Results 51 to 60 of about 3,916 (146)

From the lethal triad to the lethal diamond and beyond: An AI‐augmented perspective on modern hemostatic resuscitation

Hong Kong Journal of Emergency Medicine, Volume 33, Issue 5, October 2026.
Abstract Background Uncontrolled hemorrhage remains the leading cause of preventable mortality in both civilian and military trauma sectors. The paradigm of resuscitation has decisively shifted from aggressive crystalloid administration to Damage Control Resuscitation, centering on early hemostatic control and the mitigation of the “Lethal Diamond ...
Jonghee Han, Junepill Seok, Su Young Yoon, Jin‐Uk Choi, Jin Suk Lee, Younghoon Sul   +5 more
wiley   +1 more source

Acute Neurological Manifestations in COVID‐19 Are Associated With Complement Activation and Glia‐Promoted Neuroinflammation

Journal of Medical Virology, Volume 98, Issue 10, October 2026.
ABSTRACT Pathophysiological mechanisms of neurological manifestations in COVID‐19 are not fully known yet. In this case‐control study, proteomic analysis was used to characterize cerebrospinal fluid (CSF) samples from COVID‐19 patients with acute neurological manifestations primarily categorized as: isolated refractory headache (n = 12), encephalopathy
Nicole Lardini Freitas, Yago Côrtes Pinheiro Gomes, Fábio César Sousa Nogueira, Juliana Echevarria‐Lima, João Victor Carvalho Deus, Carlos Otávio Brandão, Cristiane Nascimento Soares, Marcus Tulius Teixeira Silva, Otávio Melo Espíndola   +8 more
wiley   +1 more source

Plasma PF4 is a reliable biomarker of platelet reactivity and predictive of bleeding risk in DAPT patients undergoing cardiac surgery

Thrombosis Journal
Background Platelet activation is crucial for hemostasis and thrombosis, particularly in patients on antiplatelet therapy. Managing bleeding risk during cardiac surgery requires understanding platelet dynamics, especially when antiplatelet agents are ...
Joseph Roux de Bezieux, Julien Amour, Aurélien Philippe, Jeanne Rancic, Nicolas Gendron, Sébastien Bertil, Marc Garnier, Pascale Gaussem, David M. Smadja   +8 more
doaj   +1 more source

Modern trends in medicine: from microbiome to systemic complications

Акушерство, гинекология и репродукция
The articles in this issue cover a wide range of topics, including the role of the maternal microbiome in fetal growth restriction, the effectiveness of therapy for mixed vaginitis, management strategies for pregnant women with COVID-19, the impact of ...
A. D. Makatsariya, A. V. Vorobev
doaj   +1 more source

Prognostic Value of the Endothelial Activation and Stress Index (EASIX) in Critically Ill Patients With Ischemic Stroke: A MIMIC‐IV Database Analysis

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Background Systemic endothelial dysfunction is a critical driver of poor outcomes in ischemic stroke. We evaluated the prognostic value of the endothelial activation and stress index (EASIX) in critically ill stroke patients. Methods We analyzed 3063 patients with ischemic stroke from the MIMIC‐IV database.
Wen Bai, Manli Tao, Shaofei Li, Wei Shi, Kun Jiang, Ling Tian   +5 more
wiley   +1 more source

Hepatic Mechanisms and Therapeutic Target Underpinning Hypercoagulation in Obesity: Insights From Genetic and Transcriptomic Analyses

Exploration, Volume 6, Issue 4, August 2026.
Obesity‐linked hypercoagulation is driven by fibrinogen overproduction in a specific hepatocyte cluster via IL6 signalling. Genetic and mechanistic studies reveal this pathway as a key target for therapies to mitigate clotting risks and associated complications in obese individuals.
Shumin Li, Gengchen Feng, Xin Huang, Xiao Teng, Ziyi Yang, Yue Liu, Yonghui Jiang, Tao Zhu, Teng Liu, Yunfei Xu, Chang Pan, Han Zhao, Shaozhuang Liu, Shigang Zhao, Zi‐Jiang Chen   +14 more
wiley   +1 more source

Hypertensive retinopathy in pre‐eclampsia and its association with disease severity and neonatal outcomes: A retrospective cohort study

International Journal of Gynecology &Obstetrics, Volume 174, Issue 1, Page 229-234, July 2026.
Abstract Introduction Pre‐eclampsia (PE) involves systemic endothelial dysfunction and microvascular injury, yet routine obstetric care lacks noninvasive readouts of maternal microvascular health. We evaluated whether hypertensive retinopathy (HR) detected during pregnancy is associated with maternal disease severity and adverse neonatal outcomes ...
Gabriele Saccone, Francesco Matarazzo, Mariarosaria Motta, Marika Rovetto, Michele Rinaldi, Maurizio Guida, Ciro Costagliola   +6 more
wiley   +1 more source

Defibrotide for Protecting Against and Managing Endothelial Injury in Hematologic Malignancies and COVID-19

Biomolecules
Defibrotide, which is approved for treating hepatic veno-occlusive disease (VOD)/sinusoidal obstruction syndrome (SOS), exhibits pleiotropic anti-inflammatory, anti-thrombotic, and fibrinolytic properties, conferring broad endothelial protective effects.
Edward Richardson, Clifton C. Mo, Eleonora Calabretta, Francesco Corrado, Mehmet H. Kocoglu, Rebecca M. Baron, Jean Marie Connors, Massimo Iacobelli, Lee-Jen Wei, Emily J. Benjamin, Aaron P. Rapoport, Maribel Díaz-Ricart, Antonio José Martínez-Mellado, Carmelo Carlo-Stella, Paul G. Richardson, José M. Moraleda   +15 more
doaj   +1 more source

Global Consultation for Clinical Xenotransplantation: International Xenotransplantation Association Consensus and Communiqué Update

Xenotransplantation, Volume 33, Issue 4, July/August 2026.
ABSTRACT Xenotransplantation has entered a phase of accelerated clinical translation, necessitating renewed international consensus on governance, ethics, safety, and regulatory oversight. In September 2025, the International Xenotransplantation Association (IXA), in partnership with The Transplantation Society (TTS) and with engagement from the World ...
Wayne J. Hawthorne, Eckhard Wolf, Peter J. Cowan, Wei Wang, Ik Jin Yun, Paolo Brenner, Greg Korbutt, Raphael P. H. Meier, Megan Sykes, Léo H. Bühler, Linda Scobie, Olga Garkavenko, Hyunil Kim, Daniel J. Hurst, Richard N. Pierson III, Robert Rieben, Manuel Pascual, Nicole Scholes‐Robertson, Emanuele Cozzi, Adrián Abalovich, Alexandre Loupy, Hidetaka Hara, Rita Bottino, Burcin Ekser, Muhammad M. Mohiuddin, Jay Fishman   +25 more
wiley   +1 more source

Photobiomodulation restores blood–brain barrier integrity after hypoxia via endothelial von Willebrand factor modulation in a humanised tricellular transwell model

The Journal of Physiology, Volume 604, Issue 14, Page 6080-6103, 15 July 2026.
Abstract figure legend Photobiomodulation restores blood–brain barrier (BBB) integrity following hypoxic stress. A multicellular human BBB model comprising brain microvascular endothelial cells, astrocytes and pericytes was established in a transwell system and subjected to acute hypoxia.
Mirriam Domocos, Denis E. Bragin, Nagesh C. Shanbhag, Luise Schlotterose, Mootaz M. Salman   +4 more
wiley   +1 more source