Results 1 to 10 of about 272,678 (276)

Shape and Function of Interstitial Chemokine CCL21 Gradients Are Independent of Heparan Sulfates Produced by Lymphatic Endothelium

Frontiers in Immunology, 2021
Gradients of chemokines and growth factors guide migrating cells and morphogenetic processes. Migration of antigen-presenting dendritic cells from the interstitium into the lymphatic system is dependent on chemokine CCL21, which is secreted by ...
Kari Vaahtomeri, Kari Vaahtomeri, Christine Moussion, Robert Hauschild, Michael Sixt   +4 more
doaj   +2 more sources

Immunomodulatory properties of the lymphatic endothelium in the tumor microenvironment

Frontiers in Immunology, 2023
The tumor microenvironment (TME) is an intricate complex and dynamic structure composed of various cell types, including tumor, stromal and immune cells.
Cristina Viúdez-Pareja, Cristina Viúdez-Pareja, Ewa Kreft, Ewa Kreft, Melissa García-Caballero, Melissa García-Caballero   +5 more
doaj   +2 more sources

The Intestinal Lymphatic System: Functions and Metabolic ImplicationsSummary [PDF]

Cellular and Molecular Gastroenterology and Hepatology, 2019
The lymphatic system of the gut plays important roles in the transport of dietary lipids, as well as in immunosurveillance and removal of interstitial fluid.
Vincenza Cifarelli, Anne Eichmann
doaj   +3 more sources

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and b1-integrin activation [PDF]

eLife, 2018
Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Alve, S, Balistreri, G, Gramolelli, S, Hautaniemi, S, Icay, K, Ivaska, J, Lehti, K, Niiranen, O, Ojala, PM, Paatero, I, Pekkonen, P, Perälä, N, Repo, P, Saharinen, P, Taiwo, A, Tatti-Bugaeva, O, Tuohinto, K, Zinovkina, N   +17 more
core   +2 more sources

T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions [PDF]

Cell Reports, 2017
T cells are the most abundant cell type found in afferent lymph, but their migration through lymphatic vessels (LVs) remains poorly understood. Performing intravital microscopy in the murine skin, we imaged T cell migration through afferent LVs in vivo ...
Alvaro Teijeira, Morgan C. Hunter, Erica Russo, Steven T. Proulx, Thomas Frei, Gudrun F. Debes, Marc Coles, Ignacio Melero, Michael Detmar, Ana Rouzaut, Cornelia Halin   +10 more
doaj   +5 more sources

Cellular Origins of the Lymphatic Endothelium: Implications for Cancer Lymphangiogenesis

Frontiers in Physiology, 2020
The lymphatic system plays important roles in physiological and pathological conditions. During cancer progression in particular, lymphangiogenesis can exert both positive and negative effects.
Laura Gutierrez-Miranda, Karina Yaniv
doaj   +2 more sources

Nestin as a Marker Beyond Angiogenesis—Expression Pattern in Haemangiomas and Lymphangiomas [PDF]

Biomedicines
Background: The intermediate filament nestin was first described in stem and progenitor cells of neural and mesenchymal origin. Additionally, it is expressed in endothelial cells during wound healing and tumorigenesis.
Andreas Mamilos, Lina Winter, Christoph B. Wiedenroth, Tanja Niedermair, Stefanie Zimmer, Volker H. Schmitt, Karsten Keller, Ondrej Topolčan, Marie Karlíková, Markus Rupp, Christoph Brochhausen, Cristina Cotarelo   +11 more
doaj   +2 more sources

Lymphatic disorders caused by mosaic, activating KRAS variants respond to MEK inhibition

JCI Insight, 2023
Central conducting lymphatic anomaly (CCLA) due to congenital maldevelopment of the lymphatics can result in debilitating and life-threatening disease with limited treatment options.
Sarah E. Sheppard, Michael E. March, Christoph Seiler, Leticia S. Matsuoka, Sophia E. Kim, Charlly Kao, Adam I. Rubin, Mark R. Battig, Nahla Khalek, Erica Schindewolf, Nora O’Connor, Erin Pinto, Jessica R.C. Priestley, Victoria R. Sanders, Rojeen Niazi, Arupa Ganguly, Cuiping Hou, Diana Slater, Ilona J. Frieden, Thy Huynh, Joseph T. Shieh, Ian D. Krantz, Jessenia C. Guerrero, Lea F. Surrey, David M. Biko, Pablo Laje, Leslie Castelo-Soccio, Taizo A. Nakano, Kristen Snyder, Christopher L. Smith, Dong Li, Yoav Dori, Hakon Hakonarson   +32 more
doaj   +2 more sources

Single-nuclei multiomic analyses identify human cardiac lymphatic endothelial cells associated with coronary arteries in the epicardium

Cell Reports, 2023
Summary: Cardiac lymphatic vessels play important roles in fluid homeostasis, inflammation, disease, and regeneration of the heart. The developing cardiac lymphatics in human fetal hearts are closely associated with coronary arteries, similar to those in
Stanislao Igor Travisano, Michael R.M. Harrison, Matthew E. Thornton, Brendan H. Grubbs, Thomas Quertermous, Ching-Ling Lien   +5 more
doaj   +2 more sources

Microfluidic‐Based Reconstitution of Functional Lymphatic Microvasculature: Elucidating the Role of Lymphatics in Health and Disease

Advanced Science, 2023
The knowledge of the blood microvasculature and its functional role in health and disease has grown significantly attributable to decades of research and numerous advances in cell biology and tissue engineering; however, the lymphatics (the secondary ...
Jean C. Serrano, Mark R. Gillrie, Ran Li, Sarah H. Ishamuddin, Emad Moeendarbary, Roger D. Kamm   +5 more
doaj   +2 more sources