Results 31 to 40 of about 37,089 (225)

l-DOPA-Induced Dyskinesia in the Intrastriatal 6-Hydroxydopamine Model of Parkinson's Disease: Relation to Motor and Cellular Parameters of Nigrostriatal Function

Neurobiology of Disease, 2002
In order to assess the role of striatal dopamine (DA) afferents in l-DOPA-induced dyskinesia, we have studied a large series of rats sustaining 2, 3, or 4 unilateral injections of 6-hydroxydopamine (6-OHDA) in the lateral striatum.
Christian Winkler, Deniz Kirik, Anders Björklund, M.Angela Cenci   +3 more
doaj   +1 more source

Cocaine Reduces the Neuronal Population While Upregulating Dopamine D2-Receptor-Expressing Neurons in Brain Reward Regions: Sex-Effects

Frontiers in Pharmacology, 2021
Addiction to cocaine is associated with dysfunction of the dopamine mesocortical system including impaired dopamine-2 receptor (D2r) signaling. However, the effects of chronic cocaine on neuronal adaptations in this system have not been systematically ...
Kevin Clare, Chelsea Pan, Gloria Kim, Kicheon Park, Juan Zhao, Nora D. Volkow, Zhicheng Lin, Congwu Du   +7 more
doaj   +1 more source

Smart Polymeric Nanocarriers of Met-enkephalin

, 2016
This study describes a novel approach to polymeric nanocarriers of the therapeutic peptide met-enkephalin based on the aggregation of thermoresponsive polymers. Thermoresponsive bioconjugate poly­((di­(ethylene glycol) monomethyl ether methacrylate)-ran-(
Lukasz Otulakowski (1391359), Roza Szweda (2890493), Dawid Szweda (1976875), Dominik Kosowski (2890487), Justyna Hertlein (2890490), Andrzej Dworak (1514107), Emi Haladjova (2227018), Stanislav Rangelov (2227015), Barbara Trzebicka (1514089)   +8 more
core   +1 more source

Avian opioid peptides: evolutionary considerations, functional roles and a challenge to address critical questions

Frontiers in Physiology, 2023
The present review considers the putative hormonal opioid peptides in birds. In birds and all other vertebrates, there are four opioid related genes encoding a series of peptides.
Krystyna Pierzchała-Koziec, Colin G. Scanes   +1 more
doaj   +1 more source

Immunocytochemical and ultrastructural differentiation between Met- enkephalin-, Leu-enkephalin-, and Met/Leu-enkephalin-immunoreactive neurons of feline gut

, 1982
Selective immunocytochemical procedures, applied at the light and electron microscopical level, have resulted in the identification of three types of enkephalin-immunoreactive nerves in the feline gastrointestinal tract, including neurons containing ...
K Stengaard-Pendersen, LI Larsson
core   +1 more source

Involvement of the Opioid Peptide Family in Cancer Progression

Biomedicines, 2023
Peptides mediate cancer progression favoring the mitogenesis, migration, and invasion of tumor cells, promoting metastasis and anti-apoptotic mechanisms, and facilitating angiogenesis/lymphangiogenesis.
Manuel Lisardo Sánchez, Francisco D. Rodríguez, Rafael Coveñas   +2 more
doaj   +1 more source

Enkephalin in bovine adrenal gland: Multiple molecular forms of [met5]-enkephalin immunoreactive peptides

, 1980
The existence and heterogeneity of enkephalin-like substances in bovine adrenal glands has been demonstrated using enkephalin radioimmunoassays. Both [met5]- and [leu5]-enkephalins were found to be highly enriched in the medulla i.e.
E. Costa, A. M. Di Giulio, W. Fratta, H. Yang, J. Hong, E. A. Majane   +5 more
core   +1 more source

Delta Opioid Receptor Signaling Promotes Resilience to Stress Under the Repeated Social Defeat Paradigm in Mice

Frontiers in Molecular Neuroscience, 2018
The adaptation to chronic stress is highly variable across individuals. Resilience to stress is a complex process recruiting various brain regions and neurotransmitter systems. The aim of this study was to investigate the involvement of endogenous opioid
Mathilde S. Henry, Kanchan Bisht, Nathalie Vernoux, Louis Gendron, Louis Gendron, Louis Gendron, Angélica Torres-Berrio, Guy Drolet, Guy Drolet, Marie-Ève Tremblay, Marie-Ève Tremblay   +10 more
doaj   +1 more source

Alterations in Cortical and Basal Ganglia Levels of Opioid Receptor Binding in a Rat Model of l-DOPA-Induced Dyskinesia

Neurobiology of Disease, 2001
Opioid receptor-binding autoradiography was used as a way to map sites of altered opioid transmission in a rat model of l-DOPA-induced dyskinesia. Rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathways sustained a 3-week treatment ...
P.A. Johansson, M. Andersson, K.E. Andersson, M.A. Cenci   +3 more
doaj   +1 more source

Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons

eLife, 2021
Functional interactions between G protein-coupled receptors are poised to enhance neuronal sensitivity to neuromodulators and therapeutic drugs. Mu and delta opioid receptors (MORs and DORs) can interact when overexpressed in the same cells, but whether ...
Xinyi Jenny He, Janki Patel, Connor E Weiss, Xiang Ma, Brenda L Bloodgood, Matthew R Banghart   +5 more
doaj   +1 more source