An Effective and Safe Enkephalin Analog for Antinociception
Pharmaceutics, 2021 Opioids account for 69,000 overdose deaths per annum worldwide and cause serious side effects. Safer analgesics are urgently needed. The endogenous opioid peptide Leu-Enkephalin (Leu-ENK) is ineffective when introduced peripherally due to poor stability ...
K. K. DurgaRao Viswanadham +13 more
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Tyr1‑ψ[(Z)CFCH]-Gly2 Fluorinated Peptidomimetic Improves Distribution and Metabolism Properties of Leu-Enkephalin [PDF]
, 2018 Opioid peptides are key regulators in cellular and intercellular physiological responses, and could be therapeutically useful for modulating several pathological conditions.
Ryan A. Altman (1328814) +6 more
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Enkephalin as a Pivotal Player in Neuroadaptations Related to Psychostimulant Addiction
Frontiers in Psychiatry, 2018 Enkephalin expression is high in mesocorticolimbic areas associated with psychostimulant-induced behavioral and neurobiological effects, and may also modulate local neurotransmission in this circuit network.
Bethania Mongi-Bragato +4 more
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Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model-8 [PDF]
, 2011 Reas. . Diet-induced pancreatitis and application of vehicle as control. . Diet-induced pancreatitis and application of the HSV-β-gal control vector. . Animals given the same diet and application of HSV-ENK.
Yong Ren (86476) +7 more
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Effects of Long-term antipsychotic treatment on enkephalin-immunoreactive neurons in rats perinatally treated with phencyclidine [PDF]
Medicinski Podmladak, 2023 Introduction: Schizophrenia is a chronic mental illness that affects 1% of the world's population. The phencyclidine animal model of schizophrenia is based on the glutamate theory of the development of schizophrenia.
Kompanijec Anja +2 more
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Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model-4 [PDF]
, 2011 Ith alcohol and high-fat diet induced pancreatitis at week 10. Minimal staining is typical of peptides in the absence of axonal transport inhibitors since they are rapidly transported to axonal terminals. .
Yong Ren (86476) +7 more
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Synthetic Analogue of Leu-Enkephalin Prevents Endothelial Dysfunction in vitro
Общая реаниматология, 2018 The purpose of the study was to determine the efficacy of a synthetic leu-enkephalin stabilized analogue to prevent damage of endothelial cells monolayer in vitro caused by serum samples from septic shock patients.Materials and methods.
O. A. Grebenchikov +8 more
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Exposure to exogenous enkephalins disrupts reproductive development in the Eastern lubber grasshopper, Romalea microptera (Insecta: Orthoptera). [PDF]
PLoS ONE, 2012 Enkephalins play a major role in reproductive physiology in crustaceans; however their role in reproductive development in insects is largely unknown. We investigated the effect of exposure to exogenous leucine-enkephalin (Leu-Enk), methionine-enkephalin
Sandeep Kumar +4 more
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Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model-1 [PDF]
, 2011 Ncreatitis. Hot plate test was conducted at baseline before induction of pancreatitis and for ten weeks subsequently. Note the significant shortening of hot plate response latencies for rats on the high fat and alcohol diet after week 3, indicating ...
Yong Ren (86476) +7 more
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Immunocytochemical and ultrastructural differentiation between Met- enkephalin-, Leu-enkephalin-, and Met/Leu-enkephalin-immunoreactive neurons of feline gut [PDF]
, 1982 Selective immunocytochemical procedures, applied at the light and electron microscopical level, have resulted in the identification of three types of enkephalin-immunoreactive nerves in the feline gastrointestinal tract, including neurons containing ...
K Stengaard-Pendersen, LI Larsson
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