Results 11 to 20 of about 35,312 (157)
The role of enkephalinergic systems in substance use disorders
Frontiers in Systems Neuroscience, 2022 Enkephalin, an endogenous opioid peptide, is highly expressed in the reward pathway and may modulate neurotransmission to regulate reward-related behaviors, such as drug-taking and drug-seeking behaviors.
Lauren G. Rysztak +2 more
doaj +1 more source
A drug delivery strategy: binding enkephalin to asialoglycoprotein receptor by enzymatic galactosylation. [PDF]
PLoS ONE, 2014 Glycosylation of biopharmaceuticals can mediate cell specific delivery by targeting carbohydrate receptors. Additionally, glycosylation can improve the physico-chemical (drug-like) properties of peptide based drug candidates.
Michelle P Christie +8 more
doaj +1 more source
Increased Serum Met-enkephalin Level in Patients with Intrahepatic Cholestasis of Pregnancy
Bagcilar Medical Bulletin, 2022 Objective:To evaluate met-enkephalin levels in women with intrahepatic cholestasis of pregnancy (ICP) by comparison to healthy controls and to compare the pregnancy outcomes.Method:This cross-sectional study was conducted in 43 pregnant women with ICP ...
Sema Süzen Çaypınar, Murat Ekin
doaj +1 more source
Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals
Frontiers in Neuroscience, 2022 Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Yoshihisa Uenoyama +4 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2018 Epilepsies are a group of common neurological diseases exerting a strong burden on patients and society, often lacking clear etiology and effective therapeutical strategies.
Johannes Burtscher +10 more
doaj +1 more source
Annals of Hepatology, 2008 Endogenous opioids participate in growth regulation. Liver regeneration relates to growth. Thus, we explored the expression of methionine enkephalin and of the delta opioid receptor 1 immunoreactivities with a polyclonal rabbit antibody in deparaffinized
Vijaya D. Boyella +2 more
doaj +1 more source
Endogenous Opioids in Crohn’s Disease
Biomedicines, 2023 Caring for patients with Crohn’s disease (CD) is a serious challenge in modern medicine. The increasing incidence of CD among adolescents and the severe course of the disease create the need for new methods of diagnosis and therapy.
Adrian Martyniak +2 more
doaj +1 more source
Journal of Pharmacological Sciences, 2007 Previous in vitro studies have shown that the degradation of [Met5]enkephalin-Arg6-Phe7 during incubation with cerebral membrane preparations is largely prevented by a mixture of three peptidase inhibitors: amastatin, captopril, and phosphoramidon.
Shigeru Takahashi +5 more
doaj +1 more source
Viruses, 2021 Psychostimulant use is a major comorbidity in people living with HIV, which was initially explained by them adopting risky behaviors that facilitate HIV transmission.
María Amparo Assis +2 more
doaj +1 more source
Great Increase in Antinociceptive Potency of [Leu5]Enkephalin After Peptidase Inhibition
Journal of Pharmacological Sciences, 2008 Previous in vitro studies have shown that the degradation of [Leu5]enkephalin during incubation with cerebral membrane preparations is almost completely prevented by a mixture of three peptidase inhibitors: amastatin, captopril, and phosphoramidon.
Kazuhito Akahori +6 more
doaj +1 more source