Results 31 to 40 of about 1,223,204 (255)

Metabolic systems analysis of LPS induced endothelial dysfunction applied to sepsis patient stratification

Scientific Reports, 2018
Endothelial dysfunction contributes to sepsis outcome. Metabolic phenotypes associated with endothelial dysfunction are not well characterised in part due to difficulties in assessing endothelial metabolism in situ.
Sarah McGarrity, Ósk Anuforo, Haraldur Halldórsson, Andreas Bergmann, Skarphéðinn Halldórsson, Sirus Palsson, Hanne H. Henriksen, Pär Ingemar Johansson, Óttar Rolfsson   +8 more
doaj   +1 more source

Endothelial Function in Dyslipidemia: Roles of LDL-Cholesterol, HDL-Cholesterol and Triglycerides

Cells, 2023
Dyslipidemia is associated with endothelial dysfunction. Endothelial dysfunction is the initial step for atherosclerosis, resulting in cardiovascular complications.
Yukihito Higashi
doaj   +1 more source

SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice [PDF]

, 2010
Excessive production of reactive oxygen species (ROS) contributes to progression of atherosclerosis, at least in part by causing endothelial dysfunction and inflammatory activation. The class III histone deacetylase SIRT1 has been implicated in extension
Handschin, C, Heinrich, Kathrin, Schäfer, N, Heinrich, K, Winnik, Stephan, Matter, Christian M., Brokopp, Chad E., Tanner, F C, Tanner, Felix C., Landmesser, Ulf, Breitenstein, A, Handschin, Christoph, Stein, Sokrates, Landmesser, U, Lüscher, Thomas F., Breitenstein, Alexander, Schäfer, Nicola, Besler, C, Winnik, S, Lohmann, C, Lüscher, T F, Lohmann, Christine, Besler, Christian, Matter, C M, Brokopp, C E, Stein, S   +25 more
core   +1 more source

Endothelial Dysfunction and the Effect of Arginine and Citrulline Supplementation in Children and Adolescents With Mitochondrial Diseases

Journal of Central Nervous System Disease, 2020
Background: In addition to the reduced energy production, characteristic of mitochondrial disorders, nitric oxide (NO) deficiency can occur as well. The NO produced by vascular endothelial cells relaxes vascular smooth muscles, resulting in vasodilation ...
Fatma Al Jasmi, Nuha Al Zaabi, Khalid Al-Thihli, Amal M Al Teneiji, Jozef Hertecant, Ayman W El-Hattab   +5 more
doaj   +1 more source

The uremic toxin hippurate promotes endothelial dysfunction via the activation of Drp1-mediated mitochondrial fission

Redox Biology, 2018
The accumulation of uremic toxins in chronic kidney disease (CKD) induces inflammation, oxidative stress and endothelial dysfunction, which is a key step in atherosclerosis.
Mengjie Huang, Ribao Wei, Yang Wang, Tingyu Su, Ping Li, Xiangmei Chen   +5 more
doaj   +1 more source

Overview of the Assessment of Endothelial Function in Humans

Frontiers in Medicine, 2020
The endothelium is recognized to play an important role in various physiological functions including vascular tone, permeability, anticoagulation, and angiogenesis.
Po Ying Chia, Po Ying Chia, Po Ying Chia, Andrew Teo, Andrew Teo, Tsin Wen Yeo, Tsin Wen Yeo, Tsin Wen Yeo   +7 more
doaj   +1 more source

Endothelial dysfunction assessed by brachial artery flow-mediated dilatation predicts severe COVID-19-related disease

Journal of Family Medicine and Primary Care, 2022
Background: Endothelial dysfunction, inflammation, and hypercoagulability are hallmarks of severe COVID-19 related disease. Endothelial function can be measured non-invasively by flow-mediated dilatation in the brachial artery.
Rohit Walia, Venkat Subaih Arunachalam, Udit Chauhan, Meenakshi Khapre, Poonam Arora   +4 more
doaj   +1 more source

Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches [PDF]

, 2022
Dear colleagues, This Special Issue, “Endothelial Dysfunction: From Pathophysiology to Novel Therapeutic Approaches”, focuses on the pathophysiology of endothelial dysfunction, new biomarkers for endothelial dysfunction related to cardiovascular ...

core   +1 more source

Significance of Endothelial Dysfunction Amelioration for Sodium–Glucose Cotransporter 2 Inhibitor-Induced Improvements in Heart Failure and Chronic Kidney Disease in Diabetic Patients

Metabolites, 2023
Beyond lowering plasma glucose levels, sodium–glucose cotransporter 2 inhibitors (SGLT2is) significantly reduce hospitalization for heart failure (HF) and retard the progression of chronic kidney disease (CKD) in patients with type 2 diabetes ...
Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama   +3 more
doaj   +1 more source

Endothelial dysfunction as a pathogenetic factor in cardiovascular diseases

, 2022
Cardiovascular disease (CVD) is a major cause of morbidity and mortality around the world. The risk factors and treatments have been thoroughly researched and documented, but one crucial element is endothelial dysfunction.
Elhayes, Sarah
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