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Therapeutic strategies targeting the endothelial glycocalyx
Current Opinion in Clinical Nutrition & Metabolic Care, 2023Purpose of review This review will highlight recent studies that have examined the endothelial glycocalyx in a variety of health conditions, as well as potential glycocalyx-targeted therapies. Recent findings A degraded glycocalyx is present in individuals that consume high sodium ...
Daniel R, Machin +3 more
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Endothelial Glycocalyx Turnover in Vascular Health and Disease: Rethinking Endothelial Dysfunction
Annual Review of BiochemistryThe endothelial glycocalyx, a glycan-rich layer on the luminal surface of endothelial cells lining blood and lymphatic vessels, plays a crucial role in vascular homeostasis by regulating vascular permeability, immune cell trafficking, and vascular tone ...
Jeffrey Esko +2 more
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Endothelial Glycocalyx and the Peritoneal Barrier
Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 2008Recent advances in the study of the microcirculation have demonstrated the critical role of the endothelial glycocalyx in transcapillary transport from the plasma to the tissue interstitium. Since the capillary wall represents the initial resistance to solute transfer from the plasma through the tissue to the dialysate, the glycocalyx is potentially of
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Endothelial glycocalyx shedding in patients with burns
Burns, 2020Shedding of syndecan-1 from the endothelial glycocalyx layer (EGL), referred to as endotheliopathy of trauma (EoT), is associated with poorer outcomes. This study aims to determine if EoT is also present in the burn population. We enrolled 458 burn and non-burn trauma patients at a Level 1 trauma center and defined EoT by a syndecan-1 level of ≥40 ng ...
Welling, Harald +6 more
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American Journal of Physiology-Heart and Circulatory Physiology, 2023
Vascular endothelial cells represent the first line of exposure to bacterial endotoxins. Here, we propose a novel therapeutic strategy using liposomes to deliver preassembled glycocalyx to vascular endothelial cell surface and consequently restore endothelial glycocalyx (EG).
Shinya Ishiko +4 more
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Vascular endothelial cells represent the first line of exposure to bacterial endotoxins. Here, we propose a novel therapeutic strategy using liposomes to deliver preassembled glycocalyx to vascular endothelial cell surface and consequently restore endothelial glycocalyx (EG).
Shinya Ishiko +4 more
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The Structure and Function of the Endothelial Glycocalyx Layer
Annual Review of Biomedical Engineering, 2007Over the past decade, since it was first observed in vivo, there has been an explosion in interest in the thin (∼500 nm), gel-like endothelial glycocalyx layer (EGL) that coats the luminal surface of blood vessels. In this review, we examine the mechanical and biochemical properties of the EGL and the latest studies on the interactions of this layer ...
Sheldon, Weinbaum +2 more
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The glycocalyx and calcium dynamics in endothelial cells
2023The endothelial glycocalyx is a dynamic surface layer composed of proteoglycans, glycoproteins, and glycosaminoglycans with a key role in maintaining endothelial cell homeostasis. Its functions include the regulation of endothelial barrier permeability and stability, the transduction of mechanical forces from the vascular lumen to the vessel walls ...
Cameron M, Mortazavi +3 more
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The endothelial glycocalyx and perioperative lung injury
Current Opinion in Anaesthesiology, 2017Ventilator-induced lung injury is a major contributor to perioperative lung injury. The end-expiratory lung volume, regional lung overdistension, and tidal recruitment are known to be the main factors causing subsequent alveolar damage and inflammation.
Florian, Brettner +2 more
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Clinical Hemorheology and Microcirculation
Background Sulodexide is a glycosaminoglycan-based drug prescribed to patients with angiopathy. We performed a pilot study to investigate whether sulodexide positively modulates the endothelial glycocalyx (EG) layer and the microcirculation in a porcine model of EG enzymatic damage.
David, Astapenko +14 more
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Background Sulodexide is a glycosaminoglycan-based drug prescribed to patients with angiopathy. We performed a pilot study to investigate whether sulodexide positively modulates the endothelial glycocalyx (EG) layer and the microcirculation in a porcine model of EG enzymatic damage.
David, Astapenko +14 more
openaire +3 more sources