Results 51 to 60 of about 33,942 (331)
Structure of the Energy Landscape of Short Peptides [PDF]
Int. J. of Mod. Phys. C 14(1), xxx (2003), 2002 We have simulated, as a showcase, the pentapeptide Met-enkephalin (Tyr-Gly-Gly-Phe-Met) to visualize the energy landscape and investigate the conformational coverage by the multicanonical method. We have obtained a three-dimensional topographic picture of the whole energy landscape by plotting the histogram with respect to energy(temperature) and the ...
arxiv +1 more source
Substantia, 2018 Opium was known since the Neolithic era and in 5th century wild Papaver use was reported to induce sleep and relieving pain. First active component isolated from Opium was morphine, the paradigm of a natural product discovered 150 years before isolation ...
Anna Maria Papini
doaj +1 more source
Selank effects on morphine-induced analgesia in vivo experiments
Фармакокинетика и Фармакодинамика, 2022 Background. The endogenous opioid system is involved in neuroadaptation produced by exogenous opioids. Synthesized on the basis of the regulatory peptide tuftsin, the anxiolytic selank inhibits the activity of enkephalin-degrading enzymes, increasing the
A. V. Nadorova +2 more
doaj +1 more source
Parallel Tempering Algorithm for Conformational Studies of Biological Molecules [PDF]
Chem.~Phys.~Lett. 281 (1997) 140-150, 1997 The effectiveness of a new algorithm, parallel tempering, is studied for numerical simulations of biological molecules. These molecules suffer from a rough energy landscape. The resulting slowing down in numerical simulations is overcome by the new method.
arxiv +1 more source
Geroprotective properties of neuroprotective and neurotrophic peptides
Неврология, нейропсихиатрия, психосоматика, 2020 Objective: to elucidate whether cerebrolysin contains peptide fragments that promote geroprotection.Material and methods. The peptide composition of cerebrolysin underwent a comprehensive mass spectrometric analysis, followed by a systemic biological ...
O. A. Gromova +4 more
doaj +1 more source
Effective Sampling in the Configurational Space by the Multicanonical-Multioverlap Algorithm [PDF]
, 2006 We propose a new generalized-ensemble algorithm, which we refer to as the multicanonical-multioverlap algorithm. By utilizing a non-Boltzmann weight factor, this method realizes a random walk in the multi-dimensional, energy-overlap space and explores widely in the configurational space including specific configurations, where the overlap of a ...
arxiv +1 more source
Opioid-like peptides and ghrelin mitigation of bariatric results depends on obesity level [PDF]
, 2020 Introduction: Bariatric surgery, as the only effective treatment of obesity, has strong effects on the metabolism, and nervous and endocrine systems. Thus, based on the different opinions about the efficaciousness of morbid obesity treatments, the aim of
Cieśla, Andrzej +6 more
core +2 more sources
Journal of Biological Chemistry, 1983 Enkephalin convertase, an enkephalin-synthesizing carboxypeptidase present in adrenal medulla chromaffin granules, has also been detected in brain and pituitary. To determine whether these three carboxypeptidase activities represent the same enzyme, we purified and characterized enkephalin convertase from adrenal medulla, whole brain, and whole ...
Lloyd D. Fricker, Solomon H. Snyder
openaire +3 more sources
RELEASE OF VASOPRESSIN BY ENKEPHALIN [PDF]
British Journal of Pharmacology, 1978 Leu‐enkephalin, its stable analogue [D‐Ala2‐D‐Leu5]‐enkephalin and the C‐fragment of lipotropin (β endorphin) injected intravenously in the rat produced anti‐diuretic responses which were inhibited reversibly by naloxone. It was shown for Leu‐enkephalin that injection into the cerebral ventricles was at least ten times more effective than intravenous ...
W. Feldberg, G. W. Bisset, H.S. Chowdrey
openaire +3 more sources
The Journal of comparative neurology, 2009 To characterize neuronal pathways that release opioid peptides in the rat dorsal horn, multiple‐label immunohistochemistry, confocal microscopy, and computerized co‐localization measures were used to characterize opioid‐containing terminals and cells. An
J. Marvizón, Wenling Chen, N. Murphy
semanticscholar +1 more source