Results 41 to 50 of about 1,223,204 (255)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Inflammation and endothelial dysfunction with aging

, 2010
Aging is an independent risk factor for cardiovascular disease that is associated with chronic inflammation. The turnover of the endothelial layer is accelerated in aged subjects and endothelial dysfunction is observed after regeneration.
Vanhoutte, PMGR, Lee, MYK
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Endothelial Dysfunction and SARS-CoV-2 Infection: Association and Therapeutic Strategies

Pathogens, 2021
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), has been recently considered a systemic disorder leading to the procoagulant state.
Hai Deng, Ting-Xuan Tang, Deng Chen, Liang-Sheng Tang, Xiang-Ping Yang, Zhao-Hui Tang   +5 more
doaj   +1 more source

Endothelial dysfunction in nonalcoholic fatty liver disease

One Health & Risk Management, 2022
Introduction. The prevalence of nonalcoholic fatty liver disease (NAFLD) in western countries is increasing rapidly and is considered as component of metabolic syndrome.
Angela PELTEC, Murad ALNABGHALIE
doaj   +1 more source

Peptide Bbeta(15-42) preserves endothelial barrier function in shock [PDF]

, 2009
Loss of vascular barrier function causes leak of fluid and proteins into tissues, extensive leak leads to shock and death. Barriers are largely formed by endothelial cell-cell contacts built up by VE-cadherin and are under the control of RhoGTPases. Here
George Ignatyev, Sonja Reingruber, Hofer-Warbinek, Renate, Ulrich Matt, Atrasheuskaya, Alena, Waltraud Pasteiner, Ignatyev, George, Gröger, Marion, Zacharowski, Kai, Reingruber, Sonja, Petzelbauer, Peter, Renate Hofer-Warbinek, Friedl, Peter, Zinkl, Daniela, Peter Petzelbauer, Pasteiner, Waltraud, Knapp, Sylvia, Alena Atrasheuskaya, Bukin, Eugenij, Eugenij Bukin, Matt, Ulrich, Kai Zacharowski, Sylvia Knapp, Peter Friedl, Marion Gröger, Daniela Zinkl   +25 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Endothelial Dysfunction in Patients Undergoing Cardiac Surgery: A Narrative Review and Clinical Implications

Journal of Cardiovascular Development and Disease, 2023
Cardiac surgery is one of the highest-risk procedures, usually involving cardiopulmonary bypass and commonly inducing endothelial injury that contributes to the development of perioperative and postoperative organ dysfunction.
Danijel Knežević, Božena Ćurko-Cofek, Tanja Batinac, Gordana Laškarin, Marijana Rakić, Maja Šoštarič, Marko Zdravković, Alan Šustić, Vlatka Sotošek, Lara Batičić   +9 more
doaj   +1 more source