Results 111 to 120 of about 42,525 (258)

ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system

British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.
G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison, Clauda Abboud, Dayana Abboud, Abdulrasheed O. Abdulrahman, Ana‐Nicoleta Bondar, Julie Dam, Zafiroula Georgoussi, Jesús Giraldo, Anemari Horvat, Christos Karoussiotis, Alba Paz‐Castro, Miriam Scarpa, Hannes Schihada, Nicole Scholz, Bilge Güvenc Tuna, Nina Vardjan   +15 more
wiley   +1 more source

Nuclear‐Magnetic‐Resonance Study on Met‐enkephalin and Met‐enkephalin [PDF]

, 1979
Tsutomu Higashijima, Jun’ichi Kobayashi, Ukon Nagai, Tatsuo Miyazawa   +3 more
openalex   +1 more source

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, Volume 182, Issue 14, Page 3249-3300, July 2025.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Effect of leucine enkephalin administration on ovarian maturation in the freshwater crab Travancoriana schirnerae

International Journal of Aquatic Biology, 2019
The current study focused on the effect of administration of the neurotransmitter leucine enkephalin on ovarian maturation in the freshwater crab Travancoriana schirnerae.
Navya Gopal, Arath Raghavan Sudha Devi
doaj   +1 more source

Multi-Overlap Simulations for Transitions between Reference Configurations

, 2003
We introduce a new procedure to construct weight factors, which flatten the probability density of the overlap with respect to some pre-defined reference configuration.
A. Mitsutake, A. Mitsutake, B. Hesselbo, B. von Freyberg, B.A. Berg, B.A. Berg, B.A. Berg, B.A. Berg, B.A. Berg, B.A. Berg, B.A. Berg, Bernd A. Berg, D. Hamada, F. Eisenmenger, F. Wang, G.M. Torrie, H. Meirovitch, Hiroshi Noguchi, K. Kuwajima, M.J. Sippl, N. Metropolis, R.A. Sayle, U.H. Hansmann, U.H. Hansmann, U.H. Hansmann, Y. Okamoto, Y. Sugita, Yuko Okamoto, Z. Li   +28 more
core   +1 more source

Asthma and enkephalin. [PDF]

BMJ, 1980
R J Butland, J. Pang, D Geddes
openaire   +3 more sources

Decoding Gastric Reflexes: The Role of Mechanosensitive Enteric Neurons in Stomach Motility

Neurogastroenterology &Motility, Volume 37, Issue 7, July 2025.
ABSTRACT This review focuses on mechanosensitive enteric neurons (MEN) in the guinea pig stomach and their roles in gastric motor reflex pathways. The guinea pig model is advantageous for studying gastric physiology, as its stomach structure and function closely resemble those of humans. Gastric motility involves distinct functional regions: the fundus
Gemma Mazzuoli‐Weber, Sophia Mayr, Kristin Elfers   +2 more
wiley   +1 more source

Enkephalin- and somatostatin-like immunoreactivities in human adrenal medulla and pheochromocytoma. [PDF]

, 1979
Jan M. Lundberg, Bertil Hamberger, Marianne Schultzberg, T Hökfelt, P. O. Granberg, Suad Efendić, Lars Terenius, Menek Goldstein, Roger L. Luft   +8 more
openalex   +1 more source

Interaction and Localization of One-electron Orbitals in an Organic Molecule: Fictitious Parameter Analysis for Multi-physics Simulations

, 2006
We present a new methodology to analyze complicated multi-physics simulations by introducing a fictitious parameter. Using the method, we study quantum mechanical aspects of an organic molecule in water.
Bies W. E., Brody T. A., Gaspard P., Hirata F., Inadomi Y., Kitaura K., Lee M.-I., Levit S., Machida M., Matsuoka S., Ogata S., Roothaan C. C. J., Sato H., Sato H., Sato T., Takami T., Takami T., Takami T., Takami T., Ten-no S., Ten-no S., Timberlake T., Yoshida N., Zakrzewski J., Zakrzewski J.   +24 more
core   +1 more source

Enteric neuromodulators and mucus discharge in a fish infected with the intestinal helminth Pomphorhynchus laevis

Parasites & Vectors, 2015
Background In vertebrates, the presence of enteric worms can induce structural changes to the alimentary canal impacting on the neuroendocrine system, altering the proper functioning of the gastrointestinal tract and affecting the occurrence and relative
Giampaolo Bosi, Andrew Paul Shinn, Luisa Giari, Bahram Sayyaf Dezfuli   +3 more
doaj   +1 more source