Effects of Cholinergic and Opioid Antagonists on In Vitro Release of Met-Enkephalin, Somatostatin and Insulin-like Growth Factor-1 by and PENK Expression in Crop, Proventriculus and Duodenum of Newly Hatched Chickens. [PDF]
Animals (Basel)The gastrointestinal (GI) tract is under neural, endocrine and paracrine control. The release (basal and in the presence of either cholinergic and opioid antagonists) of Met-enkephalin, insulin-like growth factor 1 (IGF-1) and somatostatin (SRIF) was ...
Scanes CG +3 more
europepmc +2 more sources
Role of enkephalin derivative in promoting wound healing and scar remodeling via increased epidermal growth factor in a mouse model [PDF]
Archives of Aesthetic Plastic Surgery, 2023 Background Enkephalin, an endogenous neuropeptide, binds to the delta (δ) opioid receptor and exerts an antinociceptive effect. Recent studies have suggested that neuropeptides might effectuate cutaneous wound healing.
Sun Eung Kim +2 more
doaj +1 more source
Disparate Effects of Stressors on Met-Enkephalin System Parameters and on Plasma Concentrations of Corticosterone in Young Female Chickens. [PDF]
Animals (Basel)The effects of stressors were examined on Met-enkephalin-related parameters and plasma concentrations of corticosterone in 14-week-old female chickens.
Scanes CG, Pierzchala-Koziec K.
europepmc +2 more sources
Highly sensitive in vivo detection of dynamic changes in enkephalins following acute stress in mice. [PDF]
ElifeEnkephalins are opioid peptides that modulate analgesia, reward, and stress. In vivo detection of enkephalins remains difficult due to transient and low endogenous concentrations and inherent sequence similarity.
Mikati MO +8 more
europepmc +2 more sources
The role of enkephalinergic systems in substance use disorders
Frontiers in Systems Neuroscience, 2022 Enkephalin, an endogenous opioid peptide, is highly expressed in the reward pathway and may modulate neurotransmission to regulate reward-related behaviors, such as drug-taking and drug-seeking behaviors.
Lauren G. Rysztak +2 more
doaj +1 more source
A drug delivery strategy: binding enkephalin to asialoglycoprotein receptor by enzymatic galactosylation. [PDF]
PLoS ONE, 2014 Glycosylation of biopharmaceuticals can mediate cell specific delivery by targeting carbohydrate receptors. Additionally, glycosylation can improve the physico-chemical (drug-like) properties of peptide based drug candidates.
Michelle P Christie +8 more
doaj +1 more source
Disrupted circadian rhythms and opioid-mediated adverse effects: Bidirectional relationship and putative mechanisms. [PDF]
J NeuroendocrinolAbstract Recent studies have shown a link between disrupted circadian rhythms and the development of chronic opioid‐induced negative effects. Both animal and human studies show a significant bidirectional relationship between the circadian system and opioid effects.
Mehranfard N, Ghasemi M, Saboory E.
europepmc +2 more sources
Research Note: Morphine influences circulating and tissue concentrations of met-enkephalin and proenkephalin (PENK) expression and plasma concentrations of corticosterone in chickens. [PDF]
Poult Sci: The effects of the administration of the opioid agonist, morphine, on plasma and tissue concentrations of Met-enkephalin were determined in 14 wk old female chickens.
Scanes CG, Pierzchała-Koziec K.
europepmc +2 more sources
‘Acetaldehyde‐enkephalins’: elucidation of the structure of the acetaldehyde adducts of methionine‐enkephalin and leucine‐enkephalin [PDF]
FEBS Letters, 1980 The two major endogenous opioid pentapeptides, methionine-enkephalin and leucine-enkephalin [ 1,2] rapidly react with acetaldehyde, under very mild conditions, to give an ‘acetaldehyde-enkephalin’ adduct, referred to as ‘acetaldehyde-enkephalin [Met’] and ‘acetaldehyde-enkephalin [Leu”], respectively 231.
Summers, Michael C. +2 more
openaire +4 more sources
Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals
Frontiers in Neuroscience, 2022 Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Yoshihisa Uenoyama +4 more
doaj +1 more source