Results 41 to 50 of about 27,105 (199)

The Role of Plasma Transfusion in Massive Bleeding: Protecting the Endothelial Glycocalyx?

Frontiers in Medicine, 2018
Massive hemorrhage is a leading cause of death worldwide. During the last decade several retrospective and some prospective clinical studies have suggested a beneficial effect of early plasma-based resuscitation on survival in trauma patients.
Stefano Barelli, Lorenzo Alberio, Lorenzo Alberio   +2 more
doaj   +1 more source

Inflammatory stimuli induce shedding of heparan sulfate from arterial but not venous porcine endothelial cells leading to differential proinflammatory and procoagulant responses

Scientific Reports, 2023
Endothelial dysfunction is an early event of vascular injury defined by a proinflammatory and procoagulant endothelial cell (EC) phenotype. Although endothelial glycocalyx disruption is associated with vascular damage, how various inflammatory stimuli ...
Anastasia Milusev, Alain Despont, Jane Shaw, Robert Rieben, Nicoletta Sorvillo   +4 more
doaj   +1 more source

Heparan sulfate mimetic fucoidan restores the endothelial glycocalyx and protects against dysfunction induced by serum of COVID-19 patients in the intensive care unit

ERJ Open Research, 2022
Accumulating evidence proves that endothelial dysfunction is involved in coronavirus disease 2019 (COVID-19) progression. We previously demonstrated that the endothelial surface glycocalyx has a critical role in maintenance of vascular integrity.
Lushun Yuan, Shuzhen Cheng, Wendy M.P.J. Sol, Anouk I.M. van der Velden, Hans Vink, Ton J. Rabelink, Bernard M. van den Berg   +6 more
doaj   +1 more source

Endothelial glycocalyx: Role in body fluid homeostasis and fluid management [PDF]

, 2019
Endothelial glycocalyx layer (EGL) coating the luminal surface of vascular endothelium plays an essential role in maintaining the normal fluid homeostasis of the body.
Goswami, Shreya, Kundra, Pankaj
core   +2 more sources

The glycocalyx as a permeability barrier: basic science and clinical evidence

Critical Care, 2022
Preclinical studies in animals and human clinical trials question whether the endothelial glycocalyx layer is a clinically important permeability barrier. Glycocalyx breakdown products in plasma mostly originate from 99.6–99.8% of the endothelial surface
Randal O. Dull, Robert G. Hahn
doaj   +1 more source

Phenotypic and functional characterization of corneal endothelial cells during in vitro expansion. [PDF]

, 2020
The advent of cell culture-based methods for the establishment and expansion of human corneal endothelial cells (CEnC) has provided a source of transplantable corneal endothelium, with a significant potential to challenge the one donor-one recipient ...
Aldave, Anthony J, Azimov, Rustam, Boere, Payton M, Chung, Doug D, Frausto, Ricardo F, George, Benjamin L, Hanser, E Maryam, Kao, Liyo, Kurtz, Ira, Mehta, Jodhbir S, Morselli, Marco, Peh, Gary SL, Pellegrini, Matteo, Swamy, Vinay S, Wu, Jessica   +14 more
core  

Studying the Endothelial Glycocalyx in vitro: What Is Missing?

Frontiers in Cardiovascular Medicine, 2021
All human cells are coated by a surface layer of proteoglycans, glycosaminoglycans (GAGs) and plasma proteins, called the glycocalyx. The glycocalyx transmits shear stress to the cytoskeleton of endothelial cells, maintains a selective permeability ...
Andrew B. Haymet, Andrew B. Haymet, Nicole Bartnikowski, Nicole Bartnikowski, Emily S. Wood, Emily S. Wood, Michael P. Vallely, Angela McBride, Angela McBride, Sophie Yacoub, Sophie Yacoub, Scott B. Biering, Eva Harris, Jacky Y. Suen, Jacky Y. Suen, John F. Fraser, John F. Fraser   +16 more
doaj   +1 more source

Sulodexide counteracts endothelial dysfunction induced by metabolic or non-metabolic stresses through activation of the autophagic program [PDF]

, 2019
OBJECTIVE: Endothelial dysfunction (ED) predisposes to venous thrombosis (VT) and post-thrombotic syndrome (PTS), a long-term VT-related complication. Sulodexide (SDX) is a highly purified glycosaminoglycan with antithrombotic, pro-fibrinolytic and anti ...
Angelucci, A., Antinozzi, C., Delle Monache, S., Fanzani, A., Felice, F. D. E., Festuccia, C., Gravina, G. L., Lessiani, G., Luigi, L. D. I., Maggio, R., Marampon, F., Mastroiacovo, D., Mattana, P., Megiorni, F., Pietrantonio, I., Tini, P., Tombolini, V.   +16 more
core   +1 more source

Endothelial Cell‐Specific Molecule‐1 (ESM1): An Endogenous Anticoagulant and Protective Factor in Venous Thrombosis

Advanced Science, EarlyView.
This study identifies ESM1 as an endogenous anticoagulant that modulates venous thrombosis. It shows that ESM1 deficiency triggers vascular occlusion in zebrafish and mice, whereas its restoration or overexpression prolongs clot‐formation time. Mechanistic analyses reveal that ESM1 activates HCII through its dermatan‐sulfate chain, uncovering a ...
Changsheng Chen, Xiaojuan Ge, Dongxu Fu, Haijun Mei, Feng Lv, Chao Yang, Jiahao Lu, Xiaozhong Shen, Bowen Li, Xiaoning Wang, Dong Liu   +10 more
wiley   +1 more source

Transport of spheres suspended in the fluid flowing between hexagonally arranged cylinders [PDF]

, 2006
The motion of a spherical particle suspended in an incompressible Newtonian fluid flowing longitudinally between hexagonally arranged circular cylinders has been numerically analysed by a finite-element method in the Stokes flow regime.
Sugihara-seki Masako, 関 眞佐子
core   +2 more sources