Results 121 to 130 of about 16,221 (164)
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The Journal of Clinical Endocrinology & Metabolism, 1983
Plasma methionine-enkephalin-like and leucine-enkephalin-like immunoreactivity (met-enkephalin-LI and leu-enkephalin-LI, respectively) in six normal subjects and six patients with pheochromocytoma were determined. The contents of met-enkephalin-LI and leu-enkephalin-LI in two of six pheochromocytomas were 40- to 50-fold higher and those in the other ...
T, Yoshimasa +6 more
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Plasma methionine-enkephalin-like and leucine-enkephalin-like immunoreactivity (met-enkephalin-LI and leu-enkephalin-LI, respectively) in six normal subjects and six patients with pheochromocytoma were determined. The contents of met-enkephalin-LI and leu-enkephalin-LI in two of six pheochromocytomas were 40- to 50-fold higher and those in the other ...
T, Yoshimasa +6 more
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Methionine-enkephalin and leucine-enkephalin increase interleukin-1β release in mixed glia cultures
Neuropeptides, 2002Interleukin-1 beta (IL-1 beta) is synthesized in the brain in response to LPS. Excessive IL-1 beta expression is observed in neurodegenerative diseases. The aim of this study was to evaluate the effects of methionine-enkephalin (ME) and leucine-enkephalin (LE) on the baseline and LPS-activated release of IL-1 beta in rat mixed glia cultures.
Jan, Kowalski +3 more
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Secondary ion mass spectra of the neuropeptides leucine-enkephalin and methionine-enkephalin
Biological Mass Spectrometry, 1982Positive and negative secondary ion mass spectra obtained by bombardment of thin films of leucine-enkephalin and methionine-enkephalin with a pulsed beam of Cs+ ions of energy 5–15 keV were recorded using a time-of-flight mass spectrometer. Many of the secondary ions are metastable.
J. B. Westmore, W. Ens, K. G. Standing
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Synthesis of [2,6-3H2-Tyr1]leucine-enkephalin
Journal of the Chemical Society, Perkin Transactions 1, 1990The synthesis of [2,6-3H2-Tyr1]leucine-enkephalin by the catalytic tritiation of [2,6-dibromo-Tyr1]leucine-enkephalin is described. The precursor amino acid, 2,6-dibromo-DL-tyrosine, was synthesized in three steps from 2,6-dibromo-4-methoxytoluene.
Hiroshi Hasegawa +3 more
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Intraventricular self-administration of leucine-enkephalin by laboratory rats
Life Sciences, 1982Naive laboratory rats, without pre-exposure to operant training procedures or to opioids, were shown to self-administer directly into their cerebral ventricles the endogenous opiate peptide, leucine-enkephalin. They were shown to self-administer the peptide consistently for six consecutive days with no indication of the development of tolerance.
B R, Smith, Z W, Brown, Z, Amit
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Leucine-enkephalin: Reversal of intrinsic cardiovascular stimulation by pentobarbital
European Journal of Pharmacology, 1982In the conscious, chronically instrumented dog, leucine-enkephalin ([Leu5]ENK), 35 micrograms/kg injected intravenously, increased heart rate, respiratory rate, systolic and diastolic systemic arterial pressures, mean pulmonary arterial pressure, and cardiac output. After pentobarbital-induced anesthesia, the same dose of [Leu5]ENK decreased heart rate,
G, Sander +4 more
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Determination of Methionine-Enkephalin and Leucine-Enkephalin in Human Cerebrospinal Fluid
1983Abstract Commercially available radio immunoassay kits were used to find out the concentrations of met-enkephalin and leu-enkephalin in the human concentrated CSF samples in the presence of seven proteinase inhibitors. Reference values were established for lumbar CSF. No correlation was found between total protein content and both enkephalins in CSF.
T.O. KLEINE, B. MERTEN, A. SINGH
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Neuroscience Letters, 1978
Abstract The responses of neurons to iontophoretic application of methionine-enkephalin and leucine-enkephalin were tested in the tuberal hypothalamus of the guinea-pig. Both spontaneously active and ‘silent’ units activated by glutamate were investigated. Thirty-six percent of the total population of neurons tested were inhibited by these compounds.
B, Carette, P, Poulain
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Abstract The responses of neurons to iontophoretic application of methionine-enkephalin and leucine-enkephalin were tested in the tuberal hypothalamus of the guinea-pig. Both spontaneously active and ‘silent’ units activated by glutamate were investigated. Thirty-six percent of the total population of neurons tested were inhibited by these compounds.
B, Carette, P, Poulain
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Synthesis and biological evaluation of leucine enkephalin turn mimetics
Organic & Biomolecular Chemistry, 2006A cyclic Leu-enkephalin mimetic containing a 7-membered ring, and two linear analogues, has been prepared on solid phase. In the cyclic mimetic the intramolecular (1-4) hydrogen bond found in crystalline Leu-enkephalin has been replaced by an ethylene bridge.
David, Blomberg +4 more
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Enzyme-linked immunosorbent assay for leucine and methionine enkephalins
Analytical Biochemistry, 1983An enzyme-linked immunosorbent assay for enkephalins was developed by coupling the peptides to a carrier molecule (bovine serum albumin) in order to allow the antibody-antigen reaction to take place in the solid phase. The assay was shown to be highly reproducible.
G, Zamboni, C A, Jones, J, Hughes
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