Results 1 to 10 of about 1,648,635 (304)

Comparative study of the effects of cigarette smoke versus next generation tobacco and nicotine product extracts on endothelial function

Redox Biology, 2021
Tobacco smoking and hemodynamic forces are key stimuli for the development of endothelial dysfunction. As an alternative to smoking, next generation tobacco and nicotine products (NGP) are now widely used.
Sindy Giebe, Anja Hofmann, Melanie Brux, Frazer Lowe, Damien Breheny, Henning Morawietz, Coy Brunssen   +6 more
doaj   +1 more source

Effects of PCSK9 Targeting: Alleviating Oxidation, Inflammation, and Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Characterized as a chronic inflammatory disease of the large arteries, atherosclerosis is the primary cause of cardiovascular disease, the leading contributor of morbidity and mortality worldwide.
Emily Punch, Justus Klein, Patrick Diaba‐Nuhoho, Henning Morawietz, Mahdi Garelnabi   +4 more
doaj   +1 more source

The aging endothelium

Vascular Biology, 2021
Cellular senescence is now recognized as one of the hallmarks of aging. Herein, we examine current findings on senescence of the vascular endothelium and its impacts on age-related vascular diseases.
Ka Ka Ting, Paul Coleman, Yang Zhao, Mathew A Vadas, Jennifer R Gamble   +4 more
doaj   +1 more source

The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection

Critical Care, 2020
In severe SARS-CoV-2 infections, emerging data including recent histopathological studies have emphasized the crucial role of endothelial cells (ECs) in vascular dysfunction, immunothrombosis, and inflammation.
S. Pons, S. Fodil, É. Azoulay, L. Zafrani   +3 more
semanticscholar   +1 more source

Mimicking the Nitric Oxide‐Releasing and Glycocalyx Functions of Endothelium on Vascular Stent Surfaces

Advancement of science, 2020
Endothelium can secrete vasoactive mediators and produce specific extracellular matrix, which contribute jointly to the thromboresistance and regulation of vascular cell behaviors.
Nan Lyu, Zeyu Du, Hua Qiu, Pengyu Gao, Qin Yao, Kaiqin Xiong, Qiufen Tu, Xiangyang Li, Binghai Chen, Miao Wang, G. Pan, N. Huang, Zhilu Yang   +12 more
semanticscholar   +1 more source

YAP and the RhoC regulator ARHGAP18, are required to mediate flow-dependent endothelial cell alignment

Cell Communication and Signaling, 2020
Background Vascular endothelial cell alignment in the direction of flow is an adaptive response that protects against aortic diseases such as atherosclerosis. The RhoGTPases are known to regulate this alignment.
Paul R. Coleman, Angelina J. Lay, Ka Ka Ting, Yang Zhao, Jia Li, Sorour Jarrah, Mathew A. Vadas, Jennifer R. Gamble   +7 more
doaj   +1 more source

Reproducibility and research integrity: the role of scientists and institutions

BMC Research Notes, 2021
Reproducibility and research integrity are essential tenets of every scientific study and discovery. They serve as proof that an established and documented work can be verified, repeated, and reproduced.
Patrick Diaba-Nuhoho, Michael Amponsah-Offeh   +1 more
doaj   +1 more source

The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin - SCL/TAL1-CD44 axis. [PDF]

, 2020
The endosteal bone marrow niche and vascular endothelial cells provide sanctuaries for leukemic cells. In murine chronic myeloid leukemia (CML) CD44 on leukemia cells and E-selectin on bone marrow endothelium are essential mediators for the engraftment ...
Aggoune, D., Godavarthy, P., Hayduk, N., Herkt, S., Krause, D., Kumar, R., Lausen, J., Lucas, T., Manavski, Y., Müller, M., Oehler, V., Oellerich, T., Pan, K., Pereira, R., Saussele, S., Voutsinas, J., Weissenberger, E., Wu, Q.   +17 more
core   +2 more sources

Oxidative Stress, Antioxidants and Hypertension

Antioxidants, 2023
As a major cause of morbidity and mortality globally, hypertension remains a serious threat to global public health. Despite the availability of many antihypertensive medications, several hypertensive individuals are resistant to standard treatments, and
Michael Amponsah-Offeh, Patrick Diaba-Nuhoho, Stephan Speier, Henning Morawietz   +3 more
doaj   +1 more source

Transient receptor potential canonical type 3 channels control the vascular contractility of mouse mesenteric arteries [PDF]

, 2014
Transient receptor potential canonical type 3 (TRPC3) channels are non-selective cation channels and regulate intracellular Ca2+ concentration. We examined the role of TRPC3 channels in agonist-, membrane depolarization (high K+)-, and mechanical ...
Abramowitz, Joel, Birnbaumer, Lutz, Kim, Joo Young, Lee, Young-Ho, Muallem, Shmuel, Yeon, Dong-Soo, Yeon, Soo-In   +6 more
core   +8 more sources