Results 31 to 40 of about 3,316 (159)

Persistent endotheliopathy in the pathogenesis of long COVID syndrome [PDF]

Journal of Thrombosis and Haemostasis, 2021
Persistent symptoms including breathlessness, fatigue, and decreased exercise tolerance have been reported in patients after acute SARS-CoV-2 infection. The biological mechanisms underlying this "long COVID" syndrome remain unknown. However, autopsy studies have highlighted the key roles played by pulmonary endotheliopathy and microvascular ...
Helen Fogarty, Liam Townsend, Hannah Morrin, Azaz Ahmad, Claire Comerford, Ellie Karampini, Hanna Englert, Mary Byrne, Colm Bergin, Jamie M. O’Sullivan, Ignacio Martin‐Loeches, Parthiban Nadarajan, Ciaran Bannan, Patrick W. Mallon, Gerard F. Curley, Roger J.S. Preston, Aisling M. Rehill, Dennis McGonagle, Cliona Ni Cheallaigh, Ross I. Baker, Thomas Renné, Soracha E. Ward, James S. O’Donnell, Niamh O’Connell, Kevin Ryan, Dermot Kenny, Judicael Fazavana   +26 more
openaire   +3 more sources

Sepsis and septic shock: endothelial molecular pathogenesis associated with vascular microthrombotic disease

Thrombosis Journal, 2019
In addition to protective “immune response”, sepsis is characterized by destructive “endothelial response” of the host, leading to endotheliopathy and its molecular dysfunction. Complement activation generates membrane attack complex (MAC).
Jae C. Chang
doaj   +1 more source

Glycocalyx degradation and the endotheliopathy of viral infection

PLOS ONE, 2022
The endothelial glycocalyx (EGX) contributes to the permeability barrier of vessels and regulates the coagulation cascade. EGX damage, which occurs in numerous disease states, including sepsis and trauma, results in endotheliopathy. While influenza and other viral infections are known to cause endothelial dysfunction, their effect on the EGX has not ...
Sharven Taghavi, Sarah Abdullah, Farhana Shaheen, Lauren Mueller, Brennan Gagen, Juan Duchesne, Chad Steele, Derek Pociask, Jay Kolls, Olan Jackson-Weaver   +9 more
openaire   +4 more sources

Efficacies of S-nitrosoglutathione (GSNO) and GSNO reductase inhibitor in SARS-CoV-2 spike protein induced acute lung disease in mice

Frontiers in Pharmacology, 2023
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which initially surfaced in late 2019, often triggers severe pulmonary complications, encompassing various disease mechanisms such as intense lung inflammation, vascular dysfunction, and ...
Judong Kim, Fei Qiao, Avtar K. Singh, Avtar K. Singh, Jeseong Won, Inderjit Singh, Inderjit Singh   +6 more
doaj   +1 more source

ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients

Cells, 2021
Endotheliopathy is suggested to be an important feature of COVID-19 in hospitalized patients. To determine whether endotheliopathy is involved in COVID-19-associated mortality, markers of endothelial damage were assessed in critically ill COVID-19 ...
Alice G. Vassiliou, Chrysi Keskinidou, Edison Jahaj, Parisis Gallos, Ioanna Dimopoulou, Anastasia Kotanidou, Stylianos E. Orfanos   +6 more
doaj   +1 more source

The effect of prostacyclin (Iloprost) infusion at a dose of 1 ng/kg/min for 72 hours compared to placebo in mechanically ventilated patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial

Trials, 2020
Objectives To investigate the effect of continuous infusion of the potential endothelial cytoprotective agent prostacyclin (Iloprost) 1 ng/kg/min vs. placebo for 72 hours on pulmonary endotheliopathy in mechanically ventilated COVID-19 patients.
Pär Ingemar Johansson, Morten Bestle, Peter Søe-Jensen, Klaus Tjelle Kristiansen, Jakob Stensballe, Niels Erikstrup Clausen, Anders Perner   +6 more
doaj   +1 more source

Vascular Remodeling in Pulmonary Arterial Hypertension: The Potential Involvement of Innate and Adaptive Immunity

Frontiers in Medicine, 2021
Pulmonary arterial hypertension (PAH) is a severe disease with high morbidity and mortality. Current therapies are mainly focused on vasodilative agents to improve prognosis.
Rachid Tobal, Judith Potjewijd, Vanessa P. M. van Empel, Renee Ysermans, Leon J. Schurgers, Chris P. Reutelingsperger, Jan G. M. C. Damoiseaux, Pieter van Paassen   +7 more
doaj   +1 more source

Pathomorphological changes in pulmonary vessels at different terms of lethal outcomes of patients with COVID-19

Медицинский вестник Юга России, 2021
Objective: to study the pathomorphological changes in the vessels of the lungs at different times of death in patients with COVID-19. Material and methods: autopsy protocols of 40 deaths from COVID-19 with histological, histochemical examination, and ...
S. S. Todorov, V. Yu. Deribas, A. S. Kazmin, G. L. Reznikova, Yu. M. Makarenko, F. V. Polesovoy, S. S. Todorov (jr)   +6 more
doaj   +1 more source

Phacoemulsification in the Setting of Corneal Endotheliopathies: A Review

International Ophthalmology Clinics, 2020
With the evolution of endothelial keratoplasty, surgical approaches in patient with cataracts and coexisting corneal endotheliopathies have also changed. This article aims to review the factors that determine proper procedure selection, preoperative planning, and surgical modifications during phacoemulsification in order to optimize visual outcomes and
Victoria S, Chang, Allister, Gibbons, Carla, Osigian   +2 more
openaire   +3 more sources

Pars Planitis and Autoimmune Endotheliopathy

American Journal of Ophthalmology, 1986
A migrating endothelial rejection line is the clinical criterion of specific immune reaction in corneal allotransplantation. This line when seen in otherwise intact corneas has been presumed to be an autoimmune endotheliopathy. We have recorded corneal changes similar to autoimmune endotheliopathy in four of ten patients with the diagnosis of pars ...
A A, Khodadoust, Y, Karnama, K M, Stoessel, J E, Puklin   +3 more
openaire   +2 more sources