherapy

Frontiers in Immunology, 2022
IntroductionThe purpose of this study was to evaluate recombinant human endostatin (rHE)-induced normalization of the tumor vasculature in colorectal cancer (CRC) and to evaluate the therapeutic effects of combined treatment with rHE and a programmed ...
Xiao-Dong Chu, Hui Bao, Yu-Jian Lin, Ruo-Xi Chen, Yi-Ran Zhang, Ting Huang, Jia-Shuai He, Shu-Chen Huangfu, Yun-Long Pan, Hui Ding   +9 more
doaj   +1 more source

Angiogenic and angiostatic factors in renal scleroderma-associated vasculopathy [PDF]

, 2017
BACKGROUND: The angiogenesis in systemic sclerosis (SSc) is impaired. An imbalance of pro-angiogenic factors and angiogenesis inhibitors has been implicated in the progression of peripheral microvascular damage, defective vascular repair and fibrosis ...
Afeltra, Antonella M. Vittoria, Amoroso, Antonio, Barbano, Biagio, Cianci, Rosario, Gigante, Antonietta, Margiotta, Domenico, Navarini, Luca, Rosato, Edoardo   +7 more
core   +1 more source

Endostatin gene variation and protein levels in breast cancer susceptibility and severity

BMC Cancer, 2007
Background Endostatin is a potent endogenous anti-angiogenic agent which inhibits tumour growth. A non-synonymous coding polymorphism in the Endostatin gene is thought to affect Endostatin activity.
Cox Angela, Globe Jenny, Cross Simon S, Balasubramanian Sabapathy P, Brown Nicola J, Reed Malcolm W   +5 more
doaj   +1 more source

Development of 'Redox Arrays' for identifying novel glutathionylated proteins in the secretome [PDF]

, 2015
Proteomics techniques for analysing the redox status of individual proteins in complex mixtures tend to identify the same proteins due to their high abundance.
Bottazzi, Barbara, Chan, Philippe, Ghezzi, Pietro, Hammouz, Raneem, Mullen, Lisa, Seavill, Miles, Vaudry, David   +6 more
core   +1 more source

Platelets and galectins [PDF]

, 2014
A major function of platelets is keeping the vascular system intact. Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug.
Schattner, Mirta Ana
core   +1 more source

Intervertebral Disc Proteoglycans: Multifunctional Tissue Stabilizing and Instructional Cell Regulatory Proteins That Control Tissue Homeostasis. [PDF]

JOR Spine
Matrix and cell‐associated proteoglycans are important tissue‐stabilizing, weight‐bearing, and tension‐resisting proteins in the intervertebral disc. Their glycosaminoglycan components have growth factor binding and cell‐instructive properties that allow cells to regulate tissue composition and function.
Melrose J.
europepmc   +2 more sources

SMARCA4-Deficient Undifferentiated Thoracic Tumor: Clinical Features and Prognosis of a Case Series and Literature Review. [PDF]

Clin Respir J
Our manuscript presents detailed presentations of case series of thoracic SMARCA4‐UT, and we report a unique case of diaphragmatic metastases and, interestingly, the occurrence of brain metastasis in one patient, which is a rare phenomenon in SMARCA4‐UT.
Shan F, Liang S, Zhang Y, Wu W, Yang G, Yan M, Zhang X, Miao Y, Liu L, Cai J, Shi Z, Liu B, Zhang N.   +12 more
europepmc   +2 more sources

Real‐world outcomes of various regimens of recombinant human endostatin combined with chemotherapy in non‐driver gene mutation advanced non‐small cell lung cancer

Cancer Medicine, 2019
Aims This real‐world study is conducted to evaluate the efficacy and safety of recombinant human endostatin (rh‐endostatin) combined with chemotherapy as first‐line treatment for non‐driver genes mutation non‐small cell lung cancer (NSCLC) patients, and ...
Zhongtai Wang, Hui Zhang, Chunhua Zhou, Xiaoyan Long, Rui Guan, Nong Yang, Yongchang Zhang   +6 more
doaj   +1 more source