Results 121 to 130 of about 16,517 (164)
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Determination of Methionine-Enkephalin and Leucine-Enkephalin in Human Cerebrospinal Fluid
1983Abstract Commercially available radio immunoassay kits were used to find out the concentrations of met-enkephalin and leu-enkephalin in the human concentrated CSF samples in the presence of seven proteinase inhibitors. Reference values were established for lumbar CSF. No correlation was found between total protein content and both enkephalins in CSF.
T.O. KLEINE, B. MERTEN, A. SINGH
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Intraventricular self-administration of leucine-enkephalin by laboratory rats
Life Sciences, 1982Naive laboratory rats, without pre-exposure to operant training procedures or to opioids, were shown to self-administer directly into their cerebral ventricles the endogenous opiate peptide, leucine-enkephalin. They were shown to self-administer the peptide consistently for six consecutive days with no indication of the development of tolerance.
B R, Smith, Z W, Brown, Z, Amit
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The effects of methionine- and leucine-enkephalin on spinal neurones of the cat
Brain Research, 1979Extra- and intracellular recordings were obtained from physiologically identified, spinal neurones in the 6th and 7th lumbar segments of the pentobarbitone-anaesthetized cat. Microiontophoretically applied methionine- and leucine-enkephalin reversibly inhibited the spontaneous, synaptically induced, and L-glutamate-induced activity in the majority of ...
W, Zieglgänsberger, I F, Tulloch
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Leucine-enkephalin: Reversal of intrinsic cardiovascular stimulation by pentobarbital
European Journal of Pharmacology, 1982In the conscious, chronically instrumented dog, leucine-enkephalin ([Leu5]ENK), 35 micrograms/kg injected intravenously, increased heart rate, respiratory rate, systolic and diastolic systemic arterial pressures, mean pulmonary arterial pressure, and cardiac output. After pentobarbital-induced anesthesia, the same dose of [Leu5]ENK decreased heart rate,
G, Sander +4 more
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Interactions of Leucine-enkephalin with α-Adrenoceptors in the Conscious Dog
Chest, 1983Leucine-enkephalin (Leu-ENK) administered systemically to the conscious dog increases heart rate and blood pressure, a response prevented by naloxone and hence mediated by opiate receptors. Clonidine attenuates the heart rate increase without affecting the pressor response.
T D, Giles, G E, Sander
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Synthesis of leucine enkephalin derivatives: Structure-function studies
Biochemical and Biophysical Research Communications, 1977Abstract The solid phase synthesis of highly purified [Leu 5 ] enkephalin and of seven derivatives including [Ala 2 ,Leu 5 ]-, [Ser 2 ,Leu 5 ]-, [Ser 3 ,Leu 5 ]-, [Aba 2 ,Leu 5 ]-, and [des-Gly 2(3) ,Leu 5 ]enkephalins are reported, and their morphine-like activities in neuroblastoma x glioma cell homogenates were measured. Changes at the 2, 3, and 5
N S, Agarwal +4 more
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Enzyme-linked immunosorbent assay for leucine and methionine enkephalins
Analytical Biochemistry, 1983An enzyme-linked immunosorbent assay for enkephalins was developed by coupling the peptides to a carrier molecule (bovine serum albumin) in order to allow the antibody-antigen reaction to take place in the solid phase. The assay was shown to be highly reproducible.
G, Zamboni, C A, Jones, J, Hughes
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Synthesis and biological evaluation of leucine enkephalin turn mimetics
Organic & Biomolecular Chemistry, 2006A cyclic Leu-enkephalin mimetic containing a 7-membered ring, and two linear analogues, has been prepared on solid phase. In the cyclic mimetic the intramolecular (1-4) hydrogen bond found in crystalline Leu-enkephalin has been replaced by an ethylene bridge.
David, Blomberg +4 more
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Synthesis and biological activity of chloromethyl ketones of leucine enkephalin
Biochemical and Biophysical Research Communications, 1980Summary The chloromethyl ketones of leucine enkephalin and D-Ala 2 -leucine enkephalin have been synthesized and tested for biological activity in the guinea pig ileum assay. The derivatives show an increased potency in morphine-like action in comparison to the corresponding enkephalins.
J T, Pelton +4 more
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Age Increases Leucine Enkephalin Hydrolysis in Human Plasma
Gerontology, 1998<i>Background:</i> The existence of age-associated alterations in immune functions and neuropeptides capable of modulating these functions prompted us to advance the hypothesis that the degradation of plasma neuropeptides, specifically opioid peptides, may be altered by aging.
L, Bongiorno +5 more
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