Results 11 to 20 of about 266,603 (335)

A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis [PDF]

Molecular Cancer, 2010
Background Lymph node metastasis constitutes a key event in tumor progression. The molecular control of this process is poorly understood. Heparan sulfate is a linear polysaccharide consisting of unique sulfate-modified disaccharide repeats that allow ...
Srinivasan R Sathish, Johns Scott C, Lawrence Roger, Truty Jadwiga, Yin Xin, Handel Tracy M, Fuster Mark M   +6 more
doaj   +5 more sources

The inflammatory response of lymphatic endothelium [PDF]

Angiogenesis, 2013
ISSN:1573 ...
Aebischer David, Iolyeva Maria, Halin Cornelia   +2 more
openaire   +6 more sources

Nestin as a Marker Beyond Angiogenesis—Expression Pattern in Haemangiomas and Lymphangiomas [PDF]

Biomedicines
Background: The intermediate filament nestin was first described in stem and progenitor cells of neural and mesenchymal origin. Additionally, it is expressed in endothelial cells during wound healing and tumorigenesis.
Andreas Mamilos, Lina Winter, Christoph B. Wiedenroth, Tanja Niedermair, Stefanie Zimmer, Volker H. Schmitt, Karsten Keller, Ondrej Topolčan, Marie Karlíková, Markus Rupp, Christoph Brochhausen, Cristina Cotarelo   +11 more
doaj   +2 more sources

Dendritic Cell Interactions with Lymphatic Endothelium [PDF]

Lymphatic Research and Biology, 2013
Afferent lymphatic vessels fulfill essential immune functions by transporting leukocytes and lymph-borne antigen to draining lymph nodes (dLNs). An important cell type migrating through lymphatic vessels are dendritic cells (DCs). DCs reside in peripheral tissues like the skin, where they take up antigen and transport it via the lymphatic vascular ...
Russo Erica, Nitschké Maximilian, Halin Cornelia   +2 more
openaire   +5 more sources

T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions [PDF]

Cell Reports, 2017
T cells are the most abundant cell type found in afferent lymph, but their migration through lymphatic vessels (LVs) remains poorly understood. Performing intravital microscopy in the murine skin, we imaged T cell migration through afferent LVs in vivo ...
Alvaro Teijeira, Morgan C. Hunter, Erica Russo, Steven T. Proulx, Thomas Frei, Gudrun F. Debes, Marc Coles, Ignacio Melero, Michael Detmar, Ana Rouzaut, Cornelia Halin   +10 more
doaj   +5 more sources

Emerging roles of lymphatic endothelium in regulating adaptive immunity [PDF]

Journal of Clinical Investigation, 2014
Emerging research on the roles of stromal cells in modulating adaptive immune responses has included a new focus on lymphatic endothelial cells (LECs). LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines, danger signals, and immune cells travelling from peripheral tissues to lymph nodes.
Card Catherine M., Yu Shann S., Swartz Melody A.   +2 more
openaire   +4 more sources

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation [PDF]

eLife, 2018
Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Pirita Pekkonen, Sanni Alve, G. Balistreri, Silvia Gramolelli, Olga Tatti-Bugaeva, I. Paatero, Otso Niiranen, Krista Tuohinto, Nina M Perälä, Adewale Taiwo, N. Zinovkina, P. Repo, Katherine Icay, J. Ivaska, P. Saharinen, S. Hautaniemi, K. Lehti, P. Ojala   +17 more
semanticscholar   +3 more sources

MicroRNAs secreted by the parasitic nematode Brugia malayi disrupt lymphatic endothelial cell integrity. [PDF]

PLoS Neglected Tropical Diseases
Lymphatic filariasis (LF) is a neglected tropical disease affecting over 51 million people in 72 endemic countries. Causative agents of LF are mosquito-borne parasitic nematodes Wuchereria bancrofti, Brugia malayi, and Brugia timori.
Hailey Johnson, Stephanie Banakis, Matthew Chung, Elodie Ghedin, Denis Voronin   +4 more
doaj   +2 more sources

Direct specification of lymphatic endothelium from mesenchymal progenitors. [PDF]

Nat Cardiovasc Res
Abstract During embryogenesis, endothelial cells (ECs) are generally described to arise from a common pool of progenitors termed angioblasts, which diversify through iterative steps of differentiation to form functionally distinct subtypes of ECs.
Lupu IE, Grainger DE, Kirschnick N, Weischer S, Zhao E, Martinez-Corral I, Schoofs H, Vanhollebeke M, Jones G, Godwin J, Forrow A, Lahmann I, Riley PR, Zobel T, Alitalo K, Mäkinen T, Kiefer F, Stone OA.   +17 more
europepmc   +5 more sources

Lymphatic disorders caused by mosaic, activating KRAS variants respond to MEK inhibition

JCI Insight, 2023
Central conducting lymphatic anomaly (CCLA) due to congenital maldevelopment of the lymphatics can result in debilitating and life-threatening disease with limited treatment options.
Sarah E. Sheppard, Michael E. March, Christoph Seiler, Leticia S. Matsuoka, Sophia E. Kim, Charlly Kao, Adam I. Rubin, Mark R. Battig, Nahla Khalek, Erica Schindewolf, Nora O’Connor, Erin Pinto, Jessica R.C. Priestley, Victoria R. Sanders, Rojeen Niazi, Arupa Ganguly, Cuiping Hou, Diana Slater, Ilona J. Frieden, Thy Huynh, Joseph T. Shieh, Ian D. Krantz, Jessenia C. Guerrero, Lea F. Surrey, David M. Biko, Pablo Laje, Leslie Castelo-Soccio, Taizo A. Nakano, Kristen Snyder, Christopher L. Smith, Dong Li, Yoav Dori, Hakon Hakonarson   +32 more
doaj   +2 more sources