Results 101 to 110 of about 15,501 (138)

RAPID LEUCINE‐ENKEPHALIN SYNTHESIS

International Journal of Peptide and Protein Research, 1980
Leucine‐enkephalin, a naturally occurring pentapeptide with morphine‐like activity, has been synthesized by a fragment condensation liquid phase method using 3,3,4‐trimethyl‐Δ3‐phospholene‐1,1‐dichloride as a coupling agent. The advantages of this method are discussed.
Michel Vilkas, Joëlle Saintno, Erna Vilkas   +2 more
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Monoclonal antibodies to leucine enkephalin

Biochemical and Biophysical Research Communications, 1983
Monoclonal antibodies to leucine enkephalin have been produced after fusion of mouse myeloma cells with spleen cells from hyper-immune mice. Hybrid clones 2D1 and SL1 were characterised using radioimmunoassay and an enzyme-linked immunosorbent assay. The antibody 2D1 was of low affinity and showed a maximum sensitivity of 0.1ng.
David P. Lane, J. Hughes, C.A. Jones
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ChemInform Abstract: A Heterocyclic Analog of Leucine‐Enkephalin.

ChemInform, 1987
Abstract1,2‐Diamino‐2‐methylpropane (I) reacts with methyl phenylglyoxalate (II) to produce the piperazinone (III) which is converted to the amide (Vb) and the acid (Vc) via the ester (Va).
Miller Francis P, John M. Kane, Mark W. Dudley, Carr Albert A, Edward W. Huber   +4 more
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The potentiation of spinal analgesia by leucine enkephalin

European Journal of Pharmacology, 1980
In two strains of rats, intrathecal administration of morphine and met-enkephalin was found to produce a dose-dependent analgesic effect as measured by the tail-flick assay. Prior administration of leu-enkelphalin at a dose which had no analgesic effect was found to reduce significantly the analgesic ED50 of both morphine and met-enkephalin.
A. E. Takemori, Jeffrey L. Vaught, Alice A. Larson   +2 more
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Multi-stage tandem mass spectrometry of metal cationized leucine enkephalin and leucine enkephalin amide

Rapid Communications in Mass Spectrometry, 2002
AbstractWe have examined the multi‐stage collision induced dissociation (CID) of metal cationized leucine enkephalin, leucine enkephalin amide, and the N‐acetylated versions of the peptides using ion trap mass spectrometry. In accord with earlier studies, the most prominent species observed during the multi‐stage CID of alkali metal cationized leucine ...
Barr, J. M., Van Stipdonk, Michael J.
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ChemInform Abstract: Leucine Enkephalin — A Mass Spectrometry Standard

ChemInform, 2011
AbstractReview: 128 refs.
Sztáray, Judit, Memboeuf, Antony, Drahos, László, Vékey, Károly   +3 more
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Plasma Methionine-Enkephalin and Leucine-Enkephalin in Normal Subjects and Patients with Pheochromocytoma*

The Journal of Clinical Endocrinology & Metabolism, 1983
Plasma methionine-enkephalin-like and leucine-enkephalin-like immunoreactivity (met-enkephalin-LI and leu-enkephalin-LI, respectively) in six normal subjects and six patients with pheochromocytoma were determined. The contents of met-enkephalin-LI and leu-enkephalin-LI in two of six pheochromocytomas were 40- to 50-fold higher and those in the other ...
Yoshio Ikeda, Makoto Sakamoto, Takaaki Yoshimasa, Kazuwa Nakao, Shozo Li, Mitsuaki Suda, Hiroo Imura   +6 more
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Hydrolysis of Peripheral Leucine Enkephalin in Allergic Asthma

Clinical Immunology, 1999
Plasma hydrolysis of leucine enkephalin was studied in a group of patients affected by seasonal allergic asthma in acute and quiescent stage; data were compared with those obtained from a control group of healthy volunteers. Results obtained indicate a statistically significant reduction of leu-enkephalin hydrolysis in allergic subjects.
Lionello Fuso, Mario Marini, Paolo Rossi, Alessandra Urbani, L.Giorgio Roda, Bernardino Nardecchia, Marina Marzano   +6 more
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Distribution of leucine-enkephalin in bone and joint tissues

Neuropeptides, 2002
The distribution and concentration of leu-enkephalin in periosteum, cortical bone, bone marrow and synovial membrane of normal rats were analysed. Periosteum, cortical bone and bone marrow of the rat femurs were collected as well as the ankles. The distribution of leu-enkephalin was analysed by immunoelectron microscopy and the concentration of leu ...
J. Urban Lindgren, Adlan M. Elhassan, Wu Qinyang, Kjell Hultenby   +3 more
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Effect of leucine-enkephalin on interneuronal transmission of excitation

Bulletin of Experimental Biology and Medicine, 1979
In the experiments on non-anesthetized flaxedil-immobilized cats it has been shown that the injection of leucin-enkephalin (1 mg) into the lateral ventricle of the brain is followed by the inhibition of evoked potentials in the ventrolateral columns of the spinal cord and of segmental interneuronal transmission in the spinal cord as well as by the ...
Fisenko Vp, Aliautdin Rn, Chichenkov On
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