Results 41 to 50 of about 37,089 (225)

Acetaldehyde‐enkephalins: pronounced changes in the opiate activity of methionine‐enkephalin and leucine‐enkephalin on reaction with acetaldehyde [PDF]

FEBS Letters, 1980
We have shown that the two major endogenous opioid peptides, methionine-enkephalin and leucineenkephalin [ 1,2] (enkephalin [Met’] and enkephalin[Leu’]) rapidly react with acetaldehyde in aqueous buffers to give a stable ‘acetaldehyde-enkephalin’ adduct, referred to as ‘acetaldehyde-enkephalin[Met’]’ and ‘acetaldehyde-enkephalin [Leu’]‘, respectively ...
Summers, Michael C., Hayes, Roger J.
openaire   +2 more sources

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

The enzymatic degradation and transport of leucine–enkephalin and 4-imidazolidinone enkephalin prodrugs at the blood–brain barrier

, 1998
In this study, the stability in and transport across a cell culture model of the blood-brain barrier (BBB) is investigated for leucine-enkephalin (Leu-enkephalin) and four 4-imidazolidinone prodrugs of Leu-enkephalin. The results show that Leu-enkephalin
G.J Friis, L Lund, Bak, A., L Hovgaard, Lund, L., Friis, G.J., L.L Christrup, Christrup, Lona Louring, A Bak, Hovgaard, L.   +9 more
core   +1 more source

Disparate Effects of Stressors on Met-Enkephalin System Parameters and on Plasma Concentrations of Corticosterone in Young Female Chickens

Animals
The effects of stressors were examined on Met-enkephalin-related parameters and plasma concentrations of corticosterone in 14-week-old female chickens.
Colin Guy Scanes, Krystyna Pierzchala-Koziec   +1 more
doaj   +1 more source

Striatal Neuropeptides Enhance Selection and Rejection of Sequential Actions

Frontiers in Computational Neuroscience, 2017
The striatum is the primary input nucleus for the basal ganglia, and receives glutamatergic afferents from the cortex. Under the hypothesis that basal ganglia perform action selection, these cortical afferents encode potential “action requests.” Previous
David Buxton, Enrico Bracci, Paul G. Overton, Kevin Gurney   +3 more
doaj   +1 more source

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

British Journal of Pharmacology, EarlyView.
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton, Fraser Nunn, Erika Lace, Álvaro Lorente‐Macías, Rachel Toth, Asier Unciti‐Broceta, Tim G. Hales   +6 more
wiley   +1 more source

The role of BDNF/TrkB signaling in acute amphetamine-induced locomotor activity and opioid peptide gene expression in the rat dorsal striatum

Frontiers in Systems Neuroscience, 2011
Exposure to psychostimulants increases brain-derived neurotrophic factor (BDNF) mRNA and protein levels in the cerebral cortex and subcortical structures.
Jacqueline F McGinty, Alexandra J Bache, Nortorious T Coleman, Wei-Lun eSun   +3 more
doaj   +1 more source

Endogenous Opioid Levels Do Not Correlate With Itch Intensity and Therapeutic Interventions in Hepatic Pruritus

Frontiers in Medicine, 2021
Background: Chronic pruritus affects up to 70% of patients with immune-mediated hepatobiliary disorders. Antagonists of the μ-opioid receptor (MOR) and agonists of the κ-opioid receptor (KOR) are used to treat hepatic itch, albeit with limited success ...
Miriam M. Düll, Katharina Wolf, Marcel Vetter, Peter Dietrich, Peter Dietrich, Markus F. Neurath, Markus F. Neurath, Andreas E. Kremer   +7 more
doaj   +1 more source

THE DISTRIBUTION OF METHIONINE‐ENKEPHALIN AND LEUCINE‐ENKEPHALIN IN THE BRAIN AND PERIPHERAL TISSUES [PDF]

British Journal of Pharmacology, 1977
A method is described for the rapid extraction of opioid peptides from the brain and other tissues. The method is based on acid extraction of tissues followed by adsorption of the extract onto Amberlite XAD‐2 resin. Elution with methanol separates the enkephalins and α‐endorphin from β‐endorphin.Over 90% of the opioid peptide activity isolated from ...
J, Hughes, H W, Kosterlitz, T W, Smith
openaire   +5 more sources

The Enteric Nervous System: An Integrative Hub From Development to Systemic Physiology

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 10, Page 977-992, December 2026.
Unlike a static hardwired circuit, the ENS continuously remodels its transcriptional programs and synaptic connectivity in response to three ecological forces: microbial metabolites, immune cell signals and enteroendocrine cues. ABSTRACT The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the ...
Mario Cuchillo‐Hilario, Margarita Díaz‐Martínez, Mario Alberto Viazcan‐Carbajal, Victor David González‐Fernández   +3 more
wiley   +1 more source