Journal of Pharmacological Sciences, 2011 .: Endothelium regulates vascular tone via release of endothelium-derived relaxing factors (EDRF) including nitric oxide (NO), prostaglandin I2 (PGI2), and endothelium-derived hyperpolarizing factor (EDHF).
Xin Jin +6 more
doaj +1 more source
Particulate Matter Exposure Impairs Systemic Microvascular Endothelium-Dependent Dilation [PDF]
, 2004 Acute exposure to airborne pollutants, such as solid particulate matter (PM), increases the risk of cardiovascular dysfunction, but the mechanisms by which PM evokes systemic effects remain to be identified.
Barger, Mark +4 more
core +3 more sources
Endothelium-Derived Relaxing Factor–Mediated Vasodilation in Mouse Mesenteric Vascular Beds
Journal of Pharmacological Sciences, 2012 The endothelium in rat mesenteric vascular beds has been demonstrated to regulate vascular tone by releasing mainly endothelium-derived hyperpolarizing factor (EDHF), which is involved in the activation of K+ channels and gap-junctions.
Hiroki Fujiwara +7 more
doaj +1 more source
The role of atrial natriuretic peptide to attenuate inflammation in a mouse skin wound and individually perfused rat mesenteric microvessels. [PDF]
, 2016 We tested the hypothesis that the anti-inflammatory actions of atrial natriuretic peptide (ANP) result from the modulation of leukocyte adhesion to inflamed endothelium and not solely ANP ligation of endothelial receptors to stabilize endothelial barrier
Adamson, Roger H +5 more
core +2 more sources
Contribution of Oxidative Stress to Endothelial Dysfunction in Hypertension
Frontiers in Physiology, 2012 Endothelial dysfunction is the hallmark of hypertension, which is a multifactorial disorder. In the cardiovascular system reactive oxygen species play a pivotal role in controlling the endothelial function and vascular tone.
Bruno Rodrigues Silva +2 more
doaj +1 more source
Organ-Specific Endothelial Dysfunction Following Total Body Irradiation Exposure
Toxics, 2022 As the single cell lining of the heart and all blood vessels, the vascular endothelium serves a critical role in maintaining homeostasis via control of vascular tone, immune cell recruitment, and macromolecular transit.
Guru Prasad Sharma, Heather A. Himburg
doaj +1 more source
FOXO1 couples metabolic activity and growth state in the vascular endothelium
Nature, 2015 Endothelial cells (ECs) are plastic cells that can switch between growth states with different bioenergetic and biosynthetic requirements. Although quiescent in most healthy tissues, ECs divide and migrate rapidly upon proangiogenic stimulation ...
K. Wilhelm +17 more
semanticscholar +1 more source
Nature Cell Biology, 2015 The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) will depend on the accurate recapitulation of embryonic haematopoiesis.
Andrea Ditadi +14 more
semanticscholar +1 more source
Molecular mechanisms regulating perivascular adipose tissue - potential pharmacological targets? [PDF]
, 2017 No abstract ...
Kennedy, Simon, Salt, Ian P.
core +1 more source
Hydrogen Peroxide Is an Endothelium-Derived Hyperpolarizing Factor in Animals and Humans
Journal of Pharmacological Sciences, 2003 Vascular endothelium plays an important role in maintaining vascular homeostasis by synthesizing and releasing several vasodilating factors, such as prostacyclin, nitric oxide (NO), and a yet unidentified endothelium-derived hyperpolarizing factor (EDHF).
Matoba Tetsuya, Hiroaki Shimokawa
doaj +1 more source