Results 61 to 70 of about 29,492 (178)

CNS Active O-Linked Glycopeptides that Penetrate the BBB

Frontiers in Chemistry, 2015
Naturally occurring glycopeptides and glycoproteins play important roles in biological processes. Glycosylation is one of the most common post-translational modifications in vivo.
Evan M Jones, Robin ePolt
doaj   +1 more source

The Connections of the Telencephalic Pallium in the White Sturgeon, Acipenser transmontanus: An Experimental Study

Journal of Comparative Neurology, Volume 534, Issue 8, August 2026.
Sturgeons are an ancient and basal group of ray‐finned fishes whose pallium consists of lateral, medial, and posterior divisions. The connections of these divisions were determined by injections of biotinylated dextran amine and DiI. Although there is considerable overlap in the connections of these pallial divisions, their heaviest connections are ...
R. Glenn Northcutt
wiley   +1 more source

Role of PBN‐CeA Circuit in Paclitaxel‐Induced Neuropathic Pain and Negative Emotions

CNS Neuroscience &Therapeutics, Volume 32, Issue 8, August 2026.
Paclitaxel‐induced neuropathy recruits the PBN–CeA pathway and increases CeA PDYN expression, contributing to pain hypersensitivity and negative emotional behaviors. Suppressing PBN inputs to the CeA or blocking KOR with Navacaprant mitigates both sensory hypersensitivity and negative emotional symptoms.
Huiqin Chen, Liang Chen, Yu Chen, Yin Huang, Fei Fan, YiQian Liu, Qianli Zhang, Ying Tang, Aiqin Chen, Chun Lin   +9 more
wiley   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, Volume 18, Issue 8, Page 1097-1113, August 2026.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

High‐Throughput Equine Plasma Profiling Using Laser‐Assisted Rapid Evaporative Ionisation Mass Spectrometry

Journal of Mass Spectrometry, Volume 61, Issue 8, August 2026.
ABSTRACT Remnants of erythrocyte removal from blood constitute therapeutic plasma—a water‐based solution containing mainly platelets, extracellular vesicles (EVs), protein and lipid complexes and ions. Plasma‐based therapies, including their use to accelerate wound healing in human and animal patients, are increasingly gaining prominence in ...
Adrienn Molnár, Matevž Arko, Kaja Troha, András Marton, Boglárka Tauber, Aleš Iglič, György Tibor Balogh, Júlia Balog, Matej Hočevar, Vesna Kadunc Kos, Saba Battelino, Veronika Kralj‐Iglič, Gitta Schlosser   +12 more
wiley   +1 more source

Effects of Restraint Stress on Circulating Corticosterone and Met Enkephalin in Chickens: Induction of Shifts in Insulin Secretion and Carbohydrate Metabolism

Animals
This study examined the effects of acute restraint stress in the presence or absence of naltrexone on the circulating concentrations of insulin, glucose, Met-enkephalin and corticosterone in 14-week-old chickens [design: 2 sex × 2 stress/non-stress × 2 +/
Colin G. Scanes, Krystyna Pierzchała-Koziec, Alina Gajewska   +2 more
doaj   +1 more source

The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential

Frontiers in Molecular Neuroscience, 2017
Temporal lobe epilepsy is considered to be one of the most common and severe forms of focal epilepsies. Patients often develop cognitive deficits and emotional blunting along the progression of the disease.
Johannes Burtscher, Christoph Schwarzer
doaj   +1 more source

Differential Changes in Striatal Projection Neurons in R6/2 Transgenic Mice for Huntington's Disease

Neurobiology of Disease, 2002
In early adult-onset Huntington's disease (HD), enkephalinergic striatopallidal projection neurons show preferential loss, reduced preproenkephalin (PPE) expression in surviving striatopallidal neurons, and loss of fibers in their projection target area.
Z. Sun, N. Del Mar, C. Meade, D. Goldowitz, A. Reiner   +4 more
doaj   +1 more source

Enteric neuromodulators and mucus discharge in a fish infected with the intestinal helminth Pomphorhynchus laevis

Parasites & Vectors, 2015
Background In vertebrates, the presence of enteric worms can induce structural changes to the alimentary canal impacting on the neuroendocrine system, altering the proper functioning of the gastrointestinal tract and affecting the occurrence and relative
Giampaolo Bosi, Andrew Paul Shinn, Luisa Giari, Bahram Sayyaf Dezfuli   +3 more
doaj   +1 more source

Enkephalins and Pain Modulation: Mechanisms of Action and Therapeutic Perspectives

Biomolecules
Enkephalins, a subclass of endogenous opioid peptides, play a pivotal role in pain modulation. Enkephalins primarily exert their effects through opioid receptors located widely throughout both the central and peripheral nervous systems.
Mario García-Domínguez
doaj   +1 more source