Results 41 to 50 of about 3,316 (159)

Rare variants in complement system genes associate with endothelial damage after pediatric allogeneic hematopoietic stem cell transplantation

Frontiers in Immunology, 2023
IntroductionComplement system has a postulated role in endothelial problems after hematopoietic stem cell transplantation (HSCT). In this retrospective, singlecenter study we studied genetic complement system variants in patients with documented ...
Lilli Leimi, Jessica R. Koski, Jessica R. Koski, Jessica R. Koski, Outi Kilpivaara, Outi Kilpivaara, Outi Kilpivaara, Outi Kilpivaara, Kim Vettenranta, A. Inkeri Lokki, Seppo Meri, Seppo Meri   +11 more
doaj   +1 more source

The polyanionic drug suramin neutralizes histones and prevents endotheliopathy [PDF]

The Journal of Immunology, 2021
Abstract Drugs are needed to protect against the neutrophil-derived histones responsible for endothelial injury in acute inflammatory conditions such as trauma and sepsis. Heparin and other polyanions can neutralize histones but may cause secondary, deleterious effects such as excessive bleeding.
Nuria Villalba, Adrian M Sackheim, Michael A Lawson, Laurel Haines, Yen-Lin Chen, Swapnil K Sonkusare, Yong-Tao Ma, Jianing Li, Devdoot Majumdar, Beth A Bouchard, Jonathan E Boyson, Matthew E Poynter, Mark T Nelson, Kalev Freeman   +13 more
openaire   +2 more sources

9.CORNEAL ENDOTHELIOPATHY IN PSEUDOEXFOLIATION SYNDROME

The Iraqi Journal of Medical Sciences, 2018
Background: Pseudoexfoliation syndrome is a common disorder with a wide range of ophthalmic presentation and risks. Corneal endotheliopathy is one of these presentations.
Alyaà A. Kareem, Giyath Aldeen T. Neamah   +1 more
doaj   +6 more sources

Thrombotic storm, hemostasis disorders and thromboinflammation in COVID-19

Акушерство, гинекология и репродукция, 2021
The rate of thrombosis and disseminated intravascular coagulation (DIC) has been increasing in COVID-19 patients. Key features related to such condition include minimal or no risk of bleeding, moderate thrombocytopenia, high plasma fibrinogen as well as ...
A. D. Makatsariya, E. V. Slukhanchuk, V. O. Bitsadze, J. Kh. Khizroeva, M. V. Tretyakova, A. S. Shkoda, S. V. Akinshina, N. A. Makatsariya, V. I. Tsibizova, J.-C. Gris, I. Elalamy, С. Ay, E. Grandone   +12 more
doaj   +1 more source

Circulating MR-proADM levels, as an indicator of endothelial dysfunction, for early risk stratification of mid-term mortality in COVID-19 patients

International Journal of Infectious Diseases, 2021
Objectives: Thromboinflammation, resulting from a complex interaction between thrombocytopathy, coagulopathy, and endotheliopathy, contributes to increased mortality in COVID-19 patients.
Luis García de Guadiana-Romualdo, Mónica Martínez Martínez, María Dolores Rodríguez Mulero, Patricia Esteban-Torrella, Marta Hernández Olivo, María José Alcaraz García, Valerio Campos-Rodríguez, Natalia Sancho-Rodríguez, María Galindo Martínez, Antonia Alcaraz, María Salomé Ros Braquehais, Carlos Báguena Perez-Crespo, Verónica Ramos Arenas, Cristina Tomás Jiménez, Luciano Consuegra-Sánchez, Andrés Conesa-Hernandez, Pascual Piñera-Salmerón, Enrique Bernal-Morell   +17 more
doaj   +1 more source

Potential for infusion correction of COVID-19-associated endotheliopathy

Терапевтический архив, 2023
Aim. To evaluate the relationship between the systemic inflammatory response and the severity of COVID-19-associated endotheliopathy and the effect of succinate-containing crystalloid solution (sodium meglumine succinate) on it in patients with severe ...
Ionas S. Simutis, Viacheslav A. Ratnikov, Alexey N. Scheglov, Olga V. Nikolaeva, Gennady A. Boyarinov, Alexander A. Sapegin, Larisa B. Gaikovaya, Darya A. Evteeva, Ksenia N. Zamyatina   +8 more
doaj   +1 more source

Hypertensive retinopathy in pre‐eclampsia and its association with disease severity and neonatal outcomes: A retrospective cohort study

International Journal of Gynecology &Obstetrics, Volume 174, Issue 1, Page 229-234, July 2026.
Abstract Introduction Pre‐eclampsia (PE) involves systemic endothelial dysfunction and microvascular injury, yet routine obstetric care lacks noninvasive readouts of maternal microvascular health. We evaluated whether hypertensive retinopathy (HR) detected during pregnancy is associated with maternal disease severity and adverse neonatal outcomes ...
Gabriele Saccone, Francesco Matarazzo, Mariarosaria Motta, Marika Rovetto, Michele Rinaldi, Maurizio Guida, Ciro Costagliola   +6 more
wiley   +1 more source

Global Consultation for Clinical Xenotransplantation: International Xenotransplantation Association Consensus and Communiqué Update

Xenotransplantation, Volume 33, Issue 4, July/August 2026.
ABSTRACT Xenotransplantation has entered a phase of accelerated clinical translation, necessitating renewed international consensus on governance, ethics, safety, and regulatory oversight. In September 2025, the International Xenotransplantation Association (IXA), in partnership with The Transplantation Society (TTS) and with engagement from the World ...
Wayne J. Hawthorne, Eckhard Wolf, Peter J. Cowan, Wei Wang, Ik Jin Yun, Paolo Brenner, Greg Korbutt, Raphael P. H. Meier, Megan Sykes, Léo H. Bühler, Linda Scobie, Olga Garkavenko, Hyunil Kim, Daniel J. Hurst, Richard N. Pierson III, Robert Rieben, Manuel Pascual, Nicole Scholes‐Robertson, Emanuele Cozzi, Adrián Abalovich, Alexandre Loupy, Hidetaka Hara, Rita Bottino, Burcin Ekser, Muhammad M. Mohiuddin, Jay Fishman   +25 more
wiley   +1 more source

Syndecan-1: A Quantitative Marker for the Endotheliopathy of Trauma [PDF]

Journal of the American College of Surgeons, 2017
BACKGROUND: Endothelial glycocalyx breakdown elicits syndecan-1 shedding and endotheliopathy of trauma (EoT). We hypothesized that a cutoff syndecan-1 level can identify patients with endothelial dysfunction who would have poorer outcomes.
Gonzalez Rodriguez, Erika, Ostrowski, Sisse R., Cardenas, Jessica C., Baer, Lisa A., Tomasek, Jeffrey S., Henriksen, Hanne H., Stensballe, Jakob, Cotton, Bryan A., Holcomb, John B., Johansson, Pär I., Wade, Charles E.   +10 more
openaire   +3 more sources

Photobiomodulation restores blood–brain barrier integrity after hypoxia via endothelial von Willebrand factor modulation in a humanised tricellular transwell model

The Journal of Physiology, Volume 604, Issue 14, Page 6080-6103, 15 July 2026.
Abstract figure legend Photobiomodulation restores blood–brain barrier (BBB) integrity following hypoxic stress. A multicellular human BBB model comprising brain microvascular endothelial cells, astrocytes and pericytes was established in a transwell system and subjected to acute hypoxia.
Mirriam Domocos, Denis E. Bragin, Nagesh C. Shanbhag, Luise Schlotterose, Mootaz M. Salman   +4 more
wiley   +1 more source