Results 41 to 50 of about 403,263 (261)

Role of free fatty acids in endothelial dysfunction

Journal of Biomedical Science, 2017
Plasma free fatty acids levels are increased in subjects with obesity and type 2 diabetes, playing detrimental roles in the pathogenesis of atherosclerosis and cardiovascular diseases.
Arijit Ghosh, Lei Gao, Abhimanyu Thakur, Parco M. Siu, Christopher W. K. Lai   +4 more
doaj   +1 more source

Endothelial Dysfunction in Patients Undergoing Cardiac Surgery: A Narrative Review and Clinical Implications

Journal of Cardiovascular Development and Disease, 2023
Cardiac surgery is one of the highest-risk procedures, usually involving cardiopulmonary bypass and commonly inducing endothelial injury that contributes to the development of perioperative and postoperative organ dysfunction.
Danijel Knežević, Božena Ćurko-Cofek, Tanja Batinac, Gordana Laškarin, Marijana Rakić, Maja Šoštarič, Marko Zdravković, Alan Šustić, Vlatka Sotošek, Lara Batičić   +9 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Endothelial dysfunction in nonalcoholic fatty liver disease

One Health & Risk Management, 2022
Introduction. The prevalence of nonalcoholic fatty liver disease (NAFLD) in western countries is increasing rapidly and is considered as component of metabolic syndrome.
Angela PELTEC, Murad ALNABGHALIE
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Association of Monocyte-to-HDL Cholesterol Ratio with Endothelial Dysfunction in Patients with Type 2 Diabetes

Journal of Diabetes Research
Aims. To explore the relationship between monocyte-to-HDL cholesterol ratio (MHR) and endothelial function in patients with type 2 diabetes (T2DM). Methods. 243 patients diagnosed with T2DM were enrolled in this cross-sectional study.
Huihui Zhang, Jun Lu, Jie Gao, Wenjun Sha, Xinhua Cai, Mai Re Yan Mu Rouzi, Yuanying Xu, Wenjun Tang, Tao Lei   +8 more
doaj   +1 more source

Endothelial Dysfunction in Hypertension

Clinical and Experimental Hypertension, 1999
Hypertension is an important risk factor for the development of atherosclerosis and endothelial dysfunction may be a key mechanism. The nitric oxide mediated vasodilator function of the endothelium has been widely studied as a test of endothelial integrity in patients with hypertension and impaired basal and muscarinic agonist stimulated components of ...
openaire   +3 more sources

Endothelial Dysfunction in HIV

, 2011
Vani Subbarao1, David Lowe2,3, Reza Aghamohammadzadeh4,5 and Robert J. Wilkinson2,3,6 1Madwaleni Hospital, Elliotdale, Eastern Cape 2Clinical Infectious Disease Research Initiative, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town 3Wellcome Trust Centre for Research in Clinical Tropical Medicine, Department of Medicine ...
Subbarao, Vani, Lowe, David, Aghamohammadzadeh, Reza, Wilkinson, Robert   +3 more
openaire   +3 more sources