Hematopoietic stem cells contribute to lymphatic endothelium. [PDF]
PLoS ONE, 2008 Although the lymphatic system arises as an extension of venous vessels in the embryo, little is known about the role of circulating progenitors in the maintenance or development of lymphatic endothelium.
Shuguang Jiang +6 more
doaj +9 more sources
Immunomodulatory properties of the lymphatic endothelium in the tumor microenvironment
Frontiers in Immunology, 2023 The tumor microenvironment (TME) is an intricate complex and dynamic structure composed of various cell types, including tumor, stromal and immune cells.
Cristina Viúdez-Pareja +5 more
doaj +4 more sources
Cellular Origins of the Lymphatic Endothelium: Implications for Cancer Lymphangiogenesis [PDF]
Frontiers in Physiology, 2020 The lymphatic system plays important roles in physiological and pathological conditions. During cancer progression in particular, lymphangiogenesis can exert both positive and negative effects.
Laura Gutierrez-Miranda, Karina Yaniv
doaj +4 more sources
microRNAs in the Lymphatic Endothelium: Master Regulators of Lineage Plasticity and Inflammation [PDF]
Frontiers in Immunology, 2017 microRNAs (miRNAs) are highly conserved, small non-coding RNAs that regulate gene expression at the posttranscriptional level. They have crucial roles in organismal development, homeostasis, and cellular responses to pathological stress. The lymphatic system is a large vascular network that actively regulates the immune response through antigen ...
Yee, Daniel +2 more
semanticscholar +8 more sources
Pannexin1 deletion in lymphatic endothelium affects lymphatic function in a sex‐dependent manner [PDF]
Physiological ReportsThe lymphatic network of capillaries and collecting vessels ensures tissue fluid homeostasis, absorption of dietary fats and trafficking of immune cells.
Avigail Ehrlich +5 more
doaj +5 more sources
Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium [PDF]
Developmental Cell, 2019 Endothelial cells (ECs), which line blood and lymphatic vessels, are generally described to come from the lateral plate mesoderm despite experimental evidence for a broader source of origin, including the paraxial mesoderm (PXM). Current dogma suggests that following specification from mesoderm, local environmental cues establish the distinct molecular
Didier Y.R. Stainier +2 more
openaire +5 more sources
Calcium and electrical dynamics in lymphatic endothelium [PDF]
The Journal of Physiology, 2017 Key points Endothelial cell function in resistance arteries integrates Ca2+ signalling with hyperpolarization to promote relaxation of smooth muscle cells and increase tissue blood flow. Whether complementary signalling occurs in lymphatic endothelium is unknown.
Joshua P. Scallan +9 more
openaire +4 more sources
Frontiers in Immunology, 2021 Gradients of chemokines and growth factors guide migrating cells and morphogenetic processes. Migration of antigen-presenting dendritic cells from the interstitium into the lymphatic system is dependent on chemokine CCL21, which is secreted by ...
Kari Vaahtomeri +4 more
doaj +2 more sources
Lymphatic endothelium in health and disease [PDF]
Cell and Tissue Research, 2008 ISSN:1432 ...
Jurisic, Giorgia, Detmar, Michael
openaire +6 more sources
KSHV infection of endothelial precursor cells with lymphatic characteristics as a novel model for translational Kaposi's sarcoma studies. [PDF]
PLoS Pathogens, 2023 Kaposi's sarcoma herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS), a hyperplasia consisting of enlarged malformed vasculature and spindle-shaped cells, the main proliferative component of KS.
Krista Tuohinto +7 more
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