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Multiple interfaces between a serine recombinase and an enhancer control site-specific DNA inversion. [PDF]
Serine recombinases are often tightly controlled by elaborate, topologically-defined, nucleoprotein complexes. Hin is a member of the DNA invertase subclass of serine recombinases that are regulated by a remote recombinational enhancer element containing
Chang, Yong+4 more
core +1 more source
Transcriptional control by enhancers and enhancer RNAs [PDF]
The regulation of gene expression is a fundamental cellular process and its misregulation is a key component of disease. Enhancers are one of the most salient regulatory elements in the genome and help orchestrate proper spatiotemporal gene expression during development, in homeostasis, and in response to signaling.
Michael W. Lewis+2 more
openaire +3 more sources
Functional Evolution of a cis-Regulatory Module [PDF]
Lack of knowledge about how regulatory regions evolve in relation to their structure–function may limit the utility of comparative sequence analysis in deciphering cis-regulatory sequences.
Alekseeva, Elena+5 more
core +4 more sources
Enhancers, enhancers – from their discovery to today’s universe of transcription enhancers [PDF]
AbstractTranscriptional enhancers are short (200–1500 base pairs) DNA segments that are able to dramatically boost transcription from the promoter of a target gene. Originally discovered in simian virus 40 (SV40), a small DNA virus, transcription enhancers were soon also found in immunoglobulin genes and other cellular genes as key determinants of cell-
openaire +4 more sources
Abstract On a complex manifold, the Riemann–Hilbert correspondence embeds the triangulated category of (not necessarily regular) holonomic 𝒟 {\mathcal{D}}
D'AGNOLO, ANDREA, Kashiwara, Masaki
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Mapping the Shh long-range regulatory domain [PDF]
Coordinated gene expression controlled by long-distance enhancers is orchestrated by DNA regulatory sequences involving transcription factors and layers of control mechanisms.
Amano+41 more
core +2 more sources
The Theory of Enhancement is a detailed theoretical research that presents the creative framework of the environment. It accounts for the formation of the universe taking into consideration all the laws and forces involved. The thread of this is the mathematical account of the enhancement of the nucleus.
openaire +2 more sources
It is sometimes claimed that those who succeed with the aid of enhancement technologies deserve the rewards associated with their success less, other things being equal, than those who succeed without the aid of such technologies. This claim captures some widely held intuitions, has been implicitly endorsed by participants in social–psychological ...
openaire +4 more sources
Anemia merupakan salah satu permasalahan defisiensi zat gizi yang rentan dialami oleh remaja putri. Anemia adalah kondisi dimana kadar hemoglobin (Hb) lebih rendah dari 12 g/dL. Anemia dapat disebabkan karena kekurangan darah, penyakit infeksi, rendahnya
Fanti Septia Nabilla+2 more
doaj +1 more source
The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2 [PDF]
The gene encoding interleukin-2 (IL-2) contains a sequence 52 to 326 nucleotides upstream of its transcriptional initiation site that promotes transcription in T cells that have been activated by costimulation with tetradecanoyl phorbol myristyl acetate (
Baltimore, David+3 more
core +2 more sources