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Endothelial Differentiation of Embryonic Stem Cells [PDF]

Current Protocols in Stem Cell Biology, 2008
AbstractVascular progenitor cells derived from stem cells could potentially lead to a variety of clinically relevant applications, including cell‐based therapies and tissue engineering. Here, we describe methods for isolating purified proliferating populations of vascular endothelial cells from mouse embryonic stem cells (mESC) using Flk‐1 positive ...
Kara E. McCloskey, Nicholas E. Lauer, Alicia A. Blancas   +2 more
openaire   +3 more sources

Current concepts on endothelial stem cells definition, location, and markers

Stem Cells Translational Medicine, 2021
Ischemic vascular disease is a major cause of mortality and morbidity worldwide, and regeneration of blood vessels in perfusion‐deficient tissues is a worthwhile therapeutic goal. The idea of delivering endothelial stem/progenitor cells to repair damaged
Sarah E.J. Chambers, Varun Pathak, Edoardo Pedrini, Lou Soret, Nicolas Gendron, Coralie L. Guerin, Alan W. Stitt, David M. Smadja, Reinhold J. Medina   +8 more
doaj   +1 more source

Discovering the Potential of Dental Pulp Stem Cells for Corneal Endothelial Cell Production: A Proof of Concept

Frontiers in Bioengineering and Biotechnology, 2021
Failure of corneal endothelium cell monolayer is the main cause leading to corneal transplantation. Autologous cell-based therapies are required to reconstruct in vitro the cell monolayer.
Begoña M. Bosch, Enrique Salero, Raquel Núñez-Toldrà, Alfonso L. Sabater, F. J. Gil, Roman A. Perez   +5 more
doaj   +1 more source

Placental growth factor expression is required for bone marrow endothelial cell support of primitive murine hematopoietic cells. [PDF]

PLoS ONE, 2013
Two distinct microenvironmental niches that regulate hematopoietic stem/progenitor cell physiology in the adult bone marrow have been proposed; the endosteal and the vascular niche.
Xiaoying Zhou, Lora W Barsky, Gregor B Adams   +2 more
doaj   +1 more source

A Novel Molecular and Functional Stemness Signature Assessing Human Cord Blood-Derived Endothelial Progenitor Cell Immaturity. [PDF]

PLoS ONE, 2016
Endothelial Colony Forming Cells (ECFCs), a distinct population of Endothelial Progenitor Cells (EPCs) progeny, display phenotypic and functional characteristics of endothelial cells while retaining features of stem/progenitor cells.
Oriane Guillevic, Ségolène Ferratge, Juliette Pascaud, Catherine Driancourt, Julie Boyer-Di-Ponio, Georges Uzan   +5 more
doaj   +1 more source

Co-growth of Stem Cells With Target Tissue Culture as an Easy and Effective Method of Directed Differentiation

Frontiers in Bioengineering and Biotechnology, 2021
The long-term co-culture of mouse embryonic stem cells (mESC) with rat endothelial cells (EC) was tested for contact differentiation into the endothelial lineage.
Marina Valentinovna Kovina, Marina Valentinovna Kovina, Marina Valentinovna Kovina, Tatyana Gennadievna Dyuzheva, Mikhail Evgenievich Krasheninnikov, Sergey Alexandrovich Yakovenko, Sergey Alexandrovich Yakovenko, Yury Mikhailovich Khodarovich   +7 more
doaj   +1 more source

An updated view on the differentiation of stem cells into endothelial cells [PDF]

Science China Life Sciences, 2014
Endothelial cells form the internal barrier between circulating blood and the vessel wall. They regulate arterial activity and mediate pathological reactions to vascular injuries such as atherosclerosis and balloon angioplasty. The development and differentiation of endothelial cells is a complex and coordinated process involving multiple levels of ...
Feng Yang, Yutao Wu, Jianhua Zhu, Ting Chen, Yijiang Zhou, Li Zhang, Mei Yang   +6 more
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Gap Junction–Mediated Transport of Metabolites Between Stem Cells and Vascular Endothelial Cells

Cell Transplantation, 2022
We have previously demonstrated that small molecular transfer, such as glucose, between hematopoietic stem cells (HSCs) or mesenchymal stem cells (MSCs) and vascular endothelial cells via gap junctions constitutes an important mechanism of stem cell ...
Yuko Ogawa, Rie Akamatsu, Akihiro Fuchizaki, Kazuta Yasui, Orie Saino, Mitsunobu Tanaka, Akie Kikuchi-Taura, Takafumi Kimura, Akihiko Taguchi   +8 more
doaj   +1 more source

Endothelial and perivascular cells maintain haematopoietic stem cells [PDF]

Nature, 2012
Several cell types have been proposed to create niches for haematopoietic stem cells (HSCs). However, the expression patterns of HSC maintenance factors have not been systematically studied and no such factor has been conditionally deleted from any candidate niche cell. Thus, the cellular sources of these factors are undetermined. Stem cell factor (SCF;
Sean J. Morrison, Grigori Enikolopov, Thomas L. Saunders, Lei Ding   +3 more
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Application of vascular endothelial cells in stem cell medicine

World Journal of Clinical Cases, 2021
Stem cell medicine is gaining momentum in the development of therapy for various end-stage diseases. The search for new seed cells and exploration of their application prospects are topics of interest in stem cell medicine. In recent years, vascular endothelial cells (VECs) have attracted wide attention from scholars.
Liang, Qing-Qing, Liu, Lei
openaire   +2 more sources