Results 121 to 130 of about 15,501 (138)
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Leucine-enkephalin: Reversal of intrinsic cardiovascular stimulation by pentobarbital
European Journal of Pharmacology, 1982In the conscious, chronically instrumented dog, leucine-enkephalin ([Leu5]ENK), 35 micrograms/kg injected intravenously, increased heart rate, respiratory rate, systolic and diastolic systemic arterial pressures, mean pulmonary arterial pressure, and cardiac output. After pentobarbital-induced anesthesia, the same dose of [Leu5]ENK decreased heart rate,
David H. Coy +4 more
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Intraventricular self-administration of leucine-enkephalin by laboratory rats
Life Sciences, 1982Naive laboratory rats, without pre-exposure to operant training procedures or to opioids, were shown to self-administer directly into their cerebral ventricles the endogenous opiate peptide, leucine-enkephalin. They were shown to self-administer the peptide consistently for six consecutive days with no indication of the development of tolerance.
Z.W. Brown, Zalman Amit, Brian R. Smith
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Brain methionine- and leucine-enkephalin receptors in patients with dementia
Neuroscience Letters, 1993Brain [3H]Met- and [3H]Leu-enkephalin binding was studied in patients with Alzheimer's disease (AD) and vascular dementia (VD), and in age-matched controls. Brain areas investigated were the internal and external globus pallidus, amygdala, hippocampus and temporal cortex.
Erkki Säkö +5 more
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Synthesis of leucine enkephalin derivatives: Structure-function studies
Biochemical and Biophysical Research Communications, 1977Abstract The solid phase synthesis of highly purified [Leu 5 ] enkephalin and of seven derivatives including [Ala 2 ,Leu 5 ]-, [Ser 2 ,Leu 5 ]-, [Ser 3 ,Leu 5 ]-, [Aba 2 ,Leu 5 ]-, and [des-Gly 2(3) ,Leu 5 ]enkephalins are reported, and their morphine-like activities in neuroblastoma x glioma cell homogenates were measured. Changes at the 2, 3, and 5
Nirankar S. Agarwal +4 more
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Methionine Enkephalin, But not Leucine Enkephalin, is Excreted in Bile [PDF]
Clinical Science, 1988 M S Losowsky, Judith Thornton
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Leucine-enkephalin metabolism in brain microvessel endothelial cells
Peptides, 1994The metabolism of leucine-enkephalin was investigated in primary cultures of bovine brain microvessel endothelial cell (BMEC) monolayers. Leucine-enkephalin was hydrolyzed slowly with less than 40% of the peptide metabolized following a 5-h incubation with intact BMEC monolayers at 37 degrees C.
Suzanne E. Thompson, Kenneth L. Audus
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Totalsynthese von Leucin‐ und Methonin‐Enkephalin
Justus Liebigs Annalen der Chemie, 1977AbstractDie in ihren Strukturen aufgeklärten „endogenen Opiate”︁ wurden nach „klassischen Methoden”︁ der Peptidchemie synthetisiert. An das zunächst erhaltene geschützte Tripeptidderivat Boc‐Gly‐Gly‐L‐Phe‐OMe wurden geschütztes Tyrosin und Leucin oder Methionin mit DCC/HOBt gekuppelt.
Emanuel Pietrzik +2 more
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Synthesis and biological evaluation of leucine enkephalin turn mimetics
Organic & Biomolecular Chemistry, 2006A cyclic Leu-enkephalin mimetic containing a 7-membered ring, and two linear analogues, has been prepared on solid phase. In the cyclic mimetic the intramolecular (1-4) hydrogen bond found in crystalline Leu-enkephalin has been replaced by an ethylene bridge.
Kay Brickmann +5 more
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Enzyme-linked immunosorbent assay for leucine and methionine enkephalins
Analytical Biochemistry, 1983An enzyme-linked immunosorbent assay for enkephalins was developed by coupling the peptides to a carrier molecule (bovine serum albumin) in order to allow the antibody-antigen reaction to take place in the solid phase. The assay was shown to be highly reproducible.
J. Hughes, G. Zamboni, C.A. Jones
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Age Increases Leucine Enkephalin Hydrolysis in Human Plasma
Gerontology, 1998<i>Background:</i> The existence of age-associated alterations in immune functions and neuropeptides capable of modulating these functions prompted us to advance the hypothesis that the degradation of plasma neuropeptides, specifically opioid peptides, may be altered by aging.
Spagnoli G +5 more
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