Results 41 to 50 of about 519,199 (308)

Controlled rotation mechanism of DNA strand exchange by the Hin serine recombinase. [PDF]

, 2016
DNA strand exchange by serine recombinases has been proposed to occur by a large-scale rotation of halves of the recombinase tetramer. Here we provide the first direct physical evidence for the subunit rotation mechanism for the Hin serine invertase ...
Johnson, Reid C, Lei, Xianbin, Marko, John F, McLean, Meghan M, Xiao, Botao   +4 more
core   +1 more source

Differential Requirement of Cd8 Enhancers E8I and E8VI in Cytotoxic Lineage T Cells and in Intestinal Intraepithelial Lymphocytes

Frontiers in Immunology, 2019
CD8 expression in T lymphocytes is tightly regulated by the activity of at least six Cd8 enhancers (E8I-E8VI), however their complex developmental stage-, subset-, and lineage-specific interplays are incompletely understood.
Alexandra Franziska Gülich, Teresa Preglej, Patricia Hamminger, Marlis Alteneder, Caroline Tizian, Maria Jonah Orola, Sawako Muroi, Ichiro Taniuchi, Wilfried Ellmeier, Shinya Sakaguchi   +9 more
doaj   +1 more source

Targeted screening of genetic associations with COVID-19 susceptibility and severity

Frontiers in Genetics, 2022
The COVID-19 pandemic has resulted in great morbidity and mortality worldwide and human genetic factors have been implicated in the susceptibility and severity of COVID-19.
Ping Li, Yuehua Ke, Wenlong Shen, Shu Shi, Yahao Wang, Kailin Lin, Xinjie Guo, Changjun Wang, Yan Zhang, Zhihu Zhao   +9 more
doaj   +1 more source

Multiple interfaces between a serine recombinase and an enhancer control site-specific DNA inversion. [PDF]

, 2013
Serine recombinases are often tightly controlled by elaborate, topologically-defined, nucleoprotein complexes. Hin is a member of the DNA invertase subclass of serine recombinases that are regulated by a remote recombinational enhancer element containing
Chang, Yong, Dhar, Gautam, Heiss, John K, Johnson, Reid C, McLean, Meghan M   +4 more
core   +1 more source

eRNA profiling uncovers the enhancer landscape of oesophageal adenocarcinoma and reveals new deregulated pathways

eLife, 2023
Cancer is driven by both genetic and epigenetic changes that impact on gene expression profiles and the resulting tumourigenic phenotype. Enhancers are transcriptional regulatory elements that are key to our understanding of how this rewiring of gene ...
Ibrahim Ahmed, Shen-Hsi Yang, Samuel Ogden, Wei Zhang, Yaoyong Li, The OCCAMs consortium, Andrew D Sharrocks   +6 more
doaj   +1 more source

Creating New β-Globin-Expressing Lentiviral Vectors by High-Resolution Mapping of Locus Control Region Enhancer Sequences. [PDF]

, 2020
Hematopoietic stem cell gene therapy is a promising approach for treating disorders of the hematopoietic system. Identifying combinations of cis-regulatory elements that do not impede packaging or transduction efficiency when included in lentiviral ...
Aleshe, Bamidele, Ayoub, Paul George, Brown, Devin, Hollis, Roger P, Kohn, Donald B, Kurita, Ryo, Lathrop, Lindsay, Ma, Feiyang, Morgan, Richard A, Nakamura, Yukio, Pellegrini, Matteo, Senadheera, Shantha, Tam, Curtis, Unti, Mildred J, Wong, Ryan L   +14 more
core   +1 more source

REDfly: An Integrated Knowledgebase for Insect Regulatory Genomics

Insects, 2022
We provide here an updated description of the REDfly (Regulatory Element Database for Fly) database of transcriptional regulatory elements, a unique resource that provides regulatory annotation for the genome of Drosophila and other insects.
Soile V. E. Keränen, Angel Villahoz-Baleta, Andrew E. Bruno, Marc S. Halfon   +3 more
doaj   +1 more source

Reporter constructs with low background activity utilizing the cat gene [PDF]

, 1992
Reporter plasmids utilizing the cat gene for the analysis of promoter and enhancer sequences in vertebrate cells, were constructed. These plasmids minimize the background of transcription derived from cryptic promoters or cryptic regulatory elements ...
Andrea Schmidt, Boshart, Bruno Luckow, Buchman, Günther Schütz, Heard, Luckow, Michael Boshart, Michael Klüppel, Ruppert, Schüle, Seamon   +11 more
core   +1 more source

HUBUNGAN POLA KONSUMSI SUMBER ZAT BESI, INHIBITOR DAN ENHANCER ZAT BESI DENGAN KEJADIAN ANEMIA PADA SANTRIWATI PONDOK PESANTREN AL-MIZAN MUHAMMADIYAH LAMONGAN
Correlation between consumption patterns of iron sources, iron inhibitor, and iron enhancer, with the occurence of anemia among female students in Islamic Boarding School Al-Mizan Muhammadiyah Lamongan

Media Gizi Indonesia, 2022
Anemia merupakan salah satu permasalahan defisiensi zat gizi yang rentan dialami oleh remaja putri. Anemia adalah kondisi dimana kadar hemoglobin (Hb) lebih rendah dari 12 g/dL. Anemia dapat disebabkan karena kekurangan darah, penyakit infeksi, rendahnya
Fanti Septia Nabilla, Lailatul Muniroh, Mahmud Aditya Rifqi   +2 more
doaj   +1 more source

MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1 [PDF]

, 2016
Congenital heart defects are the most common birth defects in humans, and those that affect the proper alignment of the outflow tracts and septation of the ventricles are a highly significant cause of morbidity and mortality in infants.
Barnes, Ralston M., Black, Brian L., Harris, Ian S., Jaehnig, E., McCulley, David J., Norris, Russell A., Rojas González, Anabel, Sauls, Kimberly, Schachterle, William, Sinha, Tanvi   +9 more
core   +1 more source