Results 11 to 20 of about 272,678 (276)

mTOR-Dependent Stimulation of IL20RA Orchestrates Immune Cell Trafficking through Lymphatic Endothelium in Patients with Crohn’s Disease

Cells, 2019
Crohn’s disease (CD) is a chronic inflammatory condition that can affect different portions of the gastrointestinal tract. Lymphatic drainage was demonstrated to be dysfunctional in CD pathogenesis, ultimately causing the failure of the resolution ...
Federica Ungaro, Valentina Garlatti, Luca Massimino, Antonino Spinelli, Michele Carvello, Matteo Sacchi, Salvatore Spanò, Gaia Colasante, Nicholas Valassina, Stefania Vetrano, Alberto Malesci, Laurent Peyrin-Biroulet, Silvio Danese, Silvia D’Alessio   +13 more
doaj   +2 more sources

Direct specification of lymphatic endothelium from non-venous angioblasts

bioRxiv, 2022
The lymphatic vasculature is essential for tissue fluid homeostasis, immune cell surveillance and dietary lipid absorption, and has emerged as a key regulator of organ growth and repair1.
Irina-Elena Lupu, Nils Kirschnick, Sarah Weischer, I. Martinez-Corral, Aden Forrow, Ines Lahmann, P. Riley, T. Zobel, T. Makinen, F. Kiefer, Oliver A. Stone   +10 more
semanticscholar   +1 more source

Transcription Factor Control of Lymphatic Quiescence and Maturation of Lymphatic Neovessels in Development and Physiology

Frontiers in Physiology, 2021
The lymphatic system is a vascular system comprising modified lymphatic endothelial cells, lymph nodes and other lymphoid organs. The system has diverse, but critical functions in both physiology and pathology, and forms an interface between the blood ...
Zarah B. Tabrizi, Nada S. Ahmed, Joseph L. Horder, Sarah J. Storr, Andrew V. Benest   +4 more
doaj   +1 more source

Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis?

Oncogenesis, 2021
Lymphatic metastasis represents the main route of tumour cell dissemination in oral squamous cell carcinoma (OSCC). Yet, there are no FDA-approved therapeutics targeting cancer-related lymphangiogenesis to date.
Sini Karinen, K. Juurikka, Roosa Hujanen, Wafa Wahbi, E. Hadler-Olsen, G. Svineng, K. Eklund, T. Salo, P. Åström, A. Salem   +9 more
semanticscholar   +1 more source

Lymphatic Clearance of Immune Cells in Cardiovascular Disease

Cells, 2021
Recent advances in our understanding of the lymphatic system, its function, development, and role in pathophysiology have changed our views on its importance. Historically thought to be solely involved in the transport of tissue fluid, lipids, and immune
Christophe Ravaud, Nikita Ved, David G. Jackson, Joaquim Miguel Vieira, Paul R. Riley   +4 more
doaj   +1 more source

The prognostic influence of lymphatic endothelium–specific hyaluronan receptor 1 in cancer: A systematic review

Cancer Science, 2021
Lymphangiogenesis is a key process in cancer development and metastasis. Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE‐1) is a widely used marker for lymphatic endothelial cells (LEC), which also mediates immune and cancer cell migration ...
Sini Karinen, Roosa Hujanen, T. Salo, A. Salem   +3 more
semanticscholar   +1 more source

Visualization of Endothelial Actin Cytoskeleton in the Mouse Retina [PDF]

, 2012
Angiogenesis requires coordinated changes in cell shape of endothelial cells (ECs), orchestrated by the actin cytoskeleton. The mechanisms that regulate this rearrangement in vivo are poorly understood - largely because of the difficulty to visualize ...
Alessia Fraccaroli, Attila Aszodi, Claudio A Franco, Eloi Montanez, Emanuel Rognoni, Filipa Neto, Holger Gerhardt, Holger Gerhardt, Markus Rehberg, Roland Wedlich-Söldner, Ulrich Pohl   +10 more
core   +11 more sources

KSHV infection of endothelial precursor cells with lymphatic characteristics as a novel model for translational Kaposi's sarcoma studies.

PLoS Pathogens, 2023
Kaposi's sarcoma herpesvirus (KSHV) is the etiologic agent of Kaposi's sarcoma (KS), a hyperplasia consisting of enlarged malformed vasculature and spindle-shaped cells, the main proliferative component of KS.
Krista Tuohinto, Terri A DiMaio, Elina A Kiss, Pirjo Laakkonen, Pipsa Saharinen, Tara Karnezis, Michael Lagunoff, Päivi M Ojala   +7 more
doaj   +1 more source

Is It All about Endothelial Dysfunction? Focusing on the Alteration in Endothelial Integrity as a Key Determinant of Different Pathological Mechanisms

Biomedicines, 2022
The endothelium is composed of a monolayer of endothelial cells (ECs) covering the inner side of arterial, venous and lymphatic vessels [...]
Pasquale Ambrosino, Silvestro Ennio D’Anna, Guido Grassi, Mauro Maniscalco   +3 more
doaj   +1 more source

Coagulation in Lymphatic System

Frontiers in Cardiovascular Medicine, 2021
The lymphatic system maintains homeostasis of the internal environment between the cells in tissues and the blood circulation. The coagulation state of lymph is determined by conditions of coagulation factors and lymphatic vessels. Internal obliteration,
Wendi Zhang, Wendi Zhang, Wendi Zhang, Jiang Li, Jiangjiu Liang, Xiumei Qi, Jinghui Tian, Ju Liu, Ju Liu   +8 more
doaj   +1 more source