Results 81 to 90 of about 37,353 (347)
Elucidating essential kinases of endothelin signalling by logic modelling of phosphoproteomics data
Molecular Systems Biology, 2019 Endothelins (EDN) are peptide hormones that activate a GPCR signalling system and contribute to several diseases, including hypertension and cancer. Current knowledge about EDN signalling is fragmentary, and no systems level understanding is available ...
Alexander Schäfer +8 more
doaj +1 more source
Factors influencing splanchnic microcirculation in animal models of endotoxaemia [PDF]
, 2011 Even though severe sepsis and septic shock therapy has improved in recent years, mortality remains high (22-50%). Disturbances in splanchnic organ homeostasis and increases in gut permeability have long been presumed to contribute to systemic ...
Andersson, Andreas
core +1 more source
Developmental Dynamics, EarlyView.Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley +1 more source
Regulation of Cerebral Blood Flow
International Journal of Vascular Medicine, 2011 The control of cerebral blood flow is complex, and only beginning to be elucidated. Studies have identified three key regulatory paradigms. The first is cerebral pressure autoregulation, which maintains a constant flow in the face of changing cerebral ...
Eric C. Peterson +2 more
doaj +1 more source
Measurement of plasma endothelin-1 in experimental hypertension and in healthy subjects [PDF]
, 2017 Background: Endothelin-1 is an endothelium-derived potent vasoconstrictor peptide of 21 amino acids. To establish reference values in different models of hypertension and in human subjects an assay for plasma immunoreactive endothelin-1 (ET-1) was ...
Abdel-Sayed, Saad +5 more
core
Effects of antihypertensive treatment on endothelial function in postmenopausal hypertensive women. A significant role for aldosterone inhibition [PDF]
, 2011 Introduction: Endothelial dysfunction is a well-demonstrated independent predictor of cardiovascular events in hypertensive postmenopausal women. Accordingly, it is plausible that improving endothelial function could represent an adjunctive target for ...
Iaccarino, Daniele +6 more
core +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Role of the Angiogenic Factors in Cholangiocarcinoma
Applied Sciences, 2019 Angiogenesis plays a fundamental role in tumor growth and progression. It is regulated by several growth factors, including vascular endothelial growth factor protein family (VEGF) and its receptors, which are probably the most important factors ...
Romina Mancinelli +5 more
doaj +1 more source
Darusentan, a selective endothelin A receptor antagonist, for the oral treatment of resistant hypertension [PDF]
, 2010 Resistant hypertension is defined as failure to lower blood pressure to target when a patient adheres to the maximum tolerated doses of three antihypertensive drugs including a diuretic.
Enseleit, F +2 more
core +1 more source