Annals of Surgery Open, 2022 Objectives:. Determine associations between biomarkers of endotheliopathy, 24-hour fibrinolysis phenotypes and clinical outcomes after trauma. Background:. The vascular endothelium is a critical regulator of hemostasis and organ function.
Robert P. Richter, MD +8 more
doaj +2 more sources
Concomitant Traumatic Brain Injury Exacerbates Endotheliopathy in Patients with Spinal Cord Injury [PDF]
Neurotrauma ReportsNeurotrauma can cause endothelial dysfunction, characterized by neurovascular barrier disruption, tissue edema, neuroinflammation, and coagulation abnormalities, all of which may contribute to secondary injuries and worsened clinical outcomes.
Shahab Hafezi +9 more
doaj +2 more sources
Case Report: Endothelial-targeted bridging therapy for a TTP-like phenotype in fulminant iMCD-TAFRO [PDF]
Frontiers in ImmunologyBackgroundiMCD-TAFRO (the TAFRO clinical subtype of idiopathic multicentric Castleman disease (iMCD)) is characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly.
Jing Du +6 more
doaj +2 more sources
Persistent endotheliopathy in the pathogenesis of long COVID syndrome [PDF]
, 2021 Background: Persistent symptoms including breathlessness, fatigue, and decreased exercise tolerance have been reported in patients after acute SARS-CoV-2 infection. The biological mechanisms underlying this "long COVID" syndrome remain unknown.
Claire Comerford (9198266) +23 more
core +6 more sources
Endotheliopathy is associated with higher levels of cell-free DNA following major trauma: A prospective observational study. [PDF]
PLoS ONE, 2017 Cell free deoxyribonucleic acid (cfDNA) has been proposed as a biomarker of secondary complications following trauma. Raised thrombomodulin and syndecan-1 levels have been used to indicate endotheliopathy, and are associated with inflammation ...
David N Naumann +7 more
doaj +3 more sources
m-EASIX (better than EASIX) predicts severe CAR T-cell toxicities, worse overall survival, and discriminates cytokine release syndrome from sepsis [PDF]
Frontiers in ImmunologyBackgroundCytokine Release Syndrome (CRS) and Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS) are life-threatening complications that often arise after CAR T-cell immunotherapy. Endothelial dysfunction is believed to play a central role in
Ana Belén Moreno-Castaño +52 more
doaj +2 more sources
Disseminated intravascular coagulation: new identity as endotheliopathy-associated vascular microthrombotic disease based on in vivo hemostasis and endothelial molecular pathogenesis [PDF]
Thrombosis Journal, 2020 Disseminated intravascular coagulation (DIC) can be correctly redefined as disseminated intravascular microthrombosis based on “two-path unifying theory” of in vivo hemostasis.
Jae C. Chang
doaj +2 more sources
Identification of Prognostic Factors and Regulatory Pathways in Porto-Sinusoidal Vascular Disorder. [PDF]
Liver IntABSTRACT Background and Aims Porto‐sinusoidal vascular disorder (PSVD) is a rare liver condition characterized by specific histological features primarily affecting the hepatic sinusoidal and periportal vasculature, in the absence of cirrhosis. This study aimed to identify prognostic factors and regulatory pathways associated with PSVD by integrating ...
Heo S +19 more
europepmc +2 more sources
Estrogen as a therapeutic agent: Targeting endotheliopathy and coagulopathy in trauma. [PDF]
TransfusionAbstract Background Traumatic injury remains a leading cause of death, often due to uncontrolled hemorrhage and trauma‐induced coagulopathy (TIC). TIC is critically triggered by the endotheliopathy of trauma, involving endothelial cell injury and glycocalyx degradation. Despite conventional advances, the stable casualty rate underscores the urgent need
Raghavan N +4 more
europepmc +2 more sources
Inhalation Injury Is Associated With Endotheliopathy and Abnormal Fibrinolytic Phenotypes in Burn Patients: A Cohort Study [PDF]
, 2022 Burn injury is associated with endothelial dysfunction and coagulopathy and concomitant inhalation injury (IHI) increases morbidity and mortality. The aim of this work is to identify associations between IHI, coagulation homeostasis, vascular endothelium,
Moffatt, Lauren T. +9 more
core +5 more sources