Results 1 to 10 of about 3,316 (159)

Elevation of NT-proBNP Levels in Pediatric and Young Adult Hematopoietic Stem Cell Transplant Patients with Endotheliopathy [PDF]

Pediatric Reports
Background/Objectives: Hematopoietic stem cell transplantation (HSCT) in pediatric and young adult (YA) patients can lead to endotheliopathy, such as thrombotic microangiopathy (TMA), sinusoidal obstruction syndrome (SOS), and diffuse alveolar hemorrhage
Xiaomeng Yuan, Rebekah Lassiter, Dinesh Keerthi   +2 more
exaly   +4 more sources

Glycocalyx biomarkers as early predictors of endotheliopathy in pediatric and young adult hematopoietic stem cell transplantation patients [PDF]

Frontiers in Oncology
IntroductionDiscovery of biomarkers predictive of endotheliopathy after hematopoietic stem cell transplant (HSCT) has the potential to more rapidly identify vulnerable patients, guide treatment decisions, track responses to therapy, and inform targets ...
Kimberly Uchida, Kimberly Uchida, Kimberly Uchida, Kris M Mahadeo, Jennifer McArthur, Jennifer McArthur, Yvonne Avent, Chia-Wei Hsu, Haitao Pan, Lama Elbahlawan, Melissa Hines, Akshay Sharma, Ruth G. Tatevossian, Sebabrata Mahapatra, Meenasri Kumbaji, Irtiza Sheikh, Ying Li, Keri Schadler, Saad Ghafoor, Saad Ghafoor   +19 more
doaj   +2 more sources

Molecular Pathogenesis of Endotheliopathy and Endotheliopathic Syndromes, Leading to Inflammation and Microthrombosis, and Various Hemostatic Clinical Phenotypes Based on “Two-Activation Theory of the Endothelium” and “Two-Path Unifying Theory” of Hemostasis

Medicina (Lithuania), 2022
Endotheliopathy, according to the “two-activation theory of the endothelium”, can be triggered by the activated complement system in critical illnesses, such as sepsis and polytrauma, leading to two distinctly different molecular dysfunctions: (1) the ...
Jae Chang
exaly   +3 more sources

Estrogen as a therapeutic agent: Targeting endotheliopathy and coagulopathy in trauma. [PDF]

Transfusion
Abstract Background Traumatic injury remains a leading cause of death, often due to uncontrolled hemorrhage and trauma‐induced coagulopathy (TIC). TIC is critically triggered by the endotheliopathy of trauma, involving endothelial cell injury and glycocalyx degradation. Despite conventional advances, the stable casualty rate underscores the urgent need
Raghavan N, Patel M, Cotton BA, Coleman J, Jenkins D.   +4 more
europepmc   +2 more sources

Circulating markers of angiogenesis and endotheliopathy in COVID‐19 [PDF]

Pulmonary Circulation, 2020
Increase in thrombotic and microvascular complications is emerging to be a key feature of patients with critical illness associated with COVID‐19 infection. While endotheliopathy is thought to be a key factor of COVID‐19‐associated coagulopathy, markers indicative of this process that are prognostic of disease severity have not been well‐established in
John Hwa, Christina Price, George Goshua   +2 more
exaly   +6 more sources

Immunophenotyping of septic shock patients with endotheliopathy: focus on monocyte subtypes and Immune regulatory molecules [PDF]

Frontiers in Immunology
BackgroundSeptic shock is characterized by dysregulation of the host response to infection which results in life-threatening organ dysfunction that can be partly attributed to immune alterations and endothelial dysfunction (endotheliopathy).
Saif Al-Haidar, Martin Schønemann-Lund, Mikkel Gybel-Brask, Mikkel Gybel-Brask, Jakob Stensballe, Jakob Stensballe, Lars Andresen, Pär I. Johansson, Pär I. Johansson, Morten H. Bestle, Morten H. Bestle, Søren Skov   +11 more
doaj   +2 more sources

The Association Between Dysglycemia and Endotheliopathy in ICU Patients With and Without Diabetes: A Cohort Study [PDF]

Critical Care Explorations
IMPORTANCE:. Dysglycemia in critically ill patients is associated with endotheliopathy. This relationship may be altered in patients with diabetes. OBJECTIVES:.
Christian Gantzel Nielsen, MD, Mikkel Thor Olsen, MD, Peter Lommer Kristensen, MD, PhD, Martin Schønemann-Lund, MD, PhD, Pär Ingemar Johansson, MD, DMSc, Ulrik Pedersen-Bjergaard, MD, DMSc, Morten Heiberg Bestle, MD, PhD   +6 more
doaj   +2 more sources

Traumatized triad of complementopathy, endotheliopathy, and coagulopathy ˗ Impact on clinical outcomes in severe polytrauma patients

Frontiers in Immunology, 2022
Complementopathy, endotheliopathy, and coagulopathy following a traumatic injury are key pathophysiological mechanisms potentially associated with multiple-organ failure (MOF) and mortality. However, the heterogeneity in the responses of complementopathy,
Charles Wade, , Zhangsheng Yang
exaly   +3 more sources

The coagulopathy, endotheliopathy, and vasculitis of COVID-19 [PDF]

Inflammation Research, 2020
COVID-19-associated coagulopathy (CAC) characterized by the elevated D-dimer without remarkable changes of other global coagulation markers is associated with various thrombotic complications and disease severity. The purpose of this review is to elucidate the pathophysiology of this unique coagulopathy.The authors performed online search of published ...
Jean M Connors, Toshiaki Iba
exaly   +3 more sources

Pro- and Anti-Inflammatory Responses and Clinical Outcomes in Critically Ill Patients With Endotheliopathy: A Cohort Study. [PDF]

Acta Anaesthesiol Scand
ABSTRACT Background Multiple organ dysfunction syndrome (MODS) in critical illness involves dysregulated immune and inflammatory responses, endotheliopathy, and coagulation activation. We investigated how three types of endotheliopathy biomarkers relate to pro‐ and anti‐inflammatory responses and clinical outcomes in intensive care unit (ICU) patients.
Humble C, Schønemann-Lund M, Bruun-Rasmussen P, Bestle MH, Johansson PI, Poulsen LM, Mathiesen O.   +6 more
europepmc   +2 more sources