Results 1 to 10 of about 322,021 (244)

Imbalance of Endothelium-derived Relaxing and Contracting Factors: A New Concept in Hypertension? [PDF]

, 2017
The endothelium has a strategical anatomical position between the circulating blood and vascular smooth muscle cells. It has recently been recognized that endothelial cells play an important regulatory role in the circulation.
Lüscher, T. F.
core  

Vascular biology of ageing—implications in hypertension [PDF]

, 2015
Ageing is associated with functional, structural and mechanical changes in arteries that closely resemble the vascular alterations in hypertension. Characteristic features of large and small arteries that occur with ageing and during the development of ...
Harvey, Adam, Montezano, Augusto C., Touyz, Rhian M.   +2 more
core   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Role of the endothelium and COX-1 in prostacyclin generation by whole vessels stimulated with different agonists [PDF]

, 2012
Prostacyclin is an important cardioprotective hormone produced by the vascular wall, whose synthesis is dependent on cyclo-oxygenase (COX) enzymes. In healthy vessels the endothelium is thought to be the main site of prostacyclin release (Moncada et al ...
Alyamanil, Malak, Kirkby, N.S., Lundberg, M.H., MacKenzie, Louise Susan, Mitchell, J.A., Warner, T.D.   +5 more
core  

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

The Structural Features of Vascular Endothelium in Acute Cerebral Ischemia [PDF]

, 2017
The aim of the research was to study the number and structural properties of desquamated endothelial cells (DECs) in the peripheral blood in carotid ischemic stroke (CIS) and carotid transient ischemic attacks (TIAs) and its connection with the marker of
Kosheleva, A. (Anna)
core   +2 more sources

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

Celecoxib exerts protective effects in the vascular endothelium via COX-2-independent activation of AMPK-CREB-Nrf2 signalling [PDF]

, 2018
Although concern remains about the athero-thrombotic risk posed by cyclo-oxygenase (COX)-2-selective inhibitors, recent data implicates rofecoxib, while celecoxib appears equivalent to NSAIDs naproxen and ibuprofen.
A Arfe, A Bauer, A Kardosh, A Salminen, AJ Shaywitz, B Fisslthaler, BR Gunter, C Liu, C Mo, C Patrono, CC Thornton, CH He, D Carling, DH Solomon, DM Thomson, EH Kobayashi, EL Fosbol, FY Li, H Mylroie, HP Lin, HT Cheng, I Tegeder, IE Schauer, J Lindhardsen, J Steffel, JA Mitchell, JM Cacicedo, JS Wang, K Iwasaki, K Zimmermann, LC Wu, ME Widlansky, MP Seldon, MP Soares, MT Nurmohamed, N Bhala, NJ Goodson, NM Davies, NM Davies, P Kale, PA Watson, R Chenevard, R Gozzelino, RS Bresalier, S Jacob, S Trelle, SE Nissen, SK Paulson, SK Paulson, SL Colombo, SS Hamdulay, SS Hamdulay, SW Ryter, TD Penning, TM MacDonald, VL King, WB White, X Liu, XM Liu, Y Hattori, ZQ Zou   +60 more
core   +3 more sources

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Adiponectin improves coronary no-reflow injury by protecting the endothelium in rats with type 2 diabetes mellitus. [PDF]

, 2017
To determine the effect of adiponectin (APN) on the coronary no-reflow (NR) injury in rats with Type 2 diabetes mellitus (T2DM), 80 male Sprague-Dawley rats were fed with a high-sugar-high-fat diet to build a T2DM model.
Han, Xue, Liu, Huirong, Liu, Xin, Lv, Tingting, Ma, Lu, Ma, Xin-Liang, Sun, Qi, Wang, Ke, Wang, Wen, Wu, Ye, Xu, Wenli, Zhang, Suli   +11 more
core   +2 more sources