Results 61 to 70 of about 3,916 (146)

Efficacy and safety of iloprost in trauma patients with haemorrhagic shock-induced endotheliopathy-Protocol for the multicentre randomized, placebo-controlled, blinded, investigator-initiated shine-trauma trial [PDF]

, 2021
Background: Traumatic injury accounts for 800 000 deaths in the European Union annually. The main causes of deaths in trauma patients are exsanguination and multiple organ failure (MOF).
Lange, Theis, Hanne Hee Henriksen, Nielsen, Christian, Christian Nielsen, Theis Lange, Hans Kirkegaard, Naess, Pal Aksel, Jakob Stensballe, Schmal, Hagen, Johansson, Par I., Christine Gaarder, Bovbjerg, Pernille, Pall, Marlene, Pål Aksel Næss, Næss, Pål Aksel, Kirkegaard, Hans, Hagen Schmal, Gaarder, Christine, Marlene Pall, Henriksen, Hanne Hee, Pernille Bovbjerg, Pär I. Johansson, Stensballe, Jakob, Eriksen, Christian Fenger, Christian Fenger Eriksen   +24 more
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Inflammatory Stewardship—A Perspective for Active Management of Acute Inflammation

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Inflammatory stewardship frames inflammation as a manageable clinical domain requiring explicit strategy, governance, and feedback. It aligns diagnostics, risk stratification, biomarker interpretation, and immunomodulatory decisions across perioperative and critical‐care teams.
Lennart Finn Herrlich, Hubert Schrezenmeier, David Alexander Christian Messerer   +2 more
wiley   +1 more source

CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac syndrome [PDF]

, 2019
International audienceNeuroinflammation is often associated with blood-brain-barrier dysfunction, which contributes to neurological tissue damage. Here, we reveal the pathophysiology of Susac syndrome (SuS), an enigmatic neuroinflammatory disease with ...
Dornmair, K., Sven G. Meuth, Markus Schwaninger, Kuhlmann, T., Beltrán, Eduardo, Wolfgang Brück, Pawlitzki, M., Schwaninger, M., Laplaud, D.A., Liblau, R., Meuth, Sven, G, Romana Höftberger, Schneider-Hohendorf, Tilman, Höftberger, R., Andreas Schulte-Mecklenbeck, Kleffner, Ilka, Meyer, C., Michael Barnett, Hans Lassmann, Nicholas Schwab, John Parratt, Reddel, Stephen, Brueck, Wolfgang, Wildemann, B., Pawlitzki, Marc, Ringelstein, Marius, Schwab, N., Gross, C.C., Parratt, J., Lassmann, Hans, Tröscher, Anna, Ilka Kleffner, Markus Kraemer, Herich, Sebastian, David-Axel Laplaud, Tilman Schneider-Hohendorf, Dörr, Jan, Höftberger, Romana, Hardy, Todd A., Loussouarn, D., Gross, Catharina, Kleffner, I., Sebastian Herich, Tröscher, A.R., Bauer, Jan, Martin-Blondel, G., Lidia Yshii, Plate, H., Yshii, L., Buckland, Michael E., Brück, W., Roland Liblau, Heinz Wiendl, Reddel, Stephen W., Lassmann, H., Klotz, L., Marius Ringelstein, Hardy, Todd, Dörr, J., Gross, Catharina C., Stephen W. Reddel, Luisa Klotz, Meyer, Céline, Michael E. Buckland, Meuth, S.G., Ringelstein, M., Meuth, Sven G., Schneider-Hohendorf, T., Jan Dörr, Martin-Blondel, Guillaume, Schulte-Mecklenbeck, A., Brigitte Wildemann, Loussouarn, Delphine, Barnett, M., Parratt, John, Laplaud, David-Axel, Reddel, S.W., Bhatia, U., Tanja Kuhlmann, Eduardo Beltrán, Klaus Dornmair, Buckland, M.E., Barnett, Michael, Herich, S., Kraemer, M., Yshii, Lidia, Liblau, Roland, Schwab, Nicholas, Delphine Loussouarn, Henrike Plate, Wiendl, Heinz, Schwaninger, Markus, Troscher, Anna R., Todd A. Hardy, Catharina C. Gross, Wildemann, Brigitte, Bhatia, Urvashi, Bruck, Wolfgang, Jan Bauer, Kraemer, Markus, Buckland, Michael, Kuhlmann, Tanja, Wiendl, H., Hardy, T.A., Schulte-Mecklenbeck, Andreas, Céline Meyer, Plate, Henrike, Bauer, J., Beltrán, E., Lassmann, Hans, P, Klotz, Luisa, Doerr, Jan, Dornmair, Klaus, Marc Pawlitzki, Krämer, Markus, Hoeftberger, Romana, Anna R. Tröscher, Guillaume Martin-Blondel, Urvashi Bhatia   +118 more
core   +1 more source

Opposing Association of Lung Neutrophils and PD‐L1+ Monocytes in Age‐Related Severity of SARS‐CoV‐2 Infection

Aging Cell, Volume 25, Issue 6, June 2026.
Aging skews pulmonary myeloid responses during acute SARS‐CoV‐2 infection toward severe disease. Disease progression is characterized by excessive lung neutrophil accumulation together with impaired activation of classical monocytes, including a defect in PD‐L1 upregulation.
Serban Morosan, Clémence Granier, Noëlline Guillou, Selma Bennacer, Eléonore Weber‐Delacroix, Julianne Peronnet, François Lanthiez, Sandrine Barthelemy, Christelle Enond, Jean‐Luc Diehl, Elena Paillaud, Carine El‐Sissy, Anne‐Geneviève Marcelin, Vincent Calvez, Stéphane Marot, Amélie Guihot, Christophe Parizot, Karim Dorgham, Guy Gorochov, Christophe Combadière, Alexandre Boissonnas   +20 more
wiley   +1 more source

Endothelial Glycocalyx, Mucin, and Glycan: A Hierarchical Synthesis From Molecular Building Blocks to Supramolecular Functional Barriers

Microcirculation, Volume 33, Issue 4, May 2026.
ABSTRACT Glycans encode molecular information, but the endothelial glycocalyx is an organized, multicomponent supramolecular structure whose architecture integrates glycan cues into coherent vascular responses in vivo. The vascular endothelial glycocalyx (eGCX) is a flow‐conditioned, membrane‐coupled surface layer that mediates mechanotransduction ...
Hiroyuki Tomita, Akio Suzuki, Hideshi Okada   +2 more
wiley   +1 more source

Platelet releasates mitigate the endotheliopathy of trauma. [PDF]

BACKGROUND: Platelets are well known for their roles in hemostasis, but they also play a key role in thromboinflammatory pathways by regulating endothelial health, stimulating angiogenesis, and mediating host defense through both contact dependent and ...
LaCroix, Ian, Kornblith, Lucy, Erickson, Christopher, Thielen, Otto, DAlessandro, Angelo, Stocker, Benjamin, Herrera-Rodriguez, Kimberly, Hallas, William, Gallagher, Lauren, Nunez-Garcia, Brenda, Argabright, Amy, Silliman, Christopher, Cohen, Mitchell, Mitra, Sanchayita, Ramser, Benjamin, Fields, Alexander, Chou, Yu   +16 more
core   +1 more source

Endotheliopathy is associated with slower liberation from mechanical ventilation:a cohort study

, 2022
Background: Endotheliopathy is suggested as pivotal pathophysiology of sepsis and trauma-associated organ failure, but its role in acute respiratory failure is not yet determined.
Larsson, Johan E., Johansson, Pär I., Lindegaard, Birgitte, Schønemann-Lund, Martin, Bestle, Morten H., Itenov, Theis S.   +5 more
core   +1 more source

Endothelial thrombomodulin—Its role in trauma‐induced coagulopathy

Transfusion, Volume 66, Issue S1, Page S246-S256, May 2026.
Abstract Background Trauma‐induced coagulopathy (TIC) describes a complex set of coagulation changes affecting severely injured patients. The thrombomodulin‐protein C axis is central to the evolution of TIC. Soluble thrombomodulin (sTM) levels are elevated after injury and predict poor clinical outcomes.
Jeries Abu‐Hanna, Gael B. Morrow, Gang Xu, Lewis Timms, Naveed Akbar, Michael Laffan, Robin P. Choudhury, Nicola Curry   +7 more
wiley   +1 more source

Molecular pathogenesis of STEC-HUS caused byendothelial heterogeneity and unprotected complementactivation, leading to endotheliopathy and impairedADAMTS13 activity: based on two-activation theory ofthe endothelium and vascular microthrombotic disease [PDF]

, 2017
Shiga toxin-producing E. coli hemolytic-uremic syndrome (STEC-HUS) is characterized by acute renal failure associated with thrombocytopenia and mciroangiopathic hemolytic anemia following exposure to STEC.
Chang, Jae C
core   +1 more source

Additional file 1 of Resuscitation-associated endotheliopathy (RAsE): a conceptual framework based on a systematic review and meta-analysis

, 2023
Additional file 1: Supplementary figures: S1. Funnel plots. S2. Galbraith plots. S3. Shock pathophysiology. Supplementary tables: S1. Search terms. S2.All studies meeting the inclusion criteria. S3. Risk of bias assessment.
Sainath Raman (5478764), Kathryn Maitland (21356), Gianluigi Li Bassi (8889608), Declan P. Sela (17429340), John F. Fraser (5321111), Bailey Schneider (17429346), Reema Rachakonda (17429343), Jacky Y. Suen (360130), Louise E. See Hoe (17429349), Jonathon P. Fanning (5321105), Nchafatso G. Obonyo (17429337)   +10 more
core   +1 more source