Results 51 to 60 of about 3,316 (159)

Modern trends in medicine: from microbiome to systemic complications

Акушерство, гинекология и репродукция
The articles in this issue cover a wide range of topics, including the role of the maternal microbiome in fetal growth restriction, the effectiveness of therapy for mixed vaginitis, management strategies for pregnant women with COVID-19, the impact of ...
A. D. Makatsariya, A. V. Vorobev
doaj   +1 more source

Inflammatory Stewardship—A Perspective for Active Management of Acute Inflammation

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Inflammatory stewardship frames inflammation as a manageable clinical domain requiring explicit strategy, governance, and feedback. It aligns diagnostics, risk stratification, biomarker interpretation, and immunomodulatory decisions across perioperative and critical‐care teams.
Lennart Finn Herrlich, Hubert Schrezenmeier, David Alexander Christian Messerer   +2 more
wiley   +1 more source

Opposing Association of Lung Neutrophils and PD‐L1+ Monocytes in Age‐Related Severity of SARS‐CoV‐2 Infection

Aging Cell, Volume 25, Issue 6, June 2026.
Aging skews pulmonary myeloid responses during acute SARS‐CoV‐2 infection toward severe disease. Disease progression is characterized by excessive lung neutrophil accumulation together with impaired activation of classical monocytes, including a defect in PD‐L1 upregulation.
Serban Morosan, Clémence Granier, Noëlline Guillou, Selma Bennacer, Eléonore Weber‐Delacroix, Julianne Peronnet, François Lanthiez, Sandrine Barthelemy, Christelle Enond, Jean‐Luc Diehl, Elena Paillaud, Carine El‐Sissy, Anne‐Geneviève Marcelin, Vincent Calvez, Stéphane Marot, Amélie Guihot, Christophe Parizot, Karim Dorgham, Guy Gorochov, Christophe Combadière, Alexandre Boissonnas   +20 more
wiley   +1 more source

Endothelial Glycocalyx, Mucin, and Glycan: A Hierarchical Synthesis From Molecular Building Blocks to Supramolecular Functional Barriers

Microcirculation, Volume 33, Issue 4, May 2026.
ABSTRACT Glycans encode molecular information, but the endothelial glycocalyx is an organized, multicomponent supramolecular structure whose architecture integrates glycan cues into coherent vascular responses in vivo. The vascular endothelial glycocalyx (eGCX) is a flow‐conditioned, membrane‐coupled surface layer that mediates mechanotransduction ...
Hiroyuki Tomita, Akio Suzuki, Hideshi Okada   +2 more
wiley   +1 more source

Defibrotide for Protecting Against and Managing Endothelial Injury in Hematologic Malignancies and COVID-19

Biomolecules
Defibrotide, which is approved for treating hepatic veno-occlusive disease (VOD)/sinusoidal obstruction syndrome (SOS), exhibits pleiotropic anti-inflammatory, anti-thrombotic, and fibrinolytic properties, conferring broad endothelial protective effects.
Edward Richardson, Clifton C. Mo, Eleonora Calabretta, Francesco Corrado, Mehmet H. Kocoglu, Rebecca M. Baron, Jean Marie Connors, Massimo Iacobelli, Lee-Jen Wei, Emily J. Benjamin, Aaron P. Rapoport, Maribel Díaz-Ricart, Antonio José Martínez-Mellado, Carmelo Carlo-Stella, Paul G. Richardson, José M. Moraleda   +15 more
doaj   +1 more source

Age-related differences in circulating heparanase-1 activity in sepsis and correlation with systemic vascular endotheliopathy

Frontiers in Medicine
BackgroundHeparanase-1 (HPSE)-mediated degradation of endothelial glycocalyx heparan sulfate (HS) contributes to vascular endotheliopathy in sepsis, yet age-dependent differences in HPSE biology remain undefined.
Colin J. Sallee, Aaron S. Noa, Mouli Bhowmik, Amber C. Nobles, Zhangjie Wang, Jian Liu, Jillian R. Richter, J. Edwin Blalock, Rakesh P. Patel, Amit Gaggar, Robert P. Richter   +10 more
doaj   +1 more source

Evaluation of an IgG anti-PF4/H chemiluminescent immunoassay in the diagnosis of heparin-induced thrombocytopenia

Blood Vessels, Thrombosis & Hemostasis
: Heparin-induced thrombocytopenia (HIT) is a life-threatening complication of heparin therapy, mediated by immunoglobulin G (IgG) antibodies targeting platelet factor 4/heparin (PF4/H) complexes.
Carla Rial, Nicolas Gendron, Christine Le Beller, Shaya Sable, Aurélie Sarthou, Laetitia Mauge, Justine Piazza, Roya Nili, Maude Laney, Isabelle Presot, Jean-Luc Diehl, Anne Godier, Agnès Lillo-Le Louet, David M. Smadja, Dominique Helley   +14 more
doaj   +1 more source

Elevating the standards of hypofibrinogenemia in trauma: Higher thresholds of admission fibrinogen predict mortality and organ dysfunction

Transfusion, Volume 66, Issue S1, Page S216-S223, May 2026.
Abstract Background The precise thresholds at which admission fibrinogen predicts mortality and organ dysfunction in trauma patients are unknown. Study Design and Methods Retrospective study at a single trauma center. Inclusion criteria: 18–89 years, traumatic mechanism, transported from scene, and fibrinogen obtained within 30‐min of arrival ...
Justin Richards, Joseph Kufera, Mary Burgoyne, Deborah Stein, Rosemary Kozar   +4 more
wiley   +1 more source

Endotheliopathy is associated with higher levels of cell-free DNA following major trauma: A prospective observational study. [PDF]

PLoS ONE, 2017
Cell free deoxyribonucleic acid (cfDNA) has been proposed as a biomarker of secondary complications following trauma. Raised thrombomodulin and syndecan-1 levels have been used to indicate endotheliopathy, and are associated with inflammation ...
David N Naumann, Jon Hazeldine, Robert J Dinsdale, Jon R Bishop, Mark J Midwinter, Paul Harrison, Sam D Hutchings, Janet M Lord   +7 more
doaj   +1 more source

Single‐Cell Metabolic Imaging Reveals Glycogen‐Driven Adaptations in Endothelial Cells

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Single‐cell metabolic imaging of diabetes‐associated endothelial dysfunction by SRS microscopy reveals dynamic glycogen storage and its role in modulating metabolic adaptations under glucose starvation. Abstract Endothelial dysfunction (ED) is a defining feature of diabetes mellitus (DM) and a key contributor to many metabolic and cardiovascular ...
Rahuljeet S. Chadha, Benjamin Yang, Dongqiang Yuan, Edmund D. Kapelczak, Philip A. Kocheril, Alonso Tapia, Shivansh Mahajan, Adrian Colazo, Naseeb K. Malhi, Joseph A. Ambarian, Xuejing Liu, Tara A. TeSlaa, Zhen B. Chen, Lu Wei   +13 more
wiley   +1 more source