Results 11 to 20 of about 33,942 (331)

Enkephalins: Endogenous Analgesics with an Emerging Role in Stress Resilience

Neural Plasticity, 2017
Psychological stress is a state of mental or emotional strain or tension that results from adverse or demanding circumstances. Chronic stress is well known to induce anxiety disorders and major depression; it is also considered a risk factor for ...
Mathilde S. Henry, Louis Gendron, Marie-Eve Tremblay, Guy Drolet   +3 more
doaj   +2 more sources

A Novel Ophthalmic Solution Containing Glicopro^® Complex for the Treatment of Patients with Dry Eye Disease: Results from a Pilot Study. [PDF]

J Clin Med
Background: Dry eye disease (DED) is a multifactorial ocular surface disease characterized by an imbalance in ocular surface homeostasis, and tear substitutes constitute the first line of treatment.
Giannaccare G, Vaccaro S, Borselli M, Rossi C, Carnovale Scalzo G, Scalia G, Di Cesare Mannelli L, Ghelardini C, Zerillo L, Polvere I, Vito P, Zotti T, Stilo R, Scorcia V.   +13 more
europepmc   +3 more sources

Role of enkephalin derivative in promoting wound healing and scar remodeling via increased epidermal growth factor in a mouse model [PDF]

Archives of Aesthetic Plastic Surgery, 2023
Background Enkephalin, an endogenous neuropeptide, binds to the delta (δ) opioid receptor and exerts an antinociceptive effect. Recent studies have suggested that neuropeptides might effectuate cutaneous wound healing.
Sun Eung Kim, Yu Jin Kim, Young Woo Cheon   +2 more
doaj   +1 more source

CARDIOPROTECTIVE EFFECT OF ENKEPHALINS UNDER IMMOBILIZATION STRESS [PDF]

Biotechnologia Acta, 2022
Objective: The aim of this study was to investigate the cardioprotective effect of dalargin, a synthetic leu-enkephalin. Methods: The induction of myocardial infarction in rats, which were kept on a diet with excess fat and calcium/sodium salts for ...
І. J. Shcheniavskyi
doaj   +1 more source

AAV gene therapy vectors in the TMJ

Clinical and Experimental Dental Research, Volume 8, Issue 6, Page 1561-1566, December 2022., 2022
Abstract Objectives The goal of this project was to evaluate the use of two adeno‐associated viral vector serotypes, adeno‐associated viral vectors (AAV)‐2 and AAV‐6, approved for and used for gene therapy in humans, for the delivery of therapeutic genes to the temporomandibular joint (TMJ) and the attendant sensory nerves.
Sabine M. Brouxhon, Michael Kerry O'Banion, Stephanos Kyrkanides   +2 more
wiley   +1 more source

Co-Expression of Tardive Dyskinesia and Drug-Induced Parkinsonism in Rats Chronically Treated With Haloperidol. [PDF]

Neuropsychopharmacol Rep
Rats chronically treated with haloperidol exhibit drug‐induced parkinsonism and tardive dyskinesia. Expression of dynorphin, enkephalin, and dopamine D1 and D2 receptors was altered in haloperidol‐treated rats. Both indirect and direct pathways are involved in haloperidol‐induced movement disorders.
Kinoshita I, Nishijima H, Nakamura T, Kon T, Shimoyama S, Hikichi H, Suzuki C, Tomiyama M.   +7 more
europepmc   +2 more sources

Ultra‐high‐performance supercritical fluid chromatography‐mass spectrometry for the analysis of organic contaminants in sediments

Journal of Separation Science, Volume 46, Issue 1, January 2023., 2023
A nontarget screening method was developed based on D‐optimal designs for ultra‐high performance supercritical fluid chromatography with positive and negative electrospray ionization mode mass spectrometry. A mixture of organic contaminants such as pesticides, steroids, surfactants, phenolic and fatty acids, and polycyclic aromatic hydrocarbon ...
Josephine S. Lübeck, Jan H. Christensen, Giorgio Tomasi   +2 more
wiley   +1 more source

A “Drug-Dependent” Immune System Can Compromise Protection against Infection: The Relationships between Psychostimulants and HIV

Viruses, 2021
Psychostimulant use is a major comorbidity in people living with HIV, which was initially explained by them adopting risky behaviors that facilitate HIV transmission.
María Amparo Assis, Pedro Gabriel Carranza, Emilio Ambrosio   +2 more
doaj   +1 more source

New perspectives in the pathophysiology and treatment of pain in patients with dry eye disease [PDF]

, 2022
Ocular discomfort and eye pain are frequently reported by patients with dry eye disease (DED), and their management remains a real therapeutic challenge for the Ophthalmologist. In DED patients, injury at the level of each structure of the ocular surface
Ghelardini C., Giannaccare G., Mancini A., Mannelli L. D. C., Scorcia V.   +4 more
core   +1 more source

Alkannin exerts antitumor properties in cutaneous squamous cell carcinoma by inducing apoptosis and shifting the M1/M2 polarization of tumor‐associated macrophages by upregulating PTEN

The Kaohsiung Journal of Medical Sciences, Volume 39, Issue 1, Page 70-79, January 2023., 2023
Abstract Cutaneous squamous cell carcinoma (CSCC) is a common cancer in humans and is the second major type of skin cancer that causes death in humans. In this article, we investigated the effects of alkannin on CSCC progression. We revealed that alkannin curbed CSCC cell viability in a dose‐dependent manner and accelerated CSCC cell apoptosis.
Zhong‐Zhao Zhang, Chang‐Hui Wen, Min Jia, Hong‐Qiang Zhang, Shao‐Qin Sun   +4 more
wiley   +1 more source