Results 1 to 10 of about 571,172 (234)

The endothelial glycocalyx—All the same? No, it is not [PDF]

Acute Medicine & Surgery, 2023
The endothelial glycocalyx covers the lumen of blood vessels throughout the body and plays an important role in endothelial homeostasis. Advances in electron microscopy techniques have provided clues to better understand the structure and composition of ...
Kodai Suzuki, Tomotaka Miura, Hideshi Okada   +2 more
doaj   +3 more sources

High salt intake and HIV infection on endothelial glycocalyx shedding in salt-sensitive hypertension [PDF]

Frontiers in Cell and Developmental Biology
The endothelial glycocalyx is closely associated with various physiological and pathophysiological events. Significant modification of the endothelial glycocalyx is an early process in the pathogenesis of cardiovascular disease. High dietary salt and HIV
Sepiso K. Masenga, Sepiso K. Masenga, Situmbeko Liweleya, Annet Kirabo, Annet Kirabo, Annet Kirabo, Annet Kirabo   +6 more
doaj   +3 more sources

The endothelial glycocalyx in critical illness: A pediatric perspective

Matrix Biology Plus, 2022
The vascular endothelium is the interface between circulating blood and end organs and thus has a critical role in preserving organ function. The endothelium is lined by a glycan-rich glycocalyx that uniquely contributes to endothelial function through ...
Robert P. Richter, Gregory A. Payne, Namasivayam Ambalavanan, Amit Gaggar, Jillian R. Richter   +4 more
doaj   +3 more sources

Endothelial CXCR2 deficiency attenuates renal inflammation and glycocalyx shedding through NF-κB signaling in diabetic kidney disease [PDF]

Cell Communication and Signaling
Background The incidence of diabetic kidney disease (DKD) continues to rapidly increase, with limited available treatment options. One of the hallmarks of DKD is persistent inflammation, but the underlying molecular mechanisms of early diabetic kidney ...
Siyuan Cui, Xin Chen, Jiayu Li, Wei Wang, Deqi Meng, Shenglong Zhu, Shiwei Shen   +6 more
doaj   +3 more sources

Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes [PDF]

Cardiovascular Diabetology
Background Diabetes mellitus is a chronic disease which is detrimental to cardiovascular health, often leading to secondary microvascular complications, with huge global health implications.
Monica Gamez, Hesham E. Elhegni, Sarah Fawaz, Kwan Ho Ho, Neill W. Campbell, David A. Copland, Karen L. Onions, Matthew J. Butler, Elizabeth J. Wasson, Michael Crompton, Raina D. Ramnath, Yan Qiu, Yu Yamaguchi, Kenton P. Arkill, David O. Bates, Jeremy E. Turnbull, Olga V. Zubkova, Gavin I. Welsh, Denize Atan, Simon C. Satchell, Rebecca R. Foster   +20 more
doaj   +3 more sources

The Endothelial Glycocalyx: A Possible Therapeutic Target in Cardiovascular Disorders

Frontiers in Cardiovascular Medicine, 2022
The physiological, anti-inflammatory, and anti-coagulant properties of endothelial cells (ECs) rely on a complex carbohydrate-rich layer covering the luminal surface of ECs, called the glycocalyx.
Anastasia Milusev, Anastasia Milusev, Robert Rieben, Nicoletta Sorvillo   +3 more
doaj   +2 more sources

Endothelial Glycocalyx Degradation in Critical Illness and Injury

Frontiers in Medicine, 2022
The endothelial glycocalyx is a gel-like layer on the luminal side of blood vessels that is composed of glycosaminoglycans and the proteins that tether them to the plasma membrane.
Eric K. Patterson, Gediminas Cepinskas, Gediminas Cepinskas, Douglas D. Fraser, Douglas D. Fraser, Douglas D. Fraser, Douglas D. Fraser, Douglas D. Fraser   +7 more
doaj   +2 more sources

Tetramethylpyrazine Alleviates Endothelial Glycocalyx Degradation and Promotes Glycocalyx Restoration via TLR4/NF-κB/HPSE1 Signaling Pathway During Inflammation

Frontiers in Pharmacology, 2022
Tetramethylpyrazine (TMP), a Chinese traditional herbal extraction widely used in treating cardiovascular diseases, could attenuate vascular endothelial injuries, but the underlying mechanism remains incomprehensive.
Jin Lei, Jin Lei, Peng Xiang, Peng Xiang, Shengmei Zeng, Shengmei Zeng, Le Chen, Le Chen, Lei Zhang, Lei Zhang, Zhiyi Yuan, Zhiyi Yuan, Jun Zhang, Jun Zhang, Tingting Wang, Tingting Wang, Ruihong Yu, Ruihong Yu, Wanping Zhang, Wanping Zhang, Issa Issoufou Ibrahim, Issa Issoufou Ibrahim, Limei Ma, Limei Ma, Chao Yu, Chao Yu   +25 more
doaj   +2 more sources

Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19 [PDF]

Molecular Medicine, 2021
Background We investigated the feasibility of two biomarkers of endothelial damage (Syndecan-1 and thrombomodulin) in coronavirus disease 2019 (COVID-19), and their association with inflammation, coagulopathy, and mortality.
Dong Zhang, Liubing Li, Yu Chen, Jie Ma, Yanli Yang, Surita Aodeng, Qiuju Cui, Kedi Wen, Meng Xiao, Jing Xie, Yingchun Xu, Yongzhe Li   +11 more
openalex   +2 more sources

Endothelial Glycocalyx Preservation-Impact of Nutrition and Lifestyle. [PDF]

Nutrients, 2023
The endothelial glycocalyx (eGC) is a dynamic hair-like layer expressed on the apical surface of endothelial cells throughout the vascular system. This layer serves as an endothelial cell gatekeeper by controlling the permeability and adhesion properties
Franceković P, Gliemann L.
europepmc   +2 more sources