Results 71 to 80 of about 3,316 (159)

Platelet releasates mitigate the endotheliopathy of trauma

Journal of Trauma and Acute Care Surgery
BACKGROUND Platelets are well known for their roles in hemostasis, but they also play a key role in thromboinflammatory pathways by regulating endothelial health, stimulating angiogenesis, and mediating host defense through both contact dependent and independent signaling.
Gallagher, Lauren, LaCroix, Ian, Fields, Alexander, Mitra, Sanchayita, Argabright, Amy, DAlessandro, Angelo, Erickson, Christopher, Nunez-Garcia, Brenda, Herrera-Rodriguez, Kimberly, Chou, Yu, Stocker, Benjamin, Ramser, Benjamin, Thielen, Otto, Hallas, William, Silliman, Christopher, Kornblith, Lucy, Cohen, Mitchell   +16 more
openaire   +4 more sources

Management of neonatal massive hemorrhage: A narrative review

Transfusion, Volume 66, Issue 5, Page 1012-1022, May 2026.
Cheryl S. L. Chooi, Mary Claire Simmonds, Laura Fisher, Tara Crawford, Michael J. Stark, Scott Morris, Marcus Brecht, Fiona Taverner   +7 more
wiley   +1 more source

Vascular Alterations Following COVID-19 Infection: A Comprehensive Literature Review

Life
SARS-CoV-2, the causative agent of the ongoing COVID-19 pandemic, has revealed a broader impact beyond the respiratory system, predominantly affecting the vascular system with various adverse manifestations.
Paschalis Karakasis, Athina Nasoufidou, Marios Sagris, Nikolaos Fragakis, Konstantinos Tsioufis   +4 more
doaj   +1 more source

Sinusoidal endotheliopathy in nonalcoholic steatohepatitis: therapeutic implications

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2021
Liver sinusoidal endothelial cells (LSECs) are distinct subtypes of endothelial cells lining a low flow vascular bed at the interface of the liver parenchyma and the circulating immune cells and soluble factors. Emerging literature implicates LSEC in the pathogenesis and progression of nonalcoholic fatty liver disease (NAFLD).
openaire   +3 more sources

Surgical hemorrhagic complications in COVID-19 patients: risk factors and development mechanisms

Журнал инфектологии
A trigger mechanism plays a leading role in the pathogenesis of hemorrhagic syndrome in COVID-19. On one hand; the development of heparin-induced coagulopathy is not excluded; on the other hand; the development of critical conditions is accompanied by ...
K. V. Medvedev, D. A. Gusev, V. A. Zinserling, M. A. Protchenkov, N. Yu. Semenova, V. S. Evstropov   +5 more
doaj   +1 more source

Endotheliopathy of Obesity [PDF]

Circulation, 2020
openaire   +2 more sources

Extracellular vesicles as key biomarkers in COVID-19: insights into disease severity and mortality through CD86 and other immune markers

Frontiers in Immunology
This study explores the concentration, size, and epitope profiles of extracellular vesicles (EVs) as biomarkers for COVID-19 outcomes. CD86 stood out as a key predictor of mortality, suggesting that EV profiling could help assess disease severity and ...
Lou Soret, Lou Soret, Coralie L. Guerin, Coralie L. Guerin, Joseph Roux de Bezieux, Katharine Rus, Léa Guyonnet, Georges Abi Abdallah, Georges Abi Abdallah, Nicolas Gendron, Nicolas Gendron, Anne Godier, Anne Godier, Diane Zlotnik, Diane Zlotnik, Alexandre G. Lellouch, Alexandre G. Lellouch, Alexandre G. Lellouch, Annick Viguier, Jean-Luc Diehl, Jean-Luc Diehl, Pascale Gaussem, Pascale Gaussem, Aurélien Philippe, Aurélien Philippe, David M. Smadja, David M. Smadja   +26 more
doaj   +1 more source

Soluble Thrombomodulin Links Viremia and Mortality During COVID‐19: Results From the ACTIV‐4a Trial

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background COVID‐19 and other respiratory viral infections can cause cardiovascular complications. SARS‐CoV‐2 virions are found in the blood, and circulating viral RNA levels are associated with death.
Benjamin E. Zuchelkowski, Kyle W. Inman, S. Mehdi Nouraie, Neeharika Beru, Asma Naqvi, Shulin Qin, Calvin H. Yeh, Yingze Zhang, Faraaz A. Shah, Lokesh Sharma, Charles S. Dela Cruz, Lianghui Zhang, Bryan J. McVerry, Alison Morris, Matthew D. Neal, Jansen Seheult, Georgios D. Kitsios, John W. Mellors, Daniel A. Lawrence, Paul Y. Kim, Jana L. Jacobs, William G. Bain   +21 more
doaj   +1 more source

Trauma promotes heparan sulfate modifications and cleavage that disrupt homeostatic gene expression in microvascular endothelial cells

Frontiers in Cell and Developmental Biology
Introduction: Heparan sulfate (HS) in the vascular endothelial glycocalyx (eGC) is a critical regulator of blood vessel homeostasis. Trauma results in HS shedding from the eGC, but the impact of trauma on HS structural modifications that could influence ...
Robert P. Richter, Robert P. Richter, James D. Odum, Camilla Margaroli, Jessica C. Cardenas, Lei Zheng, Kaushlendra Tripathi, Zhangjie Wang, Katelyn Arnold, Ralph D. Sanderson, Jian Liu, Jillian R. Richter, Jillian R. Richter   +12 more
doaj   +1 more source

SARS-CoV-2 and the spike protein in endotheliopathy

Trends in Microbiology
SARS-CoV-2, the causative agent of COVID-19, primarily affects the epithelial compartment in the upper and lower airways. There is evidence that the microvasculature in both the pulmonary and extrapulmonary systems is a major target of SARS-CoV-2. Consistent with this, vascular dysfunction and thrombosis are the most severe complications in COVID-19 ...
Luca Perico, Ariela Benigni, Giuseppe Remuzzi   +2 more
openaire   +2 more sources