Mechanisms and Clinical Implications of Endothelial Dysfunction in Arterial Hypertension
Journal of Cardiovascular Development and Disease, 2022 The endothelium is composed of a monolayer of endothelial cells, lining the interior surface of blood and lymphatic vessels. Endothelial cells display important homeostatic functions, since they are able to respond to humoral and hemodynamic stimuli ...
Pasquale Ambrosino +9 more
doaj +1 more source
Coronary artery endothelial dysfunction is positively correlated with low density lipoprotein and inversely correlated with high density lipoprotein subclass particles measured by nuclear magnetic resonance spectroscopy. [PDF]
, 2009 OBJECTIVE: The association between cholesterol and endothelial dysfunction remains controversial. We tested the hypothesis that lipoprotein subclasses are associated with coronary endothelial dysfunction.
Abhiram Prasad +42 more
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Diabetes mellitus and ischemic heart disease. the role of ion channels [PDF]
, 2018 Diabetes mellitus is one the strongest risk factors for cardiovascular disease and, in particular, for ischemic heart disease (IHD). The pathophysiology of myocardial ischemia in diabetic patients is complex and not fully understood: some diabetic ...
De Marchis, Marialaura +8 more
core +9 more sources
The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD [PDF]
, 2016 Objective The balance between coronary endothelial dysfunction and repair is influenced by many protective and deleterious factors circulating in the blood.
Ahmed, Nadeem +7 more
core +1 more source
Levels of protein C and soluble thrombomodulin in critically ill patients with acute kidney injury: a multicenter prospective observational study. [PDF]
, 2015 Endothelial dysfunction contributes to the development of acute kidney injury (AKI) in animal models of ischemia reperfusion injury and sepsis. There are limited data on markers of endothelial dysfunction in human AKI. We hypothesized that Protein C (PC)
Berg, David T +10 more
core +12 more sources
INSULIN RESISTANCE AND ENDOTHELIAL DYSFUNCTION IN RHEUMATOID ARTHRITIS [PDF]
Romanian Journal of Rheumatology, 2016 Rheumatoid arthritis is a chronic inflammatory disease, in which, besides articular involvement, cardiovascular complications due to premature and accelerated atherosclerosis represent a serious problem.
Alexandru Caraba +3 more
doaj +1 more source
Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood-brain barrier dysfunction module. [PDF]
, 2019 Blood vessels in the CNS form a specialized and critical structure, the blood-brain barrier (BBB). We present a resource to understand the molecular mechanisms that regulate BBB function in health and dysfunction during disease.
Aydin, Sidar +16 more
core +1 more source
T-cadherin deficiency increases vascular vulnerability in T2DM through impaired NO bioactivity. [PDF]
, 2017 BACKGROUND: Endothelial dysfunction plays a critical role in the development of type 2 diabetes (T2DM). T-cadherin (T-cad) has gained recognition as a regulator of endothelial cell (EC) function.
Ambrosio, Anastasia +7 more
core +2 more sources
Mechanisms of endothelial cell dysfunction in cystic fibrosis [PDF]
, 2017 Although cystic fibrosis (CF) patients exhibit signs of endothelial perturbation, the functions of the cystic fibrosis conductance regulator (CFTR) in vascular endothelial cells (EC) are poorly defined.
Anile, Marco +22 more
core +1 more source
Experimental models for vascular endothelial dysfunction
Bangladesh Journal of Pharmacology, 2021 Vascular endothelial dysfunction is characterized by apoptosis of endothelial cells, an imbalance between vasoconstrictory and vasodilatory substances, the imbalance between ROS and antioxidants, vascular remodeling, loss of vascular integrity which ...
Anchal Garg +3 more
doaj +1 more source