Results 21 to 30 of about 571,172 (234)

Binding of Plasmodium falciparum to CD36 can be shielded by the glycocalyx [PDF]

Malaria Journal, 2017
Background Plasmodium falciparum-infected erythrocytes sequester in the microcirculation due to interaction between surface-expressed parasite proteins and endothelial receptors.
Casper Hempel, Christian William Wang, Jørgen Anders Lindholm Kurtzhals, Trine Staalsø   +3 more
doaj   +5 more sources

Update on the Role of the Endothelial Glycocalyx in Angiogenesis and Vascular Inflammation

Frontiers in Cell and Developmental Biology, 2021
The endothelial glycocalyx is a negatively charged, carbohydrate-rich structure that arises from the luminal surface of the vascular endothelium and is comprised of proteoglycans, glycoproteins, and glycolipids.
Zhengping Hu, Zhengping Hu, Issahy Cano, Issahy Cano, Patricia A. D’Amore, Patricia A. D’Amore, Patricia A. D’Amore   +6 more
doaj   +2 more sources

Engineering Mechanical Microenvironments: Integration of Substrate and Flow Mechanics Reveals the Impact on the Endothelial Glycocalyx. [PDF]

ACS Biomater Sci Eng
Hamrangsekachaee M, Chen Y, Tressler ER, McCauley L, O'Hare NR, Okorafor CC, Bencherif SA, Ebong EE.   +7 more
europepmc   +2 more sources

Evaluation of Endothelial Glycocalyx Damage in Neonatal Lambs With Diarrhoea: A Biomarker-Based Approach. [PDF]

Vet Med Sci
Neonatal lambs with diarrhoea showed increased nitric oxide and decreased heparan sulphate and angiopoietin‐2 levels, suggesting preserved endothelial glycocalyx integrity. Elevated ADAM15 levels in E. coli cases indicate a pathogen‐specific endothelial response, highlighting nitric oxide's potential protective role during inflammation.
Durgut MK, Ok M, Ider M, Tras B, Naseri A, Parlak TM, Alhallaq A, Iyigun SS.   +7 more
europepmc   +2 more sources

Endothelial glycocalyx degradation during sepsis: Causes and consequences

Matrix Biology Plus, 2021
The glycocalyx is a ubiquitous structure found on endothelial cells that extends into the vascular lumen. It is enriched in proteoglycans, which are proteins attached to the glycosaminoglycans heparan sulfate, chondroitin sulfate, dermatan sulfate ...
Ryan C. Sullivan, Matthew D. Rockstrom, Eric P. Schmidt, Joseph A. Hippensteel   +3 more
doaj   +1 more source

Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx

JCI Insight, 2023
The glomerular endothelial glycocalyx (GEnGlx) forms the first part of the glomerular filtration barrier. Previously, we showed that mineralocorticoid receptor (MR) activation caused GEnGlx damage and albuminuria.
Michael Crompton, J. Ferguson, R. Ramnath, K. L. Onions, A. S. Ogier, M. Gamez, C. Down, L. Skinner, K. Wong, L. Dixon, J. Sutak, S. Harper, P. Pontrelli, L. Gesualdo, H. Heerspink, R. Toto, G. Welsh, R. Foster, S. Satchell, M. Butler   +19 more
semanticscholar   +1 more source

Endothelial Glycocalyx in Retina, Hyperglycemia, and Diabetic Retinopathy.

American Journal of Physiology - Cell Physiology, 2023
The endothelial glycocalyx (EG) is a mesh-like network present on the apical surface of the endothelium. Membrane-bound proteoglycans, the major backbone molecules of the endothelial glycocalyx, consist of glycosaminoglycans attached to core proteins. In
G. Kaur, Norman R. Harris
semanticscholar   +1 more source

An IGFBP7hi endothelial cell subset drives T cell extravasation in psoriasis via endothelial glycocalyx degradation

Journal of Clinical Investigation, 2023
Dysfunction of vascular endothelial cells (ECs) facilitates imbalanced immune responses and tissue hyperinflammation. However, the heterogeneous functions of skin ECs and their underlying mechanism in dermatoses remain to be determined. Here, focusing on
Qingyang Li, S. Shao, Zhenlai Zhu, Jiaoling Chen, Junfeng Hao, Yaxing Bai, Bing Li, E. Dang, G. Wang   +8 more
semanticscholar   +1 more source

Glycocalyx Impairment in Vascular Disease: Focus on Inflammation

Frontiers in Cell and Developmental Biology, 2021
The glycocalyx is a complex polysaccharide-protein layer lining the lumen of vascular endothelial cells. Changes in the structure and function of the glycocalyx promote an inflammatory response in blood vessels and play an important role in the ...
Jing Qu, Yue Cheng, Wenchao Wu, Lixing Yuan, Xiaojing Liu, Xiaojing Liu   +5 more
doaj   +1 more source

Resuscitating the Endothelial Glycocalyx in Trauma and Hemorrhagic Shock

Annals of surgery open : perspectives of surgical history, education, and clinical approaches, 2023
The endothelium is lined by a protective mesh of proteins and carbohydrates called the endothelial glycocalyx (EG). This layer creates a negatively charged gel-like barrier between the vascular environment and the surface of the endothelial cell.
T. Anand, Angelica Alvarez Reyes, Michael C. Sjoquist, L. Magnotti, B. Joseph   +4 more
semanticscholar   +1 more source