Results 61 to 70 of about 746,723 (389)

Endothelial progenitor cells in cardiovascular diseases

Aging Medicine, 2018
Cardiovascular diseases (CVDs) are the leading cause of death in both developed and developing countries. Endothelial progenitor cells (EPCs) are derived from hematopoietic stem cells with powerful function of angiogenesis.
Yumin Qiu, Chanjuan Zhang, Gaoxing Zhang, J. Tao   +3 more
semanticscholar   +1 more source

The Effects of HMG-CoA Reductase Inhibitor on Vascular Progenitor Cells

Journal of Pharmacological Sciences, 2006
.: Circulating bone marrow-derived vascular progenitor cells contribute to angiogenesis, atherosclerosis, and the response to vascular injury. These vascular progenitor cells consist of two cell groups, endothelial progenitor cells (EPCs) and smooth ...
Kusuyama Takanori, Omura Takashi, Nishiya Daisuke, Enomoto Soichiro, Matsumoto Ryo, Murata Takashi, Takeuchi Kazuhide, Yoshikawa Junichi, Yoshiyama Minoru   +8 more
doaj   +1 more source

Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction - (TOPCARE-AMI) [PDF]

, 2002
Background - Experimental studies suggest that transplantation of blood-derived or bone marrow–derived progenitor cells beneficially affects postinfarction remodeling.
Aicher, A, Assmus, B, Britten, M, Dimmeler, S, Döbert, N, Grünwald, F, Hoelzer, D, Lehmann, R, Martin, H, Schächinger, V, Teupe, C, Urbich, C, Zeiher, AM   +12 more
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Mouse lung contains endothelial progenitors with high capacity to form blood and lymphatic vessels

BMC Cell Biology, 2010
Background Postnatal endothelial progenitor cells (EPCs) have been successfully isolated from whole bone marrow, blood and the walls of conduit vessels. They can, therefore, be classified into circulating and resident progenitor cells.
Barleon Bernhard, Badar Muhammad, Norgall Susanne, Städtler Anna-Maria, Richter Georg, Buttler Kerstin, Rennecke Moritz, Schniedermann Judith, May Tobias, Wilting Jörg, Weich Herbert A   +10 more
doaj   +1 more source

Arteriogenesis versus angiogenesis: similarities and differences [PDF]

, 2007
Cardiovascular diseases account for more than half of total mortality before the age of 75 in industrialized countries. To develop therapies promoting the compensatory growth of blood vessels could be superior to palliative surgical surgical ...
Eitenmüller, Inka, Heil, Matthias, Schaper, Wolfgang, Schmitz-Rixen, Thomas   +3 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Concise Review: Endothelial Progenitor Cells in Regenerative Medicine: Applications and Challenges

Stem Cells Translational Medicine, 2016
Endothelial progenitor cells (EPCs) are currently being studied as candidate cell sources for revascularization strategies. Significant advances have been made in understanding the biology of EPCs, and preclinical studies have demonstrated the ...
M. Chong, W. Ng, J. Chan
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Single-Cell Transcriptional Profiling of Aortic Endothelium Identifies a Hierarchy from Endovascular Progenitors to Differentiated Cells

Cell Reports, 2019
Summary: The cellular and molecular profiles that govern the endothelial heterogeneity of the circulatory system have yet to be elucidated. Using a data-driven approach to study the endothelial compartment via single-cell RNA sequencing, we characterized
Samuel W. Lukowski, Jatin Patel, Stacey B. Andersen, Seen-Ling Sim, Ho Yi Wong, Joshua Tay, Ingrid Winkler, Joseph E. Powell, Kiarash Khosrotehrani   +8 more
doaj   +1 more source