Results 1 to 10 of about 36,666 (331)
The endothelin receptor antagonist macitentan ameliorates endothelin-mediated vasoconstriction and promotes the survival of retinal ganglion cells in rats [PDF]
Frontiers in Ophthalmology, 2023 Glaucoma is a chronic and progressive eye disease, commonly associated with elevated intraocular pressure (IOP) and characterized by optic nerve degeneration, cupping of the optic disc, and loss of retinal ganglion cells (RGCs).
Bindu Kodati +18 more
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Anti-Graying Effects of External and Internal Treatments with Luteolin on Hair in Model Mice [PDF]
AntioxidantsLittle is known about the anti-graying effects of antioxidants on hair. The anti-graying effects of three antioxidants (luteolin, hesperetin, and diosmetin) on hair were investigated according to the sequential processes of hair graying that were ...
Machiko Iida +7 more
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Methodist DeBakey Cardiovascular Journal, 2023 Vasoplegia is a condition characterized by persistent low systemic vascular resistance despite a normal or high cardiac index, resulting in profound and uncontrolled vasodilation. Vasoplegia may occur due to various conditions, including cardiac failure,
Iqbal Ratnani +3 more
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Cryo-EM structure of the endothelin-1-ETB-Gi complex [PDF]
eLife, 2023 The endothelin ETB receptor is a promiscuous G-protein coupled receptor that is activated by vasoactive peptide endothelins. ETB signaling induces reactive astrocytes in the brain and vasorelaxation in vascular smooth muscle.
Fumiya K Sano +3 more
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Role of Vasoactive Hormone-Induced Signal Transduction in Cardiac Hypertrophy and Heart Failure [PDF]
CellsHeart failure is the common concluding pathway for a majority of cardiovascular diseases and is associated with cardiac dysfunction. Since heart failure is invariably preceded by adaptive or maladaptive cardiac hypertrophy, several biochemical mechanisms
Naranjan S. Dhalla +5 more
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The Potential Anti-remodeling Effect of Paroxetine After Myocardial Infarction May Be Blunted by Beta-Blockers [PDF]
Frontiers in Cardiovascular Medicine, 2022 BackgroundLeft ventricular (LV) remodeling consists in maladaptive changes in cardiac geometry and function following an insult such as ST-segment elevation myocardial infarction (STEMI).
Oriol Iborra-Egea +15 more
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Structural basis of antagonist selectivity in endothelin receptors [PDF]
Cell DiscoveryEndothelins and their receptors, ETA and ETB, play vital roles in maintaining vascular homeostasis. Therapeutically targeting endothelin receptors, particularly through ETA antagonists, has shown efficacy in treating pulmonary arterial hypertension (PAH)
Junyi Hou +15 more
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Endothelins and liver cirrhosis
Portal Hypertension & Cirrhosis, 2022 Endothelins are a family of 21‐amino acid oligopeptides, called endothelin‐1 (ET‐1), endothelin‐2 (ET‐2), and endothelin 3 (ET‐3). Endothelins act on hepatocytes, liver endothelial cells, and Kupffer cells in a paracrine or autocrine manner through two G
Necati Örmeci
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Nanotechnology Reviews, 2021 The present study deals with the molecular modeling studies of the endothelins (ETs), a multi-functional 21 amino acid (AA) peptides, with sub-types ET-I, II, and III to find the structure property relationship (SPR) of different fragments naturally ...
Khan Riaz A., Khan Azra J.
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Endothelins as mediators in the modulation of cardiac performance [PDF]
Praxis Medica, 2014 The role of endothelin in cardiovascular physiology and pathophysiology has been undeniable ever since its discovery. Endothelins in the heart are important for the development, growth and remodeling, as well as for the control of contractility and ...
Smiljić Sonja +4 more
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