Results 71 to 80 of about 9,920,783 (328)
Enhancer of RNA polymerase III gene transcription [PDF]
Nucleic Acids Research, 1999 A protein responsible for enhanced transcription by RNA polymerase III was identified in extracts from Xenopus oocytes. This protein, called EP3, interacts with a specific DNA sequence adjacent to the 3'-end of a Xenopus somatic 5S RNA gene and forms a distinct band shift complex with a unique DNase I footprint. Enhanced transcription was observed from
Sturges, Michael R. +2 more
openaire +3 more sources
Frontiers in Molecular Biosciences, 2020 Enhancers are cis-acting elements that can promote the expression of target genes and respond to estrogen to induce the transcription of eRNAs, which are closely associated with cancer development.
Wenan Che +4 more
semanticscholar +1 more source
Evidence for additive and synergistic action of mammalian enhancers during cell fate determination
eLife, 2021 Enhancer activity drives cell differentiation and cell fate determination, but it remains unclear how enhancers cooperate during these processes.
Jinmi Choi +7 more
doaj +1 more source
Biological Psychiatry, 2019 BACKGROUND Adolescent intermittent ethanol (AIE) exposure is an emerging risk factor for adult psychopathology, such as anxiety disorders. Enhancer RNAs (eRNAs) are short noncoding RNAs transcribed from enhancer regions that regulate synaptic plasticity ...
Evan J. Kyzar, Huaibo Zhang, S. Pandey
semanticscholar +1 more source
Enhancing Chemotherapy by RNA Interference
BIO Integration, 2020 Abstract Small interfering RNA (siRNA) has shown tremendous potential for treating human diseases in the past decades. siRNA can selectively silence a pathological pathway through the targeting and degradation of a specific mRNA, significantly reducing the off-target side effects of anticancer drugs.
Shuwen Cao +5 more
openaire +2 more sources
The RNA Polymerase II Core Promoter in Drosophila. [PDF]
, 2019 Transcription by RNA polymerase II initiates at the core promoter, which is sometimes referred to as the "gateway to transcription." Here, we describe the properties of the RNA polymerase II core promoter in Drosophila The core promoter is at a strategic
Kadonaga, James T +2 more
core +1 more source
Extinction of tyrosine aminotransferase gene activity in somatic cell hybrids involves modification and loss of several essential transcription factors [PDF]
, 1993 Extinction is defined as the loss of cell type-specific gene expression that occurs in somatic cell hybrids derived by fusion of cells with dissimilar phenotypes.
Boshart, Michael +2 more
core +1 more source
Keratinocyte differentiation-dependent human papillomavirus gene regulation [PDF]
, 2017 Human papillomaviruses (HPVs) cause diseases ranging from benign warts to invasive cancers. HPVs infect epithelial cells and their replication cycle is tightly linked with the differentiation process of the infected keratinocyte.
Graham, Sheila V.
core +1 more source
Nature Communications, 2019 Emerging evidence supports roles of enhancer RNAs (eRNAs) in regulating target gene. Here, we study eRNA regulation and function during skeletal myoblast differentiation.
Yu Zhao +10 more
semanticscholar +1 more source
Enhancer RNAs: Insights Into Their Biological Role [PDF]
Epigenetics Insights, 2019 Enhancers play a central role in the transcriptional regulation of metazoans. Almost a decade ago, the discovery of their pervasive transcription into noncoding RNAs, termed enhancer RNAs (eRNAs), opened a whole new field of study. The presence of eRNAs correlates with enhancer activity; however, whether they act as functional molecules remains ...
de Lara, Josué Cortés-Fernández +2 more
openaire +2 more sources