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Restrictive Versus Standard Intravenous Fluid Therapy and Endothelial Glycocalyx Shedding in ICU Patients With Septic Shock-A Preplanned Sub-Study of the Randomized CLASSIC Trial. [PDF]
Acta Anaesthesiol ScandChristensen J +13 more
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Sex differences in endothelial glycocalyx thickness and the response to glycocalyx-targeted therapy among older adults. [PDF]
Physiol RepGimblet CJ +3 more
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The Endothelial Glycocalyx: Composition, Functions, and Visualization [PDF]
Pflugers Archiv European Journal of Physiology, 2007 This review aims at presenting state-of-the-art knowledge on the composition and functions of the endothelial glycocalyx. The endothelial glycocalyx is a network of membrane-bound proteoglycans and glycoproteins, covering the endothelium luminally.
Mirjam Oude Egbrink +2 more
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Derangement of the Endothelial Glycocalyx in Sepsis [PDF]
Journal of Thrombosis and Haemostasis, 2019 The vascular endothelial surface is coated by the glycocalyx, a ubiquitous gel-like layer composed of a membrane-binding domain that contains proteoglycans, glycosaminoglycan side-chains, and plasma proteins such as albumin and antithrombin. The endothelial glycocalyx plays a critical role in maintaining vascular homeostasis. However, this component is
Toshiaki Iba +2 more
exaly +3 more sources
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Comprehensive Physiology, 2022
Abstract The glycocalyx is a polysaccharide structure that protrudes from the body of a cell. It is primarily conformed of glycoproteins and proteoglycans, which provide communication, electrostatic charge, ionic buffering, permeability, and mechanosensation‐mechanotransduction capabilities to cells.
Christopher A, Foote +7 more
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Abstract The glycocalyx is a polysaccharide structure that protrudes from the body of a cell. It is primarily conformed of glycoproteins and proteoglycans, which provide communication, electrostatic charge, ionic buffering, permeability, and mechanosensation‐mechanotransduction capabilities to cells.
Christopher A, Foote +7 more
openaire +2 more sources
Critical Care Clinics, 2020
The endothelial glycocalyx (EG) is the most luminal layer of the blood vessel, growing on and within the vascular wall. Shedding of the EG plays a central role in many critical illnesses. Degradation of the EG is associated with increased morbidity and mortality. Certain illnesses and iatrogenic interventions can cause degradation of the EG.
Jan, Jedlicka +2 more
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The endothelial glycocalyx (EG) is the most luminal layer of the blood vessel, growing on and within the vascular wall. Shedding of the EG plays a central role in many critical illnesses. Degradation of the EG is associated with increased morbidity and mortality. Certain illnesses and iatrogenic interventions can cause degradation of the EG.
Jan, Jedlicka +2 more
openaire +2 more sources
In Vivo Imaging of the Cerebral Endothelial Glycocalyx in Mice
Journal of Vascular Research, 2017 <b><i>Background/Aims:</i></b> Endothelial glycocalyx refers to the proteoglycan or glycoprotein layer of vessel walls and has critical physiological functions.
Yong Jeong, Jin-Hui Yoon, Eek-Sung Lee
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Trauma and Endothelial Glycocalyx
Shock, 2016Trauma represents a remarkable social and economical burden, being a leading cause of death and morbidity in the young population. The Endothelial Glycocalyx (EG) is a web of membrane bound to the luminal side of the blood vessels endothelium. Its role includes maintenance of the vascular permeability barrier and mediation of shear response.
Mazin, Tuma +3 more
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Endothelial Cell Glycocalyx Modulates Immobilization of Leukocytes at the Endothelial Surface [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2003 Objective— A thick endothelial glycocalyx provides the endothelial surface with a nonadherent shield. Oxidized LDL (Ox-LDL) degrades the endothelial glycocalyx. We hypothesized that glycocalyx degradation stimulates leukocyte-endothelial cell adhesion, whereas intravascular supplementation with ...
Hans Vink, Jos Spaan
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Impairment of endothelial glycocalyx in atherosclerosis and obesity
2023Endothelial glycocalyx is a negatively charged gel-like layer located on the apical surface of endothelial cells. It serves as a selective two-way physical barrier between the flowing blood and the endothelium, which regulates the access of macromolecules and of blood cells to the endothelial surface.
Sang Joon, Ahn +3 more
openaire +2 more sources