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Endothelins and liver cirrhosis

open access: diamondPortal Hypertension & Cirrhosis, 2022
Endothelins are a family of 21‐amino acid oligopeptides, called endothelin‐1 (ET‐1), endothelin‐2 (ET‐2), and endothelin 3 (ET‐3). Endothelins act on hepatocytes, liver endothelial cells, and Kupffer cells in a paracrine or autocrine manner through two G
Necati Örmeci
doaj   +2 more sources

Anti-Graying Effects of External and Internal Treatments with Luteolin on Hair in Model Mice [PDF]

open access: yesAntioxidants
Little is known about the anti-graying effects of antioxidants on hair. The anti-graying effects of three antioxidants (luteolin, hesperetin, and diosmetin) on hair were investigated according to the sequential processes of hair graying that were ...
Machiko Iida   +7 more
doaj   +2 more sources

Vasoplegia: A Review [PDF]

open access: yesMethodist DeBakey Cardiovascular Journal, 2023
Vasoplegia is a condition characterized by persistent low systemic vascular resistance despite a normal or high cardiac index, resulting in profound and uncontrolled vasodilation. Vasoplegia may occur due to various conditions, including cardiac failure,
Iqbal Ratnani   +3 more
doaj   +2 more sources

Role of Vasoactive Hormone-Induced Signal Transduction in Cardiac Hypertrophy and Heart Failure [PDF]

open access: yesCells
Heart failure is the common concluding pathway for a majority of cardiovascular diseases and is associated with cardiac dysfunction. Since heart failure is invariably preceded by adaptive or maladaptive cardiac hypertrophy, several biochemical mechanisms
Naranjan S. Dhalla   +5 more
doaj   +2 more sources

The endothelin receptor antagonist macitentan ameliorates endothelin-mediated vasoconstriction and promotes the survival of retinal ganglion cells in rats

open access: yesFrontiers in Ophthalmology, 2023
Glaucoma is a chronic and progressive eye disease, commonly associated with elevated intraocular pressure (IOP) and characterized by optic nerve degeneration, cupping of the optic disc, and loss of retinal ganglion cells (RGCs).
Bindu Kodati   +18 more
doaj   +1 more source

Miniaturized peptidomimetics and nano-vesiculation in endothelin types through probable nano-disk formation and structure property relationships of endothelins’ fragments

open access: yesNanotechnology Reviews, 2021
The present study deals with the molecular modeling studies of the endothelins (ETs), a multi-functional 21 amino acid (AA) peptides, with sub-types ET-I, II, and III to find the structure property relationship (SPR) of different fragments naturally ...
Khan Riaz A., Khan Azra J.
doaj   +1 more source

Endothelins as mediators in the modulation of cardiac performance [PDF]

open access: yesPraxis Medica, 2014
The role of endothelin in cardiovascular physiology and pathophysiology has been undeniable ever since its discovery. Endothelins in the heart are important for the development, growth and remodeling, as well as for the control of contractility and ...
Smiljić Sonja   +4 more
doaj   +1 more source

The Role of Endothelins, IL-18, and NGAL in Kidney Hypothermic Machine Perfusion

open access: yesBiomedicines, 2021
Ischemia-reperfusion injury (IRI) occurring after renal transplantation is a complex biochemical process that can be monitored by specific biomarkers. The roles of those are not yet fully elucidated.
Karol Tejchman   +7 more
doaj   +1 more source

Endothelins and Sarafotoxins: Peptides of Similar Structure and Different Function

open access: yesActa Medica, 2004
Endothelins are endogenous vasoactive peptides that are considered among the most potent vasoconstrictor substances known. In addition to their vascular effects, endothelins and their receptors have been shown to be present in many organs and share ...
Jiří Patočka   +3 more
doaj   +1 more source

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