Results 1 to 10 of about 27,105 (199)

High salt intake and HIV infection on endothelial glycocalyx shedding in salt-sensitive hypertension [PDF]

Frontiers in Cell and Developmental Biology
The endothelial glycocalyx is closely associated with various physiological and pathophysiological events. Significant modification of the endothelial glycocalyx is an early process in the pathogenesis of cardiovascular disease. High dietary salt and HIV
Sepiso K. Masenga, Sepiso K. Masenga, Situmbeko Liweleya, Annet Kirabo, Annet Kirabo, Annet Kirabo, Annet Kirabo   +6 more
doaj   +4 more sources

Fluid shear stress-dependent modulation of the basal endothelial glycocalyx. [PDF]

PLoS ONE
The vascular endothelial glycocalyx is a major regulator of endothelium function, serving as a vital mechanotransducer and barrier. Shear stress due to blood flow exerted on the apical endothelial cell (EC) and glycocalyx have been the primary focus of ...
Zoe Vittum, Solomon A Mensah
doaj   +2 more sources

The endothelial glycocalyx in critical illness: A pediatric perspective

Matrix Biology Plus, 2022
The vascular endothelium is the interface between circulating blood and end organs and thus has a critical role in preserving organ function. The endothelium is lined by a glycan-rich glycocalyx that uniquely contributes to endothelial function through ...
Robert P. Richter, Gregory A. Payne, Namasivayam Ambalavanan, Amit Gaggar, Jillian R. Richter   +4 more
doaj   +2 more sources

The Endothelial Glycocalyx in Pig-to-Baboon Cardiac Xenotransplantation—First Insights [PDF]

Biomedicines
Cardiac xenotransplantation has seen remarkable success in recent years and is emerging as the most promising alternative to human cardiac allotransplantation.
Martin Bender, Jan-Michael Abicht, Bruno Reichart, Maria Leuschen, Felicia Wall, Julia Radan, Elisabeth Neumann, Maren Mokelke, Ines Buttgereit, Sebastian Michel, Reinhard Ellgass, Katja Gieseke, Stig Steen, Audrius Paskevicius, Joachim Denner, Antonia W. Godehardt, Ralf R. Tönjes, Christian Hagl, David Ayares, Eckhard Wolf, Michael Schmoeckel, Paolo Brenner, Martin B. Müller, Matthias Längin   +23 more
doaj   +2 more sources

Endothelial glycocalyx degradation during sepsis: Causes and consequences

Matrix Biology Plus, 2021
The glycocalyx is a ubiquitous structure found on endothelial cells that extends into the vascular lumen. It is enriched in proteoglycans, which are proteins attached to the glycosaminoglycans heparan sulfate, chondroitin sulfate, dermatan sulfate ...
Ryan C. Sullivan, Matthew D. Rockstrom, Eric P. Schmidt, Joseph A. Hippensteel   +3 more
doaj   +1 more source

The endothelial glycocalyx—All the same? No, it is not

Acute Medicine & Surgery, 2023
The endothelial glycocalyx covers the lumen of blood vessels throughout the body and plays an important role in endothelial homeostasis. Advances in electron microscopy techniques have provided clues to better understand the structure and composition of ...
Kodai Suzuki, Tomotaka Miura, Hideshi Okada   +2 more
doaj   +1 more source

Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NF-κB/HPSE1 Signaling Pathway During Inflammation

Frontiers in Pharmacology, 2022
Tetramethylpyrazine (TMP), a Chinese traditional herbal extraction widely used in treating cardiovascular diseases, could attenuate vascular endothelial injuries, but the underlying mechanism remains incomprehensive.
Jin Lei, Jin Lei, Peng Xiang, Peng Xiang, Shengmei Zeng, Shengmei Zeng, Le Chen, Le Chen, Lei Zhang, Lei Zhang, Zhiyi Yuan, Zhiyi Yuan, Jun Zhang, Jun Zhang, Tingting Wang, Tingting Wang, Ruihong Yu, Ruihong Yu, Wanping Zhang, Wanping Zhang, Issa Issoufou Ibrahim, Issa Issoufou Ibrahim, Limei Ma, Limei Ma, Chao Yu, Chao Yu   +25 more
doaj   +1 more source

The Endothelial Glycocalyx: A Possible Therapeutic Target in Cardiovascular Disorders

Frontiers in Cardiovascular Medicine, 2022
The physiological, anti-inflammatory, and anti-coagulant properties of endothelial cells (ECs) rely on a complex carbohydrate-rich layer covering the luminal surface of ECs, called the glycocalyx.
Anastasia Milusev, Anastasia Milusev, Robert Rieben, Nicoletta Sorvillo   +3 more
doaj   +1 more source

Glycocalyx Impairment in Vascular Disease: Focus on Inflammation

Frontiers in Cell and Developmental Biology, 2021
The glycocalyx is a complex polysaccharide-protein layer lining the lumen of vascular endothelial cells. Changes in the structure and function of the glycocalyx promote an inflammatory response in blood vessels and play an important role in the ...
Jing Qu, Yue Cheng, Wenchao Wu, Lixing Yuan, Xiaojing Liu, Xiaojing Liu   +5 more
doaj   +1 more source

A low molecular weight heparin inhibits experimental metastasis in mice independently of the endothelial glycocalyx. [PDF]

PLoS ONE, 2010
BACKGROUND: Some low molecular weight heparins (LMWHs) prolong survival of cancer patients and inhibit experimental metastasis. The underlying mechanisms are still not clear but it has been suggested that LMWHs (at least in part) limit metastasis by ...
Geerte L Van Sluis, Max Nieuwdorp, Pieter W Kamphuisen, Johan van der Vlag, Cornelis J F Van Noorden, C Arnold Spek   +5 more
doaj   +1 more source