Results 61 to 70 of about 46,429 (222)

Lyotropy as a Design Consideration for Ultra‐Small Protein Nanoparticles via Electrohydrodynamic Jetting

Macromolecular Rapid Communications, EarlyView.
Lyotropic Ion‐Specific Effects Drive the Synthesis of Ultra‐Small Protein Nanoparticles via Electrohydrodynamic Jetting. ABSTRACT Protein‐based nanoparticles offer tailored bioactivity and biodegradability that are distinct from their synthetic polymeric counterparts.
Muhammad Haseeb Iqbal, Julio Zelaya, Quy Ong, Francesco Stellacci, Joerg Lahann   +4 more
wiley   +1 more source

Comparative Study of Multicanonical and Simulated Annealing Algorithms in the Protein Folding Problem [PDF]

, 1994
We compare a few variants of the recently proposed multicanonical method with the well known simulated annealing for the effectiveness in search of the energy global minimum of a biomolecular system. For this we study in detail Met-enkephalin, one of the
Affinger, Berg, Berg, Berg, Berg, Berg, Berg, Brünger, Brünger, Celik, Chou, Ferrenberg, Ferrenberg, Fukugita, Garrett, Goodsell, Hansmann, Hansmann, Kawai, Kawai, Kirkpatrick, Levitt, Li, Metropolis, Momany, Nakai, Nakazawa, Nilges, Némethy, Okamoto, Okamoto, Okamoto, Okamoto, Okamoto, Shakhnovich, Sipple, Ulrich H.E. Hansmann, von Freyberg, Wilson, Wilson, Wilson, Yuko Okamoto   +41 more
core   +3 more sources

Recent Advancements in the Characterization of D‐Amino Acid and Isoaspartate Post‐Translational Modifications

Mass Spectrometry Reviews, EarlyView.
ABSTRACT One of the great triumphs of mass spectrometry‐based peptide and protein characterization is the characterization of their modifications as most modifications have a characteristic mass shift. What happens when the modification does not change the mass of the peptide?
Samuel Okyem, Jonathan V. Sweedler
wiley   +1 more source

5-HT6R Viral Vector-Mediated Indirect Pathway Activation in the Dorsolateral Striatum: A Discussion on Basal Ganglia Habitual and Goal-Directed Circuits [PDF]

, 2018
Altering maladaptive behavioral tendencies is relevant for clinical interventions, making research on underlying mechanisms of habit essential. Mechanisms of habit are explored here with differential activation of the indirect pathway in the basal ...
Winn, Caleb S
core   +1 more source

Generalized-ensemble Monte carlo method for systems with rough energy landscape

, 1997
We present a novel Monte Carlo algorithm which enhances equilibrization of low-temperature simulations and allows sampling of configurations over a large range of energies.
A. M. Ferrenberg, A. P. Lyubartsev, B. A. Berg, B. A. Berg, B. A. Berg, B. A. Berg, B. Hesselbo, C. Tsallis, D. A. Stariolo, E. Marinari, H. Kawai, I. Andricioaei, M. J. Sippl, M.-H. Hao, R. H. Swendsen, U. H. E. Hansmann, U. H. E. Hansmann, U. H. E. Hansmann, Ulrich H. E. Hansmann, Y. Okamoto, Yuko Okamoto   +20 more
core   +1 more source

Cerebrospinal Fluid Proenkephalin Predicts Striatal Atrophy Decades before Clinical Motor Diagnosis in Huntington's Disease

Movement Disorders, EarlyView.
Abstract Background Huntington's disease (HD) is characterized by early, selective, progressive vulnerability of striatal medium spiny neurons (MSNs). Proenkephalin (PENK), a precursor of opioid peptides abundantly expressed in MSNs, is a promising biomarker of striatal integrity, but region‐specific associations and its potential for early‐stage ...
Mena Farag, Michael J. Murphy, Nicola Z. Hobbs, Michela Leocadi, Kate Fayer, Olivia Thackeray, Johan Gobom, Marc Ciosi, Amanda Heslegrave, Henrik Zetterberg, Douglas R. Langbehn, Darren G. Monckton, Edward J. Wild, Sarah J. Tabrizi, Rachael I. Scahill   +14 more
wiley   +1 more source

N‐Geranylated Amino Acid Surfactants with Low Critical Micelle Concentrations from Abundant, Naturally Derived Starting Materials

ChemistryOpen, EarlyView.
Cleaning Up Surfactants: Realising critical micelle concentrations lower than sodium dodecyl sulfate with sustainable surfactants prepared from amino acids and naturally occurring aldehydes. In this work, a simple method for the preparation of N‐alkylated amino acid surfactants in 1–2 steps is reported.
Brett L. Pollard, Yumeng Liu, Michael G. Gardiner, Luke A. Connal   +3 more
wiley   +1 more source

Spatial relationship between the c-Fos distribution and enkephalinergic, substance P, and tyrosine hydroxylase innervation fields after acute treatment with neuroleptics olanzapine, amisulpride, quetiapine, and aripiprazole in the rat septum

Endocrine Regulations, 2019
Objective. The aim of the present study was to demonstrate the spatial relationship between the c-Fos immunoreactive cells elicited by an acute treatment with neuroleptics including amisulpride (AMI), olanzapine (OLA), quetiapine (QUE), and aripiprazole (
Kiss Alexander, Osacka Jana
doaj   +1 more source

Hepatoprotective Effects of Met-enkephalin on Acetaminophen-Induced Liver Lesions in Male CBA Mice

Molecules, 2014
Recent histopathological investigations in patients with hepatitis suggested possible involvement of Met-enkephalin and its receptors in the pathophysiology of hepatitis.
Roko Martinić, Hrvoje Šošić, Petra Turčić, Paško Konjevoda, Aleksandra Fučić, Ranko Stojković, Gorana Aralica, Mario Gabričević, Tin Weitner, Nikola Štambuk   +9 more
doaj   +1 more source

New Aspects of Thromboangiitis obliterans (von Winiwarter-Buerger's Disease) [PDF]

, 1984
The existence of thromboangiitis obliterans as a clinical entity has been a matter of debate for many years. In contrast to other immunovasculitides there is no organ involvement while peripheral vessels are affected.
Berlit, Peter, Kessler, C., Krause, Klaus-Henning, Reuther, R.   +3 more
core   +1 more source