Results 101 to 110 of about 47,074 (275)

Wang-Landau molecular dynamics technique to search for low-energy conformational space of proteins

, 2007
Multicanonical molecular dynamics (MD) is a powerful technique for sampling conformations on rugged potential surfaces such as protein. However, it is notoriously difficult to estimate the multicanonical temperature effectively. Wang and Landau developed
Akira R. Kinjo, B. A. Berg, J. W. Neidigh, K. Morikami, Ken Nishikawa, P. Kollman, Takashi Mitsui, Takehiro Nagasima   +7 more
core   +1 more source

Proenkephalin A 119-159 (Penkid) Is an Early Biomarker of Septic Acute Kidney Injury: The Kidney in Sepsis and Septic Shock (Kid-SSS) Study [PDF]

, 2018
Introduction: Sepsis is the leading cause of acute kidney injury (AKI) in critically ill patients. The Kidney in Sepsis and Septic Shock (Kid-SSS) study evaluated the value of proenkephalin A 119-159 (penkid)—a sensitive biomarker of glomerular function,
Antonelli, M., Beishuizen, A., Bergmann, A., Chousterman, B. G., Constatin, J. -M., Damoisel, C., Deye, N., Di Somma, S., Dugernier, T., Francois, B., Gaudry, S., Gayat, E., Hartmann, O., Hollinger, A., Huberlant, V., Lascarrou, J. -B., Laterre, P. -F., Legrand, M., Marx, G., Mebazaa, A., Mercier, E., Oueslati, H., Pickkers, P., Sonneville, R., Struck, J., Wittebole, X.   +25 more
core   +2 more sources

Research note: Peripheral administration of Met-enkephalin: Novel attenuation of the adrenal medullary and thyroidal stress responses in young female chickens

Poultry Science
Adrenal hormones play a critical response to stresses in poultry, livestock and other vertebrates. Moreover, there are stress effects on thyroid hormones. Plasma concentrations of epinephrine (EP), norepinephrine (NE), thyroxine (T4) and triiodothyronine
Colin G. Scanes, Krystyna Pierzchala-Koziec   +1 more
doaj   +1 more source

The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential

Frontiers in Molecular Neuroscience, 2017
Temporal lobe epilepsy is considered to be one of the most common and severe forms of focal epilepsies. Patients often develop cognitive deficits and emotional blunting along the progression of the disease.
Johannes Burtscher, Christoph Schwarzer
doaj   +1 more source

UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Complex Regional Pain Syndrome

Brain and Behavior, Volume 15, Issue 9, September 2025.
Complex regional pain syndrome is a rare neuropathic pain disorder. There is a paucity of effective analgesia available for this condition. This study aimed to assess the outcomes of 64 patients prescribe cannabis‐based medicinal products for this condition up to 6 months.
Lilia Evans, Simon Erridge, Madhur Varadpande, Arushika Aggarwal, Isaac Cowley, Evonne Clarke, Katy McLachlan, Ross Coomber, James J. Rucker, Michael Platt, Mikael H. Sodergren   +10 more
wiley   +1 more source

Exosome‐Based Therapeutics: A Natural Solution to Overcoming the Blood–Brain Barrier in Neurodegenerative Diseases

MedComm, Volume 6, Issue 9, September 2025.
Therapies for neurodegenerative diseases (NDs) are constrained by the blood–brain barrier (BBB), which limits drug delivery. Exosomes, with their ability to cross BBB and deliver drugs efficiently, emerge as a promising platform for central nervous system‐targeted therapies. ABSTRACT Neurodegenerative diseases present significant therapeutic challenges,
Min Sun, Feng Qin, Qian Bu, Yue Zhao, Xiaofeng Yang, Dingwen Zhang, Xiaobo Cen   +6 more
wiley   +1 more source

Embracing Complexity: Peptides as Tunable Scaffolds in the Construction of Discrete Supramolecular Systems

Angewandte Chemie, Volume 137, Issue 34, August 18, 2025.
The inherent chirality, tunability, biocompatibility, and robustness of peptides provide an exciting opportunity for supramolecular chemistry. In this mini‐review, we explore uses of peptides in discrete supramolecular systems, how chemists can draw inspiration from larger biological assemblies, and discuss how embracing the complexity of peptide ...
Ben E. Barber, Ellen M. G. Jamieson, Leah E. M. White, Charlie T. McTernan   +3 more
wiley   +2 more sources

Lentil Flours as Sustainable Source of Proteins for the Food Industry

Sustainable Food Proteins, Volume 3, Issue 3, September 2025.
Lentils, due to their accessibility, sustainability, and high nutritional value, emerge as a promising option as protein flour for food development. This study evaluated different functional and nutritional properties of lentil flours. ABSTRACT The growing transition toward a plant‐based diet, coupled with the need for sustainable dietary protein ...
S. M. Pontoni, A.G. Garzón, G. D. Heinen, S.R. Drago   +3 more
wiley   +1 more source

Unfolding Hidden Barriers by Active Enhanced Sampling

, 2017
Collective variable (CV) or order parameter based enhanced sampling algorithms have achieved great success due to their ability to efficiently explore the rough potential energy landscapes of complex systems.
Chen, Ming, Zhang, Jing
core   +1 more source

Differential Changes in Striatal Projection Neurons in R6/2 Transgenic Mice for Huntington's Disease

Neurobiology of Disease, 2002
In early adult-onset Huntington's disease (HD), enkephalinergic striatopallidal projection neurons show preferential loss, reduced preproenkephalin (PPE) expression in surviving striatopallidal neurons, and loss of fibers in their projection target area.
Z. Sun, N. Del Mar, C. Meade, D. Goldowitz, A. Reiner   +4 more
doaj   +1 more source