Results 81 to 90 of about 9,920,783 (328)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

In Vivo Characterization of Linc-p21 Reveals Functional cis-Regulatory DNA Elements

Cell Reports, 2016
The Linc-p21 locus, encoding a long non-coding RNA, plays an important role in p53 signaling, cell-cycle regulation, and tumor suppression. However, despite extensive study, confusion exists regarding its mechanism of action: is activity driven by the ...
Abigail F. Groff, Diana B. Sanchez-Gomez, Marcela M.L. Soruco, Chiara Gerhardinger, A. Rasim Barutcu, Eric Li, Lara Elcavage, Olivia Plana, Lluvia V. Sanchez, James C. Lee, Martin Sauvageau, John L. Rinn   +11 more
doaj   +1 more source

The lncRNA HOTAIR transcription is controlled by HNF4α-induced chromatin topology modulation [PDF]

, 2018
The expression of the long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is largely deregulated in epithelial cancers and positively correlates with poor prognosis and progression of hepatocellular carcinoma and gastrointestinal cancers.
A Busanello, AL Cattin, AM Cozzolino, C Battistelli, C Battistelli, C Battistelli, C Cicchini, C Cicchini, C Cicchini, C Padua Alves, Carla Cicchini, Cecilia Battistelli, Claudia Montaldo, DW Dodd, E Bolotin, F Garibaldi, F Parviz, Frank J. Gonzalez, Giovanna Sabarese, H Hagege, J Dekker, JA Bonzo, JL Rinn, K Kim, L Amicone, L Santangelo, Laura Santangelo, M Darsigny, MA Battle, Marco Tripodi, MC Tsai, MJ Milevskiy, N Skrypek, NL Lazarevich, R Kogo, RA Gupta, RE Hewitt, S Holwerda, S Satohisa, S Sekiya, SH Ahn, T Oshima, WD Garrison, Y Kamiyama, Y Nie, Y Qiao, Y Ren, YJ Geng, Z Chen, Z Yang, ZH Wu, ZQ Wu   +51 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

Cell Reports, 2018
Summary: The RNA polymerase II-associated protein 1 (RPAP1) is conserved across metazoa and required for stem cell differentiation in plants; however, very little is known about its mechanism of action or its role in mammalian cells. Here, we report that
Cian J. Lynch, Raquel Bernad, Isabel Calvo, Sandrina Nóbrega-Pereira, Sergio Ruiz, Nuria Ibarz, Ana Martinez-Val, Osvaldo Graña-Castro, Gonzalo Gómez-López, Eduardo Andrés-León, Vladimir Espinosa Angarica, Antonio del Sol, Sagrario Ortega, Oscar Fernandez-Capetillo, Enrique Rojo, Javier Munoz, Manuel Serrano   +16 more
doaj   +1 more source

Epigenetic regulation of IFITM1 expression in lipopolysaccharide-stimulated human mesenchymal stromal cells

Stem Cell Research & Therapy, 2020
Background Toll-like receptor 4 (TLR4) ligands such as lipopolysaccharide (LPS) activate immunomodulatory functions and the migration of human mesenchymal stromal cells (hMSCs). Here, we study the migration-related gene expression of LPS-stimulated hMSCs
Sun Hwa Kim, Hae In Choi, Mi Ran Choi, Ga Yeong An, Bert Binas, Kyoung Hwa Jung, Young Gyu Chai   +6 more
doaj   +1 more source

The enhancer RNA ARIEL activates the oncogenic transcriptional program in T-cell acute lymphoblastic leukemia.

Blood, 2019
The oncogenic transcription factor TAL1 regulates the transcriptional program in T-cell acute lymphoblastic leukemia (T-ALL). ARID5B is one of critical downstream targets of TAL1 which further activates the oncogenic regulatory circuit in T-ALL cells ...
S. Tan, Wei Zhong Leong, P. C. T. Ngoc, T. Tan, F. C. Bertulfo, M. Lim, Omer An, Zhenhua Li, A. Yeoh, M. Fullwood, D. Tenen, T. Sanda   +11 more
semanticscholar   +1 more source

Elongin A associates with actively transcribed genes and modulates enhancer RNA levels with limited impact on transcription elongation rate in vivo

Journal of Biological Chemistry, 2020
Elongin A (EloA) is an essential transcription factor that stimulates the rate of RNA polymerase II (Pol II) transcription elongation in vitro. However, its role as a transcription factor in vivo has remained underexplored.
Behfar Ardehali, Manashree Damle, C. Perea-Resa, Michael D. Blower, R. Kingston   +4 more
semanticscholar   +1 more source

Integrator mediates the biogenesis of enhancer RNAs [PDF]

Nature, 2015
Integrator is a multi-subunit complex stably associated with the carboxy-terminal domain (CTD) of RNA polymerase II (RNAPII). Integrator is endowed with a core catalytic RNA endonuclease activity, which is required for the 3'-end processing of non-polyadenylated, RNAPII-dependent, uridylate-rich, small nuclear RNA genes. Here we examine the requirement
Lai, Fan, Gardini, Alessandro, Zhang, Anda, Shiekhattar, Ramin   +3 more
openaire   +2 more sources