Results 11 to 20 of about 9,920,783 (328)

Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation. [PDF]

Mol Cell, 2021
The mechanistic understanding of nascent RNAs in transcriptional control remains limited. Here, by a high sensitivity method methylation-inscribed nascent transcripts sequencing (MINT-seq), we characterized the landscapes of N6-methyladenosine (m6A) on ...
Lee JH, Wang R, Xiong F, Krakowiak J, Liao Z, Nguyen PT, Moroz-Omori EV, Shao J, Zhu X, Bolt MJ, Wu H, Singh PK, Bi M, Shi CJ, Jamal N, Li G, Mistry R, Jung SY, Tsai KL, Ferreon JC, Stossi F, Caflisch A, Liu Z, Mancini MA, Li W.   +24 more
europepmc   +4 more sources

Enhancer-derived RNA: A Primer

Genomics, Proteomics & Bioinformatics, 2017
Enhancer-derived RNAs (eRNAs) are a group of RNAs transcribed by RNA polymerase II from the domain of transcription enhancers, a major type of cis-regulatory elements in the genome.
Feng Liu
doaj   +3 more sources

DCP1A is an unfavorable prognostic-related enhancer RNA in hepatocellular carcinoma. [PDF]

Aging (Albany NY), 2021
Long non-coding RNAs (lncRNAs) are associated with occurrence and development of tumors. Enhancer RNA (eRNA) is a special type of lncRNAs produced from transcription of enhancer elements.
Wu H, Zhang J, Bai Y, Zhang S, Zhang Z, Tong W, Han P, Fu B, Zhang Y, Shen Z.   +9 more
europepmc   +2 more sources

Application Strategies of Super-Enhancer RNA in Cardiovascular Diseases [PDF]

Biomedicines
Cardiovascular diseases (CVDs) are a leading cause of death worldwide, and new therapeutic strategies are urgently needed. In recent years, enhancer RNAs (eRNAs) have gradually attracted attention because they offer new directions for the treatment of ...
Yi He, Yuwei Cai, Yanyan Cao, Yan Wang, Jing Wang, Hu Ding   +5 more
doaj   +2 more sources

A High-Resolution Map of Human Enhancer RNA Loci Characterizes Super-enhancer Activities in Cancer.

Cancer Cell, 2020
Although enhancers play critical roles in cancer, quantifying enhancer activities in clinical samples remains challenging, especially for super-enhancers.
Han Chen, Han Liang
semanticscholar   +3 more sources

A Muscle-Specific Enhancer RNA Mediates Cohesin Recruitment and Regulates Transcription In trans.

Molecular Cell, 2018
The enhancer regions of the myogenic master regulator MyoD give rise to at least two enhancer RNAs. Core enhancer eRNA (CEeRNA) regulates transcription of the adjacent MyoD gene, whereas DRReRNA affects expression of Myogenin in trans.
Pei-Fang Tsai, Stefania Dell’Orso, Joseph Rodriguez, Karinna O. Vivanco, K. Ko, Kan Jiang, Aster H. Juan, A. Sarshad, Laura Vian, Michelle D Tran, Darawalee Wangsa, A. H. Wang, Jelena Perovanovic, D. Anastasakis, E. Ralston, T. Ried, Hong-Wei Sun, M. Hafner, D. Larson, V. Sartorelli   +19 more
semanticscholar   +3 more sources

An enhancer RNA recruits KMT2A to regulate transcription of Myb [PDF]

Cell Reports
Summary: The Myb proto-oncogene encodes the transcription factor c-MYB, which is critical for hematopoiesis. Distant enhancers of Myb form a hub of interactions with the Myb promoter.
Juhyun Kim, Luis F. Diaz, Matthew J. Miller, Benjamin Leadem, Ivan Krivega, Ann Dean   +5 more
doaj   +2 more sources

Lingering Questions about Enhancer RNA and Enhancer Transcription-Coupled Genomic Instability. [PDF]

Trends in Genetics, 2017
Intergenic and intragenic enhancers found inside topologically associated regulatory domains (TADs) express noncoding RNAs, known as enhancer RNAs (eRNAs). Recent studies have indicated these eRNAs play a role in gene regulatory networks by controlling promoter and enhancer interactions and topology of higher-order chromatin structure. Misregulation of
Gerson Rothschild, Uttiya Basu
semanticscholar   +5 more sources

The enhancer RNA lnc-SLC4A1-1 epigenetically regulates unexplained recurrent pregnancy loss (URPL) by activating CXCL8 and NF-kB pathway

EBioMedicine, 2018
Background Enhancer RNAs (eRNAs) are a group of lncRNAs transcribed from enhancers, whose regulatory effects on gene expression are an emerging area of interest.
Zhenyao Huang, Guizhen Du, Xiaomin Huang, Li Han, Xiumei Han, Bo Xu, Yan Zhang, Mingming Yu, Yufeng Qin, Yankai Xia, Xinru Wang, Chuncheng Lu   +11 more
semanticscholar   +3 more sources

The oncofetal RNA-binding protein IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression in cancer

Nucleic Acids Research, 2020
The IGF2 mRNA-binding protein 1 (IGF2BP1) is a non-catalytic post-transcriptional enhancer of tumor growth upregulated and associated with adverse prognosis in solid cancers. However, conserved effector pathway(s) and the feasibility of targeting IGF2BP1
Simon Müller, N. Bley, Bianca Busch, Markus Glaß, M. Lederer, Claudia Misiak, Tommy Fuchs, Alice Wedler, Jacob Haase, Jean B. Bertoldo, P. Michl, S. Hüttelmaier   +11 more
semanticscholar   +3 more sources