Results 61 to 70 of about 37,089 (225)
Fluoxetine (Prozac) is a drug that is useful for treating depression and for studying serotonin system function in live brain tissue. Unfortunately, the use of fluoxetine tends to foul electrodes when using fast‐scan cyclic voltammetry. In this work, we evaluated an extended serotonin waveform as a useful approach for mitigating fouling by fluoxetine ...
Chase Stucky +7 more
wiley +1 more source
Neuropharmacological actions of enkephalin after systemic administration
A pentapeptide, methionine-enkephalin, which interacts with opiate receptors in the brain, was found to markedly potentiate the behavioral effects of DOPA when administered intraperitoneally into mice.
Coy, David H +5 more
core +1 more source
Abstract Refractory dissolved organic nitrogen is a major component of the ocean's nitrogen pool, yet the mechanisms producing and preserving it remain poorly understood. Here, we show that deaminated peptides (DAPs), derived from microbial processing of proteinaceous material, are ubiquitous across oxygenated marine environments—from productive ...
Pauline L. Martinot +3 more
wiley +1 more source
Inimal or no staining is seen in pancreas of () naïve and () control animals with alcohol and high-fat diet induced pancreatitis. . Met-ENK expression was significantly increased in the pancreas of HSV-ENK-treated animals fed the same diet compared to ...
Yong Ren (86476) +7 more
core +1 more source
Objective. The aim of the present study was to demonstrate the spatial relationship between the c-Fos immunoreactive cells elicited by an acute treatment with neuroleptics including amisulpride (AMI), olanzapine (OLA), quetiapine (QUE), and aripiprazole (
Kiss Alexander, Osacka Jana
doaj +1 more source
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin +6 more
wiley +1 more source
Hepatoprotective Effects of Met-enkephalin on Acetaminophen-Induced Liver Lesions in Male CBA Mice
Recent histopathological investigations in patients with hepatitis suggested possible involvement of Met-enkephalin and its receptors in the pathophysiology of hepatitis.
Roko Martinić +9 more
doaj +1 more source
Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects
Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova +2 more
wiley +1 more source
Enkephalin suppresses afferent cochlear neurotransmission.
The effects of enkephalin and naloxone, applied iontophoretically, were tested on induced firing activity of the afferent dendrites on inner hair cells in the guinea pig. Enkephalin strongly depresses the depolarizing effect of N-methyl-D-aspartate (NMDA)
Bürki C, Felix D, Ehrenberger K
core +1 more source
Adolescent binge drinking is associated with an increased risk of substance use disorder, but how ethanol affects the central levels of endogenous opioid peptides is still not thoroughly investigated.
Linnea Granholm +2 more
doaj +1 more source

