Results 51 to 60 of about 29,492 (178)

Hepatoprotective Effects of Met-enkephalin on Acetaminophen-Induced Liver Lesions in Male CBA Mice

Molecules, 2014
Recent histopathological investigations in patients with hepatitis suggested possible involvement of Met-enkephalin and its receptors in the pathophysiology of hepatitis.
Roko Martinić, Hrvoje Šošić, Petra Turčić, Paško Konjevoda, Aleksandra Fučić, Ranko Stojković, Gorana Aralica, Mario Gabričević, Tin Weitner, Nikola Štambuk   +9 more
doaj   +1 more source

Sex and Chronic Stress Alter the Distribution of Corticotropin‐Releasing Factor Receptor in Rat Hippocampus Following Oxycodone Conditioned Place Preference

Synapse, Volume 80, Issue 5, September 2026.
Chronic stress modifies the effect of oxycodone conditioned place preference (Oxy CPP) on corticotropin releasing factor 1 (CRFR1) subcellular distributions in hippocampal subregions. These stress‐ and oxycodone‐induced changes in CRFR1 density may influence sex differences in hippocampal learning and memory processes both at baseline and following Oxy
Dana N. Silberstein, Zoha Baig, Batsheva Rubin, Fangmin Yu, Joshua Kogan, Jason D. Gray, Yan Zhou, Teresa A. Milner   +7 more
wiley   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source

Episodic Ethanol Exposure in Adolescent Rats Causes Residual Alterations in Endogenous Opioid Peptides

Frontiers in Psychiatry, 2018
Adolescent binge drinking is associated with an increased risk of substance use disorder, but how ethanol affects the central levels of endogenous opioid peptides is still not thoroughly investigated.
Linnea Granholm, Lova Segerström, Ingrid Nylander   +2 more
doaj   +1 more source

On the History of Hepatic Vein Catheterization

Liver International, Volume 46, Issue 9, September 2026.
ABSTRACT Hepatic vein catheterization (HVC) in man was first performed 80 years ago in the wake of right‐sided heart catheterization. Several new methods, recognitions and concepts followed, especially the indirect Fick‐method for determination of splanchnic blood flow. Five years passed before pressure measurements were performed and routine HVCs were
Jens Henrik Henriksen, Flemming Bendtsen, Søren Møller   +2 more
wiley   +1 more source

Venom‐Derived Bioactive Peptides: From Toxins to Therapeutics

Advanced Therapeutics, Volume 9, Issue 8, August 2026.
Venomics → Target Identification → Peptide Optimization → Therapeutic Translation Bioactive venom peptides targeting ion channels, enzymes, and receptors drive the development of next‐generation precision therapeutics. ABSTRACT Venoms are complex biochemical mixtures composed of diverse bioactive components, including proteins, enzymes, small molecules,
Eldho Sabu, Othman Al Musaimi
wiley   +1 more source

THE DISTRIBUTION OF METHIONINE‐ENKEPHALIN AND LEUCINE‐ENKEPHALIN IN THE BRAIN AND PERIPHERAL TISSUES [PDF]

British Journal of Pharmacology, 1977
A method is described for the rapid extraction of opioid peptides from the brain and other tissues. The method is based on acid extraction of tissues followed by adsorption of the extract onto Amberlite XAD‐2 resin. Elution with methanol separates the enkephalins and α‐endorphin from β‐endorphin.Over 90% of the opioid peptide activity isolated from ...
J, Hughes, H W, Kosterlitz, T W, Smith
openaire   +5 more sources

The dopamine D1-D2 receptor heteromer in striatal medium spiny neurons: evidence for a third distinct neuronal pathway in basal ganglia

Frontiers in Neuroanatomy, 2011
Dopaminergic signaling within the basal ganglia has classically been thought to occur within two distinct neuronal pathways; the direct striatonigral pathway which contains the dopamine D1 receptor and the neuropeptides dynorphin and substance P, and the
Melissa L. Perreault, Melissa L. Perreault, Ahmed eHasbi, Ahmed eHasbi, Brian F. O'Dowd, Brian F. O'Dowd, Susan R. George, Susan R. George   +7 more
doaj   +1 more source

Interaction of the Gut Microbiota and the Enteric Nervous System: Implications in Gastrointestinal Disorders Associated With Autism Spectrum Disorder

Autism Research, Volume 19, Issue 8, August 2026.
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction, restricted interests, and repetitive behaviors. In addition to these core behavioral symptoms, gastrointestinal (GI) disorders are frequently reported, ranging from severe constipation to diarrhea.
Baptiste Ganachaud, María José Mendoza‐León, Justine Marchix, Alonso Fernandez Tello, Catherine Le Berre Scoul, Ma Cecilia Opazo, Michel Neunlist, Claudia A. Riedel, Martial Caillaud, Hélène Boudin   +9 more
wiley   +1 more source

Pinus pinea L. Periderm as a Sustainable Source of Phenolic Bioactives: Integrated Phytochemical, Antioxidant, and Elemental Investigation

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
A hydroalcoholic extract from the renewable periderm of Pinus pinea is characterized through integrated phytochemical, biological and elemental analyses. The extract exhibits a phenolic‐rich composition, significant antioxidant activity and preliminary protection against oxidative stress in SH‐SY5Y cells, while elemental profiling indicates low levels ...
Vlad Sebastian Popescu, Fabjola Bilo, Eileen Mac Sweneey, Laura Borgese, Gregorio Peron, Giulia Abate, Andrea Mastinu   +6 more
wiley   +1 more source