Results 1 to 10 of about 3,382 (102)

Elevation of NT-proBNP Levels in Pediatric and Young Adult Hematopoietic Stem Cell Transplant Patients with Endotheliopathy [PDF]

Pediatric Reports
Background/Objectives: Hematopoietic stem cell transplantation (HSCT) in pediatric and young adult (YA) patients can lead to endotheliopathy, such as thrombotic microangiopathy (TMA), sinusoidal obstruction syndrome (SOS), and diffuse alveolar hemorrhage
Xiaomeng Yuan, Rebekah Lassiter, Saad Ghafoor   +2 more
exaly   +4 more sources

Glycocalyx biomarkers as early predictors of endotheliopathy in pediatric and young adult hematopoietic stem cell transplantation patients [PDF]

Frontiers in Oncology
IntroductionDiscovery of biomarkers predictive of endotheliopathy after hematopoietic stem cell transplant (HSCT) has the potential to more rapidly identify vulnerable patients, guide treatment decisions, track responses to therapy, and inform targets ...
Kimberly Uchida, Kimberly Uchida, Kimberly Uchida, Kris M Mahadeo, Jennifer McArthur, Jennifer McArthur, Yvonne Avent, Chia-Wei Hsu, Haitao Pan, Lama Elbahlawan, Melissa Hines, Akshay Sharma, Ruth G. Tatevossian, Sebabrata Mahapatra, Meenasri Kumbaji, Irtiza Sheikh, Ying Li, Keri Schadler, Saad Ghafoor, Saad Ghafoor   +19 more
doaj   +2 more sources

Molecular Pathogenesis of Endotheliopathy and Endotheliopathic Syndromes, Leading to Inflammation and Microthrombosis, and Various Hemostatic Clinical Phenotypes Based on “Two-Activation Theory of the Endothelium” and “Two-Path Unifying Theory” of Hemostasis

Medicina (Lithuania), 2022
Endotheliopathy, according to the “two-activation theory of the endothelium”, can be triggered by the activated complement system in critical illnesses, such as sepsis and polytrauma, leading to two distinctly different molecular dysfunctions: (1) the ...
Jae C Chang
exaly   +3 more sources

Age-related differences in circulating heparanase-1 activity in sepsis and correlation with systemic vascular endotheliopathy [PDF]

Frontiers in Medicine
BackgroundHeparanase-1 (HPSE)-mediated degradation of endothelial glycocalyx heparan sulfate (HS) contributes to vascular endotheliopathy in sepsis, yet age-dependent differences in HPSE biology remain undefined.
Colin J. Sallee, Aaron S. Noa, Mouli Bhowmik, Amber C. Nobles, Zhangjie Wang, Jian Liu, Jillian R. Richter, J. Edwin Blalock, Rakesh P. Patel, Amit Gaggar, Robert P. Richter   +10 more
doaj   +2 more sources

The vWF/ADAMTS13 Ratio as a Potential Marker of Endotheliopathy in Malignancies [PDF]

Biomedicines
Background: Endothelial activation and thromboinflammation play an important role in cancer-associated thrombosis. An imbalance between von Willebrand factor (vWF) and its physiological regulator ADAMTS13 may reflect the development of a prothrombotic ...
Alexander Vorobev, Victoria Bitsadze, Jamilya Khizroeva, Antonina Solopova, Maria Tretyakova, Nilufar Gashimova, Kristina Grigoreva, Irina Kalashnikova, Natalia Makatsariya, Vlada Rubashkina, Yana Sulina, Aidanhanum Iskenderova, Alexandra Antonova, Dmitry Utkin, Jean-Christophe Gris, Ismail Elalamy, Grigoris Gerotziafas, Alexander Makatsariya   +17 more
doaj   +2 more sources

Immunophenotyping of septic shock patients with endotheliopathy: focus on monocyte subtypes and Immune regulatory molecules [PDF]

Frontiers in Immunology
BackgroundSeptic shock is characterized by dysregulation of the host response to infection which results in life-threatening organ dysfunction that can be partly attributed to immune alterations and endothelial dysfunction (endotheliopathy).
Saif Al-Haidar, Martin Schønemann-Lund, Mikkel Gybel-Brask, Mikkel Gybel-Brask, Jakob Stensballe, Jakob Stensballe, Lars Andresen, Pär I. Johansson, Pär I. Johansson, Morten H. Bestle, Morten H. Bestle, Søren Skov   +11 more
doaj   +2 more sources

Traumatized triad of complementopathy, endotheliopathy, and coagulopathy ˗ Impact on clinical outcomes in severe polytrauma patients

Frontiers in Immunology, 2022
Complementopathy, endotheliopathy, and coagulopathy following a traumatic injury are key pathophysiological mechanisms potentially associated with multiple-organ failure (MOF) and mortality. However, the heterogeneity in the responses of complementopathy,
Tuan Le, Milomir O Simovic
exaly   +3 more sources

The Association Between Dysglycemia and Endotheliopathy in ICU Patients With and Without Diabetes: A Cohort Study [PDF]

Critical Care Explorations
IMPORTANCE:. Dysglycemia in critically ill patients is associated with endotheliopathy. This relationship may be altered in patients with diabetes. OBJECTIVES:.
Christian Gantzel Nielsen, MD, Mikkel Thor Olsen, MD, Peter Lommer Kristensen, MD, PhD, Martin Schønemann-Lund, MD, PhD, Pär Ingemar Johansson, MD, DMSc, Ulrik Pedersen-Bjergaard, MD, DMSc, Morten Heiberg Bestle, MD, PhD   +6 more
doaj   +2 more sources

Vaccine-Associated Thrombocytopenia and Thrombosis: Venous Endotheliopathy Leading to Venous Combined Micro-Macrothrombosis

Medicina (Lithuania), 2021
Serious vaccine-associated side effects are very rare. Major complications of vaccines are thrombocytopenia and thrombosis in which pathogenetic mechanism is consistent with endotheliopathy characterized by “attenuated” sepsis-like syndrome, leading to ...
Jae C Chang, Harrison Hawley
exaly   +3 more sources

Bispecific self-assembled peptides as supra-growth factors for preventing endotheliopathy and improving survival of traumatic brain injury in mice [PDF]

Journal of Nanobiotechnology
Traumatic brain injury (TBI) causes endothelial injury (endotheliopathy), which contributes to a cascade of adverse events, including cerebral hemorrhage, edema and acute lung injury (ALI), and leads to poor clinical outcomes.
Yichi Zhang, Lanxing Wang, Dandan Li, Xingyao Sun, Zijian Zhou, Ying Zhang, Linan Jiao, Shuhong Yang, Yafan Liu, Tianrui Ma, Hao Zhang, Lujia Tang, Kaifeng Pang, Pengbo Zhao, Muyan Xu, Jie Li, Jianning Zhang, Zhimou Yang, Jie Gao, Zilong Zhao   +19 more
doaj   +2 more sources