Results 41 to 50 of about 9,920,783 (328)
Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture
Nature Communications, 2020 Enhancer RNAs are transcribed bidirectionally from core transcription initiation regions. Here, by employing nascent RNA sequencing, the authors identify quantitative trait loci (QTLs) associated with enhancer RNA level and directionality, revealing the ...
Katla Kristjánsdóttir +3 more
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Reversible 2′-OH acylation enhances RNA stability
Nature Chemistry, 2022 Abstract Stabilization of RNAs for storage, transport, and biological application remains a serious challenge, particularly for larger RNAs that are not accessible by chemical synthesis. Here, we present reversible 2’-OH acylation as a general strategy to preserve RNA of any length or origin. High-yield polyacylation of 2’-hydroxyls (“cloaking”)
Linglan Fang +4 more
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The Super-Enhancer-Derived alncRNA-EC7/Bloodlinc Potentiates Red Blood Cell Development in trans
Cell Reports, 2017 Summary: Enhancer-derived RNAs are thought to act locally by contributing to their parent enhancer function. Whether large domains of clustered enhancers (super-enhancers) also produce cis-acting RNAs, however, remains unclear.
Juan R. Alvarez-Dominguez +3 more
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Chromatin accessibility underlies synthetic lethality of SWI/SNF subunits in ARID1A-mutant cancers. [PDF]
, 2017 ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is frequently mutated in cancer. Deficiency in its homolog ARID1B is synthetically lethal with ARID1A mutation.
Amaral, Maria Luisa +5 more
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Enhancer RNAs and regulated transcriptional programs [PDF]
Trends in Biochemical Sciences, 2014 A large portion of the human genome is transcribed into RNAs without known protein-coding functions, far outnumbering coding transcription units. Extensive studies of long noncoding RNAs (lncRNAs) have clearly demonstrated that they can play critical roles in regulating gene expression, development, and diseases, acting both as transcriptional ...
Lam, Michael TY +3 more
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Tissue-specific RNA expression marks distant-acting developmental enhancers. [PDF]
PLoS Genetics, 2014 Short non-coding transcripts can be transcribed from distant-acting transcriptional enhancer loci, but the prevalence of such enhancer RNAs (eRNAs) within the transcriptome, and the association of eRNA expression with tissue-specific enhancer activity in
Han Wu +7 more
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Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis.
Cell, 2017 Hiroshi I. Suzuki, R. Young, P. Sharp
semanticscholar +3 more sources
Long non-coding RNAs and enhancers [PDF]
Current Opinion in Genetics & Development, 2011 Long non-coding RNAs (ncRNAs) are emerging as important regulatory factors in mammalian genomics. A number of reports within the last 2 years have identified thousands of actively expressed long ncRNA transcripts with distinct properties. The long ncRNAs show differential expression patterns and regulation in a wide variety of cells and tissues, adding
Ulf Andersson, Ørom, Ramin, Shiekhattar
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Enhancing cardiac reprogramming via synthetic RNA oligonucleotides [PDF]
Molecular Therapy - Nucleic Acids, 2021 Reprogramming scar fibroblasts into new heart muscle cells has the potential to restore function to the injured heart. However, the effectiveness of reprogramming is notably low. We have recently demonstrated that the effectiveness of reprogramming fibroblasts into heart muscle cells (cardiomyocytes) is increased by the addition of RNA-sensing receptor
Jiabiao Hu +5 more
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Nascent RNA sequencing analysis provides insights into enhancer-mediated gene regulation
BMC Genomics, 2018 Background Enhancers are distal cis-regulatory elements that control gene expression. Despite an increasing appreciation of the importance of enhancers in cellular function and disease, our knowledge of enhancer-regulated transcription is very limited ...
Jing Wang +5 more
doaj +1 more source