Biology of vascular endothelial growth factors [PDF]
Angiogenesis is the process by which new blood vessels are formed from existing vessels. The vascular endothelial growth factors (VEGFs) are considered as key molecules in the process of angiogenesis. The VEGF family currently includes VEGF‐A, ‐B, ‐C, ‐D, ‐E, ‐F and placenta growth factor (PlGF), that bind in a distinct pattern to three structurally ...
H. Roy, S. Bhardwaj, S. Ylä-Herttuala
semanticscholar +4 more sources
The biology of vascular endothelial growth factors. [PDF]
The discovery of the vascular endothelial growth factor (VEGF) family members VEGF, VEGF-B, placental growth factor (PlGF), VEGF-C and VEGF-D and their receptors VEGFR-1, -2 and -3 has provided tools for studying the vascular system in development as well as in diseases ranging from ischemic heart disease to cancer.
T. Tammela+3 more
semanticscholar +4 more sources
Vascular endothelial growth factors and vascular permeability [PDF]
Vascular endothelial growth factors (VEGFs) are key regulators of permeability. The principal evidence behind how they increase vascular permeability in vivo and in vitro and the consequences of that increase are addressed here.
D. Bates
semanticscholar +4 more sources
Comprehensive analysis of the oncogenic roles of vascular endothelial growth factors and their receptors in stomach adenocarcinoma [PDF]
Background: Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) play complicated oncogenic roles in multiple tumors by initiating and promoting tumor angiogenesis and lymphangiogenesis.
Jianxin Li, Ting Han
doaj +2 more sources
Growth factors are released by mechanically wounded endothelial cells. [PDF]
Growth factors may be required at sites of mechanical injury and normal wear and tear in vivo, suggesting that the direct action of mechanical forces on cells could lead to growth factor release. Scraping of cells from the tissue culture substratum at 37
Paul L. McNeil+3 more
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Vascular Endothelial Growth Factor Induces Endothelial Fenestrations In Vitro [PDF]
Abstract. Vascular endothelial growth factor (VEGF) is an important regulator of vasculogenesis, angiogenesis, and vascular permeability. In contrast to its transient expression during the formation of new blood vessels, VEGF and its receptors are continuously and highly expressed in some adult tissues, such as the kidney glomerulus and choroid plexus.
Sybille Esser+5 more
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Differential Regulation of Vascular Endothelial Growth Factors by Promoter-targeted shRNAs [PDF]
Vascular endothelial growth factors (VEGFs) and their receptors (VEGF-R) are central regulators of vasculogenesis, angiogenesis, and lymphangiogenesis.
Nihay Laham-Karam+3 more
doaj +2 more sources
Vascular endothelial growth factors (VEGFs) and stroke [PDF]
D. Greenberg, K. Jin
semanticscholar +2 more sources
Vascular endothelial growth factor B, a novel growth factor for endothelial cells. [PDF]
We have isolated and characterized a novel growth factor for endothelial cells, vascular endothelial growth factor B (VEGF-B), with structural similarities to vascular endothelial growth factor (VEGF) and placenta growth factor. VEGF-B was particularly abundant in heart and skeletal muscle and was coexpressed with VEGF in these and other tissues.
Vladimir Joukov+9 more
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Vascular Endothelial Growth Factor [PDF]
Vascular endothelial growth factor (VEGF, VEGF-A) is a major regulator of physiological and pathological angiogenesis. Several VEGF inhibitors have been approved by the FDA for the treatment of advanced cancer and neovascular age-related macular degeneration.
openaire +8 more sources