Results 21 to 30 of about 3,916 (146)

Platelet-derived S100A9 contributes to endotheliopathy in alcohol-associated hepatitis. [PDF]

JCI Insight
Alcohol-associated liver disease (ALD) is a growing global health concern, with alcohol-associated hepatitis (AH) leading to the highest morbidity and mortality. Available therapies are limited and often inadequate.
Kirlin F, Fattahi N, Garcia-Milian R, Collin F, Wang W, Kim Y, Lucien F, Sun Z, Lam TT, Hwa J, Iwakiri Y, McConnell MJ.   +11 more
europepmc   +2 more sources

Inflammatory Cytokines Outperform Endotheliopathy Markers as Early Predictors of Mortality in Trauma [PDF]

Journal of Surgical Research
Timothy Pritts, Adam Price, Ellen Becker
exaly   +2 more sources

Perspective: Drawing on Findings From Critical Illness to Explain Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Frontiers in Medicine, 2022
We propose an initial explanation for how myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) could originate and perpetuate by drawing on findings from critical illness research.
Dominic Stanculescu, Jonas Bergquist, Jonas Bergquist   +2 more
doaj   +1 more source

Pathophysiology of Cardiac Injury in COVID-19 Patients with Acute Ischaemic Stroke: What Do We Know So Far?—A Review of the Current Literature

Life, 2022
With the onset of the COVID-19 pandemic, it became apparent that, in addition to pulmonary infection, extrapulmonary manifestations such as cardiac injury and acute cerebrovascular events are frequent in patients infected with SARS-CoV-2, worsening ...
Daniela Schoene, Luiz G. Schnekenberg, Lars-Peder Pallesen, Jessica Barlinn, Volker Puetz, Kristian Barlinn, Timo Siepmann   +6 more
doaj   +1 more source

Resuscitation-associated endotheliopathy (RAsE): a conceptual framework based on a systematic review and meta-analysis

, 2023
Introduction Shock-induced endotheliopathy (SHINE), defined as a profound sympathoadrenal hyperactivation in shock states leading to endothelial activation, glycocalyx damage, and eventual compromise of end-organ perfusion, was first described in 2017 ...
Hoe, Louise E See, Suen, Jacky Y, Obonyo, NG, Schneider, B, Maitland, Kathryn, Schneider, Bailey, Fanning, JP, Sela, DP, Raman, S, Rachakonda, Reema, Rachakonda, R, Hoe, LES, Sela, Declan P, Maitland, K, Fanning, Jonathon P, Suen, JY, Fraser, JF, Obonyo, Nchafatso G, Raman, Sainath, Fraser, John F, Bassi, Gianluigi Li, Bassi, GL   +21 more
core   +1 more source

Platelets amplify endotheliopathy in COVID-19 [PDF]

, 2021
Copyright © 2021 The Authors, some rights reserved; Given the evidence for a hyperactive platelet phenotype in COVID-19, we investigated effector cell properties of COVID-19 platelets on endothelial cells (ECs).
Rolling, Christina C., Tawil, Michael, Rapkiewicz, Amy V., Stapleford, Kenneth A, Fields, Alexander T, Stapleford, Kenneth A., Neal, Matthew D, Barrett, Tessa J, Hochman, Judith, Rolling, Christina C, Neal, Matthew D., Voora, Deepak, Drenkova, Kamelia, Berger, Jeffrey S., Cornwell, MacIntosh, Pittaluga, Stefania, Burgess, Hannah, Biebuyck, Antoine, Burgess, Hannah M., Kornblith, Lucy Z, Burgess, Hannah M, Barrett, Tessa J., Fields, Alexander T., Yuriditsky, Eugene, Mohr, Ian, Luttrell-Williams, Elliot, Berger, Jeffrey S, Kornblith, Lucy Z., Myndzar, Khrystyna, Cotzia, Paolo, Xia, Yuhe, Rapkiewicz, Amy V, Smith, Grace, Ruggles, Kelly   +33 more
core   +1 more source

Circulating Syndecan-1 as a Predictor of Persistent Thrombocytopenia and Lethal Outcome: A Population Study of Patients With Suspected Sepsis Requiring Intensive Care

Frontiers in Cardiovascular Medicine, 2021
Background: Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host responses to infection. Recent studies have suggested that endotheliopathy may be the common basis for multiple organ failure in sepsis.
Kosaku Hatanaka, Takashi Ito, Yutaro Madokoro, Chinatsu Kamikokuryo, Shuhei Niiyama, Shingo Yamada, Ikuro Maruyama, Yasuyuki Kakihana   +7 more
doaj   +1 more source

Pathogenesis of Two Faces of DVT: New Identity of Venous Thromboembolism as Combined Micro-Macrothrombosis via Unifying Mechanism Based on “Two-Path Unifying Theory” of Hemostasis and “Two-Activation Theory of the Endothelium”

Life, 2022
Venous thrombosis includes deep venous thrombosis (DVT), venous thromboembolism (VTE), venous microthrombosis and others. Still, the pathogenesis of each venous thrombosis is not clearly established.
Jae C. Chang
doaj   +1 more source

Clinical patterns of endothelial damage and thrombotic events in two patients with COVID‐19: A case report

Clinical Case Reports, 2021
Endotheliopathy causes COVID‐19 conflicting complications.
Minoosh Moghimi, Kasra Khodadadi, Mehdi Sarvandi   +2 more
doaj   +1 more source

Sepsis and septic shock: endothelial molecular pathogenesis associated with vascular microthrombotic disease

Thrombosis Journal, 2019
In addition to protective “immune response”, sepsis is characterized by destructive “endothelial response” of the host, leading to endotheliopathy and its molecular dysfunction. Complement activation generates membrane attack complex (MAC).
Jae C. Chang
doaj   +1 more source